These common heterocyclic compound, 4815-28-5, name is 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
To a stirred solution of the appropriate aminothiophene (1 equiv. ) in 1,4-dioxane (5ml per mmol of aminothiophene) was added the appropriate acyl chloride (1.2 equiv. ). The reaction mixture was stirred at room temperature for 17 hours and then diluted with ether or hexane. The resultant precipitate was removed by filtration, washed with ether and air- dried to give the desired product. Compound No. 390 of Table 14 Using the additional general procedure 2- (2-chloroacetylamino)-4, 5,6, 7-tetrahydro- benzo [b] thiophene-3-carboxylic acid amide (Compound No. 390 of Table 14) was obtained from aminothiophene WO as an off-white solid in 52% yield. m. p. 242-245C (dec.).
The synthetic route of 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; SYNGENTA LIMITED; WO2005/44008; (2005); A2;,
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