A new synthetic route of 154350-29-5

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Cyclopropanesulfonamide, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 154350-29-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 154350-29-5, name is Cyclopropanesulfonamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a toluene 85ml solution of (1R, 5S, 6r)-tert- butyl 6- (3-bromophenyl) -6-ethyl-3-azabicyclo [3.1.0] hexane-3-carboxylate8.54g (23.3mmol) obtained in Reference Example 1- (b), under an argonatmosphere, with stirring at room temperature, cyclopropanesulfonamide3.67g (30.3mmol), potassium carbonate 4.51g (32.6mmol), bis (eta3- allyl -mu-chloro palladium) 0.170g (0.465mmol) and tert- butyl XPhos0.600g (1.41mmol)were added, and the mixture was stirred for 1 hour at 110 .After completion of the reaction, water was added to the reaction mixture, andthe mixture was extracted with toluene. The organic layer was dried over anhydrous magnesium sulfate, andconcentrated under reduced pressure. The residue was subjected to silica gelcolumn chromatography (eluent hexane: ethyl acetate = 80: 20 ? 70: 30 (V / V)),and the fractions containing the desired product were concentrated underreduced pressure, and the precipitated solid was sonicated with a solution ofhexane: acetic acid ethyl = 1: 1 (V / V) and stirred, and by filtration, thetitle compound 7.86g as a white solid (83percent yield) was obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Cyclopropanesulfonamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SANWA KAGAKU KENKYUSHO COMPANY LIMITED; UBE INDUSTRIES,LIMITED; TANIKO, KAORI; MIYAZAWA, TOSHIYUKI; KANEKO, TATSUROH; KURUMAZUKA, DAISUKE; HARADA, SATOKO; IZUCHI, TOHRU; OKABE, MORIO; IWAMURA, RYO; TSUZAKI, YASUNORI; SETOGUCHI, HIROYUKI; IMURA, YUUKI; AKAZA, HIROTO; SHIMIZU, MOTOHISA; KIMURA, TOMIO; (73 pag.)JP5860192; (2016); B2;,
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