Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 148-18-5, Name is Sodium diethylcarbamodithioate, molecular formula is C5H10NNaS2, belongs to amides-buliding-blocks compound. In a document, author is Nagata, Takaya, introduce the new discover, Formula: C5H10NNaS2.
Beckmann rearrangement of ketoximes promoted by cyanuric chloride and dimethyl sulfoxide under a mild condition
Synthesis of amides via Beckmann rearrangement of ketoximes promoted by cyanuric chloride (TCT)/DMSO under mild conditions has been reported. Conditions of the Beckmann rearrangement, e.g., solvents, the ratios of TCT/DMSO, and the temperature, were investigated using diphenylmethanone oxime as a substrate. The optimized conditions were adopted to afford fourteen amides with yields ranging from 20% to 99%. A plausible mechanism involving an active dimethyl alkoxysulfonium intermediate was proposed according to the mass spectrometry analysis. To our best knowledge, this is the first case of study on Beckmann rearrangement of ketoximes promoted by TCT/DMSO under a mild condition to afford amides efficiently. (C) 2020 Elsevier Ltd. All rights reserved.
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