Extended knowledge of 6292-59-7

Electric Literature of 6292-59-7, These common heterocyclic compound, 6292-59-7, name is 4-(tert-Butyl)benzenesulfonamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 5-(2-methoxyphenoxy)-2-(2′-pyrimidinyl)-4,6-dihydroxy pyrimidine compound of formula-4 (100 g), POCI3 (500 ml) was added. Heated the reaction mixture to 90¡ãC and stirred for 30 min. The temperature of the reaction mixture was raised to 105¡ãC and was stirred for 8 hrs. The reaction mixture was cooled to 6O0C and concentrated to obtain a residue. The reaction mixture was quenched with ice water and toluene (1200 ml) was added to it. The pH was adjusted to 8-9 with 30percent sodium hydroxide solution. The organic and the aqueous layers were separated. The aqueous layer was extracted with toluene (200 ml). The organic layers were combined, washed with water and dried. The solvent was concentrated to 1200 ml and a solution of 4-tert- butyl benzene sulfonamide (6) (48 g) in toluene (600 ml), potassium carbonate (35 g) and tetra butyl ammonium bromide (10 g) was added and the reaction mixture was heated to 50¡ãC. The reaction mixture was heated to refluxed using dean stark apparatus for 10 hrs. The reaction mixture was cooled to 25¡ãC.The solid obtained was filtered and made slurry in water. The solid was filtered, washed with water and dried. Yield: 92 g

Statistics shows that 4-(tert-Butyl)benzenesulfonamide is playing an increasingly important role. we look forward to future research findings about 6292-59-7.

Reference:
Patent; MSN LABORATORIES LIMITED; WO2009/95933; (2009); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics