3119-02-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3119-02-6, name is 4-Cyanobenzenesulphonamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 4-cyano benzenesulfonamide (3.8 g, 20.88 mmol, Intermediate 42 or commercial source: Combi-Blocks) in Lambda/,/V-dimethylformamide (50 mL), sodium azide (13.57 g, 208.73 mmol) and ammonium chloride (1 1.17 g, 208.78 mmol) were added at 27 C. The reaction mixture was heated to 120 C and was stirred at the same temperature for 5 h. Upon completion, the reaction mixture was cooled to 27 C, quenched with 1 N HCI (150 mL) and extracted with ethyl acetate (3×100 mL). The organic layer was dried over anhydrous Na2S04, filtered and the filtrate was concentrated under reduced pressure. The residue was stirred with dichloromethane (10 mL) at 27 C for 30 min and filtered. The solid was dried under vacuum to afford 4-(2H-tetrazol-5- yl)benzenesulfonamide (3.2 g, 68%) as an off-white solid.1H NMR (400 MHz, DMSO-c/6) delta 8.23 (d, J = 8.5 Hz, 2H), 8.04 (d, J = 8.5 Hz, 2H), 7.53 (s, 2H). MS m/z [M-H]”=224.03.
The synthetic route of 4-Cyanobenzenesulphonamide has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ALEMPARTE-GALLARDO, Carlos; ENCINAS, Lourdes; ESQUIVIAS PROVENCIO, Jorge; (206 pag.)WO2019/34729; (2019); A1;,
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