In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (2-aminophenyl)carbamate, other downstream synthetic routes, hurry up and to see.
Reference of 146651-75-4, The chemical industry reduces the impact on the environment during synthesis 146651-75-4, name is tert-Butyl (2-aminophenyl)carbamate, I believe this compound will play a more active role in future production and life.
Example 6; Ethyl l-methyl-8-(2-(^-butoxycarbonylaminophenylamino)-4,5-dihydro-lH- pyrazolo[4,3-h]quinazoline-3-carboxylate (A12BlC2Z); Palladium acetate [Pd(OAc)2] (101 mg, 0.45 mmol), (+)-BINAP (280 mg, 0.45 mmol) and dimethylformamide (65 niL) were charged to a round-bottom flask flushed with argon. The flask was evacuated and backfilled with argon. The mixture was stirred under argon for 30 minutes and added to a mixture of 2-(t- butoxycarbonylamino)aniline (2.6 g, 12.5 mmol), ethyl 8-iodo-l-methyl-4,5-dihydro- lH-pyrazolo[4,3-h]quinazoline-3-carboxylate (1.6 g, 4.16 mmol), and potassium carbonate (5.74 g, 41.6 mmol) in dimethylformamide (50 mL). The resulting mixture was stirred at 700C for 6 hours under argon. After cooling to room temperature, the reaction mixture was filtered on a pad of celite. The solvent was concentrated, the crude solid was purified by flash chromatography on silica gel (eluant: hexane/ethyl acetate 60/40) to afford 1.18 g (61% yield) of the title compound. 1H NMR (400 MHz, DMSO- d6) delta ppm 1.32 (t, J=I lambda Hz, 3 H) 1.46 (s, 9 H) 2.84 (m, 4 H) 2.96 (m, 2 H) 4.20 (s, 3 H) 4.30 (q, J= 7.1 Hz, 2 H) 7.12 (m, 2 H) 7.51 (m, 1 H) 7.71 (m, 1 H) 8.38 (s, 1 H) 8.65 (s, 1 H) 8.60 (s, 1 H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (2-aminophenyl)carbamate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NERVIANO MEDICAL SCIENCES S.r.l.; WO2008/74788; (2008); A1;,
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