In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 683-57-8, name is 2-Bromoacetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 683-57-8
INTERMEDIATE 226: methyl 3-(2-amino-2-oxoethoxy)-5-(5-((((R)-2-((R)-1-(N- (benzyloxy)formamido) propyl)heptanamido)methyl)carbamoyl)furan-2-yl)benzoate A mixture of methyl 3-(5-((((R)-2-((R)-1-(N- (benzyloxy)formamido) propyl) heptanamido) methyl)carbamoyl)furan-2-yl)-5-hydroxybenzoate (0.25 g, 0.42 mmol), 2-bromoacetamide (0.116 g, 0.842 mmol), and K2003 (0.29 g, 2.106 mmol) in acetonitrile (1.50 ml) was heated at 8000 for 1 hour. The reaction was then cooled to RT and concentrated in-vacuo. The residue was partitionedbetween H20 and EtOAc and the organic layer was separated. The organic layer was washed with brine, dried over MgSO4, filtered, and concentrated under vacuum to afford a white solid. The solid was purified by flash column chromotography (20- 100%EtOAc:Hexane) to afford the titled compound.(0.22 g, 80 % yield) as white solid. MS (mlz) 651.2 (M+H+).
The synthetic route of 683-57-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; DOWDELL, Sarah E.; EIDAM, Hilary Schenck; ELBAN, Mark; FOX, Ryan Michael; HAMMOND, Marlys; HILFIKER, Mark A.; HOANG, Tram H.; KALLANDER, Lara S.; LAWHORN, Brian Griffin; MANNS, Sharada; PHILP, Joanne; WASHBURN, David G.; YE, Guosen; WO2015/104684; (2015); A1;,
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