108-13-4, name is Malonamide, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C3H6N2O2
To a solution of malonic-acid diamide (1 g) in DMF (15 mL), N,N dimethylformamide-dimethylacetal (1.4 g) added slowly. Then the mixture heated up to 50 C. and stirred for 3 h. The product isolated after concentration the mixture followed by crystallization (410 mg).1H NMR. (DMSO d6) delta: 7.45 and 7.02 (each bs, 4H, 2¡Á-NH2), 7.40 (s, 1H, -CH), 2.94 and 2.89 (2¡Ás, each 3H, 2¡Á-NCH3).13C NMR (DMSO d6) delta: 169.16 and 169.15 (2¡ÁCO), 151.08 (-HN-CH), 96.37 (C qvat.), 43.07 and 42.95 (2¡ÁNCH3).
The synthetic route of 108-13-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dekany, Gyula; Agoston, Karoly; Bajza, Istvan; B¡ãjstrup, Marie; Kroeger, Lars; US2009/234111; (2009); A1;,
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