Synthetic Route of 13433-00-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 13433-00-6, Name is Diethyl 2-aminomalonate hydrochloride, SMILES is O=C(OCC)C(N)C(OCC)=O.[H]Cl, belongs to amides-buliding-blocks compound. In a article, author is Ahn, Jungbin, introduce new discover of the category.
Single-Step Synthesis of Iodinated Oxazoles from N-Propargyl Amides Mediated by I-2/lodosylbenzene/Trimethylsilyl Trifluoromethanesulfonate Systems
A combination of I-2, iodosylbenzene, and trimethylsilyl trilluoromethanesulfonate (TMSOTf) is effective for single-step, synthesis of iodinated oxazoles from N-propargyl amides via the aromatization of the iodocyclited intermediates, which has difficulty proceeding through conventional iodocyclization methods. Compared to the former method consisting of the metal-catalyzed cyclization of N-propargyl amides followed by halogenation of alkylideneoxazolines, the present reaction provides a facile and metal-free procedure.
Synthetic Route of 13433-00-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 13433-00-6.