Application of 72505-21-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72505-21-6 name is 4-(Trifluoromethyl)thiobenzamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: A solution of 3-bromo-1-benzofuran-2(3H)-one (0.5 g,2.35 mmol) in toluene (5 mL) was added dropwise to a suspensionof the corresponding thioamide (2.35 mmol) and pyridine (65 mL,0.8 mmol) in toluene (5 mL) at room temperature. The reactionmixturewas stirred and heated at 80C for 2 h and then cooled. The amorphous precipitate was collected by filtration and thenrecrystallized from 80% aqueous ethanol to give products 1a-h as orange crystals. Alternative method for synthesis of 1a is alsodescribed in Ref. [25].
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(Trifluoromethyl)thiobenzamide, and friends who are interested can also refer to it.
Reference:
Article; Kammel, Richard; Tarabova, Denisa; Machalicky, Old?ich; Nepra?, Milo?; Frumarova, Bo?ena; Hanusek, Ji?i; Dyes and Pigments; vol. 128; (2016); p. 101 – 110;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics