In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 758-96-3 as follows. Computed Properties of C5H11NO
Weigh benzothiazole (0.5mmol, 67mg), K2S2O8 (2mmol, 0.54g) and Eosin Y (0.01mmol, 6.5mg) in a 25mL Schlenk reaction tube, and then add N, N-dimethylpropionamide (38mmol, 3.8g), placed under a 20W LED white light to react, stirred the reaction at room temperature, followed by TLC to monitor the progress of the reaction, the reaction was completed after 24 hours, the reaction solution was concentrated to remove the solvent, and the concentrated solution was separated by column chromatography (eluent Petroleum ether / ethyl acetate) in a volume ratio of 5: 1) to give a yellow oil, the derivative Ik. The yield was 66%.
According to the analysis of related databases, 758-96-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Zhejiang University of Technology; Weng Jianquan; Xu Wenxiu; Dai Xiaoqiang; Liu Xinghai; (11 pag.)CN110432282; (2019); A;,
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