Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 138-41-0, name is Carzenide, A new synthetic method of this compound is introduced below., Recommanded Product: 138-41-0
General procedure: To a solution of the carboxylic acids 33-36 (0.45 mmol) indimethylformamide (3 mL), an excess of EDCI (0.54 mmol) andhydroxybenzotriazole monohydrate (0.54 mmol), and a catalytic amount ofdimethylaminopyridine (0.02 mmol) were added. The mixture was stirred at roomtemperature for 2 h, then 5-(4-(aminomethyl)piperidin-1-yl)-2-(furan-2-yl)thiazolo[5,4-d]pyrimidin-7-amine(32) (0.49 mmol) was added. After stirring at room temperature for 3 h,20 mL of H2O were added to precipitate a solid which was filtered,washed with water and purified by column chromatography. N-((1-(7-Amino-2-(furan-2-yl)thiazolo[5,4-d]pyrimidin-5-yl)piperidin-4-yl)methyl)-4-sulfamoylbenzamide(8) Yield 85%. Mp: 166-168 C (column chromatography, eluting system ethylacetate/cyclohexane/methanol 7/2/1). 1H NMR (DMSO-d6): delta 8.71(t, 1H, NHCO, J=5.3 Hz), 8.00(d, 2H, J=8.4 Hz), 7.93-7.83(m, 3H), 7.48 (s, 2H, NH2), 7.24 (s, 2H, NH2), 7.05 (d,1H, J=3.2 Hz), 6.73-6.72 (m,1H), 4.68 (d, 2H, J=12.7 Hz),3.21-3.18 (m, 2H), 2.83 (t, 2H, J=12.0Hz), 1.86 (br s, 1H), 1.75 (d, 2H, J=11.8Hz), 1.14-1.11 (m, 2H). 13C NMR (DMSO-d6): delta 165.82,165.14, 159.21, 157.23, 148.62, 146.61, 145.80, 138.01, 128.34, 126.06, 124.69,113.20, 110.08, 45.35, 44.18, 36.55, 30.08. Anal. calcd. for (C22H23N7O4S2):C, 51.45%; H, 4.51%; N, 19.09%. Anal. found: C, 51.76%; H, 4.85%; N, 19.33%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Catarzi, Daniela; Colotta, Vittoria; Espindola Gelsleichter, Nicolly; Guilbaud, Audrey; Lopes Rangel Fietto, Juliana; Pasquini, Silvia; Pelletier, Julie; Sevigny, Jean; Sarlandie, Marine; Varani, Katia; Varano, Flavia; Vincenzi, Fabrizio; Bioorganic and medicinal chemistry letters; (2020);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics