Application of 4815-28-5,Some common heterocyclic compound, 4815-28-5, name is 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, molecular formula is C9H12N2OS, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A solution of 2-aminothiophene derivatives 1a-c (0.01 mol) in 7.2 mL conc. HCl and 4 mL H2O was stirred and cooled in ice bath. Then, a solution of NaNO2 (0.690 g,0.01 mol) in 8 mL H2O was added dropwise for 10 min. The cold diazonium solution was added slowly to awell-stirred solution of 3-iminobutanenitrile (0.82 g, 0.01mol) or 1-phenyl-2-thiocyanatoethanone (1.78 g, 0.01mol), in ethanol (60 mL) containing sodium acetate (4 g, 0.05 mol). The reaction mixture was stirred for another3 h. The formed precipitate was filtered off, dried well, and recrystallized from ethanol/benzene to give 3a-c and 7
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, its application will become more common.
Reference:
Article; Gouda, Moustafa A.; Eldien, Hadeer Fakhr; Girges, Margret M.; Berghot, Moged A.; Indian Journal of Heterocyclic Chemistry; vol. 28; 3; (2018); p. 401 – 405;,
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