Synthetic Route of 154350-29-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 154350-29-5, name is Cyclopropanesulfonamide, This compound has unique chemical properties. The synthetic route is as follows.
Stage lc:oI IBocHN-SI Io[0182] Cyclopropanesulfonamide (5.0 g, 41.26 mmol, 1.0 eq.), triethylamine (8.62 g, 61.90 mmol, 1.5 eq.) and dichloromethane (50 mL) were charged in a 100 mL round bottom flask. Di-te/t-butyldicarbonate (10.8 g, 49.52 mmol, 1.2 eq.) and N,N- dimethylaminopyridine (252 mg, 2.06 mmol, 0.05 eq.) were added portion wise and the reaction mixture stirred at ambient temperature for 48 hours. The solvent was removed in vacuo and the residue diluted with water (20 mL). The aqueous phase was acidified to pH = 1 with 1M hydrochloric acid, and extracted with ethyl acetate (3 x 100 mL). The organic extracts were combined, washed with water (100 mL) and brine (100 mL), dried over magnesium sulfate, filtered and the solvent removed in vacuo to give 9.1 g (99percent yield) of the title compound as a white solid. 1H NMR (500 MHz, CDC13) delta ppm 7.14 (br. s., 1 H) 2.90 (tt, 7=8.09, 4.73 Hz, 1 H) 1.50 – 1.54 (m, 9 H) 1.35 – 1.40 (m, 2 H) 1.09 – 1.15 (m, 2 H). LC-MS: purity 100percent (UV), tR 1.62 min m/z [M+Na]+ 243.95 (MET/CR/1278).
The chemical industry reduces the impact on the environment during synthesis Cyclopropanesulfonamide. I believe this compound will play a more active role in future production and life.
Reference:
Patent; INTERMUNE, INC.; BUCKMAN, Brad; NICHOLAS, John, B.; SEREBRYANY, Vladimir; SEIWERT, Scott, D.; WO2012/37259; (2012); A1;,
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