Application of 14658-93-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14658-93-6 as follows.
General procedure: A solution of 0.04 g (0.11 mmol) of methyl 2-Z-(C-(bromomethyl)-N-tetrahydropyran-2-yloxy-carbonimidoyl)pyridine-4-carboxylate (Intermediate 12) in 0.5 mL of dry THE was added drop wise at 0C and under nitrogen atmosphere to a suspension of 0.024 g (0.13 mmol) of tert-butyl N-(2-hydroxyethyl)-N-methyl-carbamate and 0.0054 g (0.13 mmol) of NaH (60% mineral oil) in 0.5 mL of dry THE. Once the addition was complete, the reaction mixture was quenched with 5% citric acid and extracted with DCM and DCM/MeOH90:10. The combined organic layers were dried, concentrated and the crude product was purified by flash chromatography (eluent DCM:MeOH 97:3) to afford 0.022 g (27%) of 2- [(Z)-C-[2-(tert-butoxycarbonyl (methyl )am ino)ethoxymethyl]-N-tetrahydropyran-2-yloxy- carbonimidoyl]pyridine-4-carboxylic acid (Intermediate 19). MS (ESI): mlz: 436 [M-H].
According to the analysis of related databases, 14658-93-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; IEO – ISTITUTO EUROPEO DI ONCOLOGIA S.R.L.; VARASI, Mario; VILLA, Manuela; TRIFIRO’, Paolo; FANCELLI, Daniele; MERCURIO, Ciro; VIANELLO, Paola; SARTORI, Luca; (202 pag.)WO2017/198785; (2017); A1;,
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