Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 621-38-5, name is 3-Bromoacetanilide, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 3-Bromoacetanilide
0.05 g of tetrakistriphenylphosphine palladium was added at room temperature to a solution having 0.21 g of 3-bromo-acetoanilide obtained by (1) dissolved in 5 ml of toluene, followed by stirring for 15 minutes. 0.25 g of 2,4, 6-trimethylphenyl boronic acid,. 2 ml of ethanol and 3 ml of a 2M sodium carbonate solution were sequentially added thereto, and the reaction system was flushed with nitrogen, followed by stirring for 12 hours under reflux under heating. After cooling, 10 ml of cold water was added, followed by extraction with 15 ml and 10 ml of ethyl acetate. The organic layers were put together and dried over anhydrous sodium sulfate, and then the solvent was distilled off under reduced pressure. The residue was purified by silica gel (Silica gel 60N; spherical and neutral, manufactured by Kanto Kagaku) column chromatography (developing solvent of n-hexane: ethyl acetate=2: 1) to obtain 0.15 g of the objective compound having a melting point of 173. 8C. Further, NMR of this compound was as follows. H-NMR 5 (ppm) 1. 98 (s, 6H), 2.15 (s, 3H), 2. 30 (s, 3H), 6. 85 (d, lH ; J =8. 0 Hz), 6. 90 (s, 2H), 7.16 (s, lH), 7. 33 (t, lH; J =8. 0 Hz), 7.41 (bs, lH), 7.57 (d, lH; J =8.0 Hz)
According to the analysis of related databases, 621-38-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ISHIHARA SANGYO KAISHA, LTD.?; WO2005/44007; (2005); A1;,
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