Related Products of 180079-94-1,Some common heterocyclic compound, 180079-94-1, name is tert-Butyl 3-aminophenethylcarbamate, molecular formula is C13H20N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Synthesis of TU71 N-Boc 3-(2′-amino)ethyl aniline (200 mg, 0.8 mmol), DCM (3 mL) and triethyl amine (0.15 mL) in a round bottom flask that had been flame dried in the presence of molecular sieves and cooled under vacuum was stirred at 4 C. After 10 min di 2-pyridyl thionocarbonate (200 mg, 0.8 mmol) was added. The reaction was stirred overnight at 4 C after which time the DCM layer was washed twice with water and once with brine. Chromatography on silica gel yielded the titled compound (0.1 g, 59 %) as a white solid. deltaEta (400 mHz, CDC13) 1.405 (9H, s), 2.753 (2H, t, J=6.8 Hz), 3.327 (2H, q, J=6.8 Hz), 4.611 (1H, br s), 7.036- 7.089 (3H, m), 7.228-7.266 (2H, m). 5C (100 mHz, CDC13) 28.65, 35.228, 41.301, 77.954, 133.806, 126.711, 129.006, 130.129, 133.727, 142.175, 155.936. m/z 279 (MH+). HREIMS found 279.1170 C14H19N202S, requires 279.1167.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl 3-aminophenethylcarbamate, its application will become more common.
Reference:
Patent; BRANDEIS UNIVERSITY; HEDSTROM, Lizbeth, K.; LONG, Marcus, J.; LAWSON, Ann, Parrinello; (70 pag.)WO2016/14522; (2016); A1;,
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