Related Products of 72080-83-2, A common heterocyclic compound, 72080-83-2, name is Benzyl (2-aminoethyl)carbamate, molecular formula is C10H14N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1-((Dimethylamino)(dimethyliminio)methyl)-1H-[1,2,3]triazolo[4,5-b]pyridine 3-oxide hexafluorophosphate(V) (HATU, 1.87 g, 4.92 mmol) and triethylamine (3.43 mL, 24.6 mmol) were subsequently added to a solution of (S)-22-(tert-butoxycarbonyl)-10,19,24-trioxo-39-sulfo-3,6,12,15-tetraoxa-9,18,23-triazanonatriacontanoic acid (4.5 mmol) in dry dichloromethane (40 mL). Triethylamine (1.82 mL, 13.1 mmol) was added to a suspension of (2-amino-ethyl)-carbamic acid benzyl ester hydrochloride (5, 1.93 g, 8.37 mmol) in dry dichloromethane (20 mL) and the resulting mixture was added to the above solution. The mixture was stirred overnight at room temperature. After 16 hours, another portion of 1-((dimethylamino)(dimethyliminio)methyl)-1H-[1,2,3]triazolo[4,5-b]pyridine 3-oxide hexafluorophosphate(V) (HATU, 0.38 g, 1 mmol), triethylamine (2.00 mL, 14.3 mmol) and (2-amino-ethyl)-carbamic acid benzyl ester hydrochloride (5, 0.40 g, 1.70 mmol) were added and the mixture was stirred for another 2 hours. The solution was washed with 1 M aqueous hydrochloric acid (2¡Á100 mL) and brine (50 mL), dried over anhydrous sodium sulfate and evaporated to dryness. Crude (S)-29-(tert-butoxycarbonyl)-3,8,17,26,31-pentaoxo-1-phenyl-2,10,13,19,22-pentaoxa-4,7,16,25,30-pentaazahexatetracontane-46-sulfonic acid (6) was used for the next step without further purification. (0579) Yield: quantitative (based on ELSD). (0580) LC-MS purity: 83% (ELSD). (0581) LC-MS Rt (Kinetex C18, 4.6 mm¡Á50 mm, acetonitrile/water 20:80 to 100:0+0.1% FA): 3.35 min. (0582) LC-MS m/z: 989.1 (M+H)+.
The synthetic route of 72080-83-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Novo Nordisk A/S; Gao, Xiang; Zhang, Xujia; Guan, Hongtao; Thoegersen, Henning; Sass-Oerum, Kristian; Iversen, Lars Fogh; Noergaard, Per; Joergensen, Sebastian Beck; Hansen, Kristian Tage; Wang, Yi; Frieboes, Kilian Waldemar Conde; Wieczorek, Birgit; (259 pag.)US2018/339057; (2018); A1;,
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