Month: March 2021

Adding a certain compound to certain chemical reactions, such as: 115643-59-9, name is 2-Amino-6-fluorobenzamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 115643-59-9, Safety of 2-Amino-6-fluorobenzamide

An aromatic amine 1t-1 (0.20 mmol), a platensimycin acid (0.10 mmol), and2-(7-Azobenzotriazole)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (HATU) (0.30 mmol) was added to the reaction flask and 1.0 ml was added.N,N-dimethylformamide, stirring at room temperature; slowly adding triethylamine (0.45 mmol), stirring for 12 hours, rotary evaporationSolvent to obtain a crude product, which is subjected to column chromatography to obtain a platensimycin analog2t-1, yield 42%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Changsha Tianci Bio-pharmaceutical Technology Co., Ltd.; Changsha Cihang Pharmaceutical Institute Co., Ltd.; Ha Yao Cihang Pharmaceutical Co., Ltd.; Duan Yanwen; Shen Ben; Huang Yong; Zhu Xiangcheng; Qiu Lin; Tian Kai; (39 pag.)CN107793388; (2018); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 67442-07-3, name is 2-Chloro-N-methoxy-N-methylacetamide, molecular formula is C4H8ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 67442-07-3

Example 10l-(4-teri-butoxy-2-isopropoxy-l,3-benzothiazol-7- l)-2-chloro-ethanoneA solution of n-butyllithium in hexanes (1.6 M, 0.41 mL, 0.65 mmoles) was added dropwise to a pre-cooled (-50 ¡ãC) solution of 7-bromo-4-tert-butoxy-2-isopropoxy-l,3-benzothiazole XVII (225 mg, 0.59 mmoles) in methyl tert-butyl ether (2.5 mL) maintaining a temperature below -45 ¡ãC. The mixture was allowed to warm to -20 ¡ãC and left to stir for 30 minutes. A solution of 2-chloro-N-methoxy-N-methyl acetamide (122 mg, 0.89 mmoles) in methyl tert- butyl ether (2.5 mL) was then added dropwise maintaining a temperature below -15 ¡ãC and the mixture allowed to stir for 20 minutes. The reaction was then quenched by the addition of saturated ammonium chloride solution (2.0 mL) and water (10.0 mL). The aqueous phase was extracted with methyl fert-butyl ether (2 x 10 mL) and the combined organic phases were dried (MgSC^), filtered and evaporated to give a pale orange solid. Purification by flash chromatography (isohexane/EtOAc, 95/5 to 90/10) gave title compound XVI as a beige solid (120 mg, 0.35 mmoles).1H NMR (500 MHz, CDC13) delta 7.75 (d, J= 8.5 Hz, 1H), 7.11 (d, J= 8.5 Hz, 1H), 5.46 (hept, J= 6.2 Hz, 1H), 4.79 (s, 2H), 1.50 (s, 9H), 1.47 (d, J= 6.2 Hz, 6H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 67442-07-3, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BARNWELL, Neil; CORNWALL, Philip; GILL, Duncan, Michael; HOWELL, Gareth, P.; MEADOWS, Rebecca, Elizabeth; MERIFIELD, Eric; MITCHELL, Christopher, William; MURUGAN, Andiappan; O’KEEFE, Philip; PATEL, Zakariya, Mohamed; ROSE, James, Barry; SINGLETON, John; WITHNALL, Jane; WO2012/156693; (2012); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 53844-02-3, name is Benzyl (2-bromoethyl)carbamate, A new synthetic method of this compound is introduced below., Recommanded Product: 53844-02-3

The compound of Reference Example 55 (12.3 g) was dissolved in dimethylformamide (100 ml), and thereto were added cesium carbonate (15.3 g) and the compound of Reference Example 42 (8.75 g), and the mixture was vigorously stirred at 80C for 5 hours. The mixture was filtered to remove the cesium carbonate, and water was added to the filtrate, and extracted with ethyl acetate. The organic layer was washed with 1N hydrochloric acid and saturated aqueous sodium chloride solution, dried over sodium sulfate, filtered and concentrated under reduced pressure. The obtained residue was purified by silica gel column (ethyl acetate/hexane=1:2) to give the title compound (10.7 g). MS (ESI+) 649 (M++1, 40%).

The synthetic route of 53844-02-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; EP2447264; (2012); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22808-73-7, name is Methyl 4-sulfamoylbenzoate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C8H9NO4S

B. 4-(4-Oxo-2-m-tolyl-pentanoylsulfamoyl)-benzoic acid methyl ester. To a stirred solution of 4-sulfamoyl-benzoic acid methyl ester (6.01 g, 27.8 mmol), 4-oxo-2-m-tolyl-pentanoic acid (6.35 g, 30.7 mmol), N,N-diisopropylethylamine (12.2 mL, 69.5 mmol), and DMAP (5 mole %) in CH2Cl2 (275 mL) at rt under N2 was added bromo-tripyrrolidino-phosphonium hexafluorophosphate (PyBroP) (18.1 g, 38.9 mmol), and the reaction mixture was allowed to stir overnight. The mixture was diluted with 1 M HCl (100 mL) and CH2Cl2 (150 mL), and the layers were separated. The organic phase was washed with 1 M HCl (1*100 mL), 1N NaOH (1*100 mL) and brine (1*100 mL). The organic layer was dried over Na2SO4, and then filtered, and the solvent was removed under reduced pressure. Purification on silica gel (0-15% EtOAc in hexane) gave. 12.0 g (99%) of desired ester as a white solid. 1H NMR (400 MHz, CDCl3): 8.15 (d, J=8.6 Hz, 2H), 7.99 (d, J=8.6 Hz, 2H), 7.18 (t, J=7.6 Hz, 1H), 7.10 (d, J=7.6 Hz, 1H), 6.87 (m, 2H), 3.97 (s, 3H), 3.93 (dd. J=4.3 and 9.5 Hz, 1H), 3.29 (dd. J=9.5 and 18.1 Hz, 1H), 2.60 (dd. J=4.3 and 18.1 Hz, 1H), 2.28 (s, 3H), 2.07 (s, 3H).

The synthetic route of 22808-73-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Deng, Xiaohu; Mani, Neelakandha; Mapes, Christopher M.; US2006/4195; (2006); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 579474-47-8, name is tert-Butyl 2-amino-4-fluorophenylcarbamate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 579474-47-8, Recommanded Product: 579474-47-8

Example M4 {4-Fluoro-2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-4-fluoro-phenyl)-carbamic acid tert-butyl ester (Example J2) (83 mg, 0.37 mmol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic acid tert-butyl ester (Example K1) (109 mg, 0.37 mmol) according to the general procedure M. Obtained as a light yellow amorphous substance (127 mg). MS (ISP) 450 [(M+H)+].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 2-amino-4-fluorophenylcarbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Adam, Geo; Goetschi, Erwin; Wichmann, Juergen; Woltering, Thomas Johannes; US2003/166639; (2003); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

191170-76-0, name is Benzyl 4-bromophenethylcarbamate, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C16H16BrNO2

To a solution of benzyl 4-bromophenethylcarbamate (13.7 g, 41.1 mmol) in DMF (40 mL) was added Zn(CN)2 (4.93 g, 41.2 mmol) and Pd(PPh3)4 (4.75 g, 4.11 mmol). The reaction mixture was stirred at 100 C under Ni overnight. TLC showed the reaction completed. The reaction mixture was quenched with water and filtered. The residue was stirred in a mixed solvent of ethyl acetate and hexane (100 mL, EtOAc:Hexane = 1 :6) for 30 min. It was next filtered and dried to afford the title compound as white solid (8.9 g, 77.6%). NMR (500 MHz, DMSO- d6): 7.74 (d, 2H), 7.28-7.41 (m, 8H), 4.99 (s, 2H), 3.25-3.29 (m, 2H), 2.81 (t, 2H).

The synthetic route of 191170-76-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ZHEJIANG VIMGREEN PHARMACEUTICALS, LTD; SUN, Sanxing; YE, Jinqi; ZHAO, Long; HU, Chongbo; CHEN, Zhengshu; (0 pag.)WO2020/2968; (2020); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17641-08-6, name is 2-Chloro-N-(3-methoxyphenyl)acetamide, A new synthetic method of this compound is introduced below., Safety of 2-Chloro-N-(3-methoxyphenyl)acetamide

General procedure: Various substituted anilines were dissolved in glacial acetic acid at0 C, to this was added over 30 min choloroacetyl chloride (2 equivalents).The reaction mixture was brought to room temperature andstirred overnight. Saturated sodium bicarbonate solution was added tillcomplete neutralization. The resulting precipitate was filtered off andwashed with n-hexane and dried. The resultant product (1) was usedfurther without any purification. Either of 4-hydroxy benzaldehyde(2a), vanillin (2b) or isovanillin (2c) (1 equivalent) was dissolved inacetone and potassium carbonate (2 equivalents) was added. Thencorresponding substituted acetamide (1) was mixed to the stirring solution.Finally, potassium iodide (1.5 equivalent) was added. The reactionmixture was refluxed for 8-10 h. After completion of reaction,the resultant mixture was concentrated and treated with water andextracted with ethyl acetate (3¡Á20 mL). The organic layers werecombined and treated with brine and dried over sodium sulfate andconcentrated. The crude mixture was purified over silica gel (60-120)using petroleum ether: ethyl acetate (9:1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Sonawane, Vinay R.; Siddique, Mohd Usman Mohd; Gatchie, Linda; Williams, Ibidapo S.; Bharate, Sandip B.; Jayaprakash, Venkatesan; Sinha, Barij N.; Chaudhuri, Bhabatosh; European Journal of Pharmaceutical Sciences; vol. 131; (2019); p. 177 – 194;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

4943-86-6, name is 2-Amino-N-(4-chlorophenyl)benzamide, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C13H11ClN2O

General procedure: A flask was charged with 2-aminobenzamide (1a; 27.2 mg, 0.2 mmol), pentane-2,4-dione (2A;30.0 mg, 0.3 mmol), FeCl3¡¤6H2O (10.8 mg, 0.04 mmol), and PEG-400/H2O (1.0 mL, 1:9 (v/v)).The reaction was stirred at 100 C for 24 h. When the reaction was complete monitored by TLC,the mixture was cooled to room temperature, extracted with EtOAc (3¡Á20 mL). The combined organic phase was washed with water, dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the product 3aA (29.3 mg, 91%) as white solid.

The synthetic route of 4943-86-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shen, Guanshuo; Zhou, Haifeng; Sui, Yuebo; Liu, Qixing; Zou, Kun; Tetrahedron Letters; vol. 57; 5; (2016); p. 587 – 590;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16091-26-2, name is 3′-Aminobenzanilide, A new synthetic method of this compound is introduced below., Recommanded Product: 3′-Aminobenzanilide

General procedure: Compound (1a-e) (1 eq.) and compound (2a-e) (1 eq.) were suspendedin 5 mL of glacial acetic acid. The suspension dissolved completely uponheating. The reaction was refluxed for 15-30 min. After completion ofreaction (as monitored by TLC), reaction mixture was allowed tocooled, and then 10 mL of water was added. The resulting precipitatewas then filtered and was washed with water, cold ethanol, and hexanesto give the product.25N-(3-(2-methyl-4-oxoquinazolin-3(4H)-yl)phenyl) benzamide (4a):TLC carried out in Hexane: Ethyl acetate (60:40) Rf=0.13; cream colorsolid (70%); M.P: 248-249 C; IR: 3290 cm-1 (NeH stretch),1658 cm-1 (C]O amide); HRMS: m/z calcd for C22H17N3O2: 355.39[M+H]+; found: 356.1565.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Qureshi, Shahnawaz I.; Chaudhari, Hemchandra K.; Bioorganic and Medicinal Chemistry; vol. 27; 12; (2019); p. 2676 – 2688;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 63920-73-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63920-73-0, name is 2-Amino-4,6-dimethoxybenzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Aniline 12 (37 mg, 0.188 mmol) and 14ba (47.0 mg, 0.188 mmol) weredissolved inDMAc (1.0 mL) and treated with sodium hydrogen sulfite (23.5mg,0.23 mmol) and PTSA (7.2 mg, 0.04 mmol). The reactionmixture was stirred at 120C for 16 h. Water was added to thereaction, and the precipitated solid wascollected by filtrationto give 15ba(69.0 mg, 86%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-4,6-dimethoxybenzamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Shao, Mingfeng; He, Linhong; Zheng, Li; Huang, Lingxiao; Zhou, Yuanyuan; Wang, Taijing; Chen, Yong; Shen, Mingsheng; Wang, Fang; Yang, Zhuang; Chen, Lijuan; Bioorganic and Medicinal Chemistry Letters; vol. 27; 17; (2017); p. 4051 – 4055;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics