Month: March 2021

Synthetic Route of 1268810-09-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1268810-09-8, name is tert-Butyl (1-ethynylcyclopropyl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

tert-Butyl (1-ethynylcyclopropyl )carbamate (200.0 mg, 1.104 mmol) was treated with azidotrimethyl silane (508.6 mg, 4.414 mmol, 4 equiv.) in the presence of copper iodide (21.0 mg, 0.11 mmol) in N,N-dimethylformamide (1 mL) and methanol (1 mL) and stirred at 110 C for 2 h. After cooling, purification by prep HPLC gave fert-butyl (1-(1H-1,2,3- triazol-4-yl)cyclopropyl)carbamate. LCMS-ESI+ (m/z): [M+H] + calculated for C10H17N4O2: 225.1 ; found: 225.1 .

The synthetic route of tert-Butyl (1-ethynylcyclopropyl)carbamate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GILEAD SCIENCES, INC.; GUTIERREZ, David A.; KOBAYASHI, Tetsuya; LAZERWITH, Scott E.; LEE, Rick A.; MORGANELLI, Philip A.; PYUN, Hyung-Jung; (0 pag.)WO2019/165374; (2019); A1;,
Amide – Wikipedia,
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Reference of 63920-73-0, The chemical industry reduces the impact on the environment during synthesis 63920-73-0, name is 2-Amino-4,6-dimethoxybenzamide, I believe this compound will play a more active role in future production and life.

To a solution of 2-amino-4,6-dimethoxy-benzamide (7.50 g, 38.2 mmol) and 3-(2-hydroxy-ethoxy)-5-methoxy-benzaldehyde (7.50 g, 38.2 mmol) in N,N-dimethylacetamide (30 mL) was added NaHSO3 (58.5 wt %, 4.37 g, 42.0 mmol) and p-TSA (0.72 g, 3.8 mmol). The reaction mixture was heated to 115-120 C. for 16 hours, and then cooled to room temperature. N,N-dimethylacetamide was removed under reduced pressure, the residue was diluted with water (50 mL), and the solid was filtered, collected, and mixed with ether (50 mL), then filtered and dried under vacuum, to give 2-[3-(2-hydroxy-ethoxy)-5-methoxy-phenyl]-5,7-dimethoxy-3H-quinazolin-4-one as a white solid. Yield: 10 g (70%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-4,6-dimethoxybenzamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Resverlogix Corp.; Hansen, Henrik C.; (96 pag.)US9238640; (2016); B2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 141449-85-6,Some common heterocyclic compound, 141449-85-6, name is tert-Butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate, molecular formula is C11H20N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference Example 35: 5-(4-ChIoro-6-morphoIin-4-vI-pyrimidin-2-vImethyl)- hexahydro-pyrroloP.lambda-cipyrrole^-carboxylic acid tert- butyl ester; To a solution of 4-(2-bromomethyl-6-chloro-pyrimidin-4-yl)-morpholine (230 mg,0.786 mmol) in DMF (10 mL) were added potassium carbonate (212 mg, 1.53 mmol) and hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester (250 mg, 1.18 mmol). The mixture was stirred at RT for 30 min. The reaction mixture was diluted with water then extracted into EtOAc. The organic layer was washed with brine, dried (MgSO4) and concentrated in vacuo. The resultant residue was purified by column chromatography to give the title compound as a colourless oil (332 mg, 100 %). [M + H]+ 424.3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate, its application will become more common.

Reference:
Patent; PIRAMED LIMITED; THE INSTITUTE OF CANCER RESEARCH; WO2008/125833; (2008); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 108468-00-4, name is 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene, A new synthetic method of this compound is introduced below., Recommanded Product: 108468-00-4

HOBT (1.45 g, 10.9 mmol) is added to a solution of {3-[3-(3-carboxymethoxyprop-1-ynyl)phenyl]prop-2-ynyloxy}acetic acid (A30, 0.40 g, 1.3 mmol) and 4-N-tert-butoxycarbonylaminomethylbenzylamine (1.2 g, 5.2 mmol) in absolute CH2Cl2 (20 ml) and Et3N (2.5 ml), and the mixture is stirred at RT for 45 min. EDC (2.1 g, 10.9 mmol) is then added, and the mixture is stirred at RT overnight. The reaction solution is diluted with CH2Cl2 (15 ml) and extracted (2¡Á) with semisaturated aqueous NH4Cl solution (25 ml), dried over MgSO4, filtered off and concentrated under reduced pressure. Further purification by chromatography [Tol/Ac (8:2)] over a silica gel column gives the title compound (1.1 g) as a colorless powder. TLC, silica gel, glass plates, [Tol/Ac (7:3)], Rf=0.51.MS: calc.: C42H50N4O8 (738.0), found: [MH+] 738.8, [MNH4+] 755.8; [MNa+] 761.2

The synthetic route of 108468-00-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Altana Pharma AG; US6960588; (2005); B1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 1259224-00-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1259224-00-4, name is tert-Butyl (1-(4-aminophenyl)cyclobutyl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 2-chloro-3-(2-phenylethynyl)pyridine (426 mg, 2 mmol),Pd2(dba)3 (90 mg, 0.1 mmol), X-phos (190 mg, 0.4 mmol) and Cs2C03 (978 mg, 3 mmol) in Dioxane (8mL) was added tert-butyl l-(4-aminophenyl)cyclobutylcarbamate (524 mg, 2 mmol). The mixture degassed and charged with N2 for three times. And then the resulting mixture was stirred at 120 C for 60min by microwave irradiation. The reaction mixture was filtered by filter paper. The filtrate was concentrated under reduced pressure to get crude product, which was purified by flush column chromatography on silica gel (eluting with petroleum ether/ethyl acetate=l 00/1 -1/1) to yield the desired product tert-butyl l-(4-(3-(2-phenylethynyl)pyridin-2- ylamino)phenyl)cyclobutylcarbamate (220 mg, 25% yield^HNMR: MeOD 400MHz ? 8.08(s, lH), 7.71~7.69(d, 1H, J=8), 7.57~7.53(m, 4H), 7.38-7.36 (m, 5H), 6.75 (s, lH), 2.80-2.76 (m, 4H), 2.15-2.00 (m, 1H), 1.95-1.82 (m, 1H), 1.36 (s, 9H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (1-(4-aminophenyl)cyclobutyl)carbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; SKELTON, Nicholas; GRADL, Stefan; BLAKE, James F.; GRAHAM, James M.; GUNAWARDANA, Indrani W.; HENTEMANN, Martin; MARLOW, Allison L.; TANG, Tony P.; WO2013/78254; (2013); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 40545-33-3,Some common heterocyclic compound, 40545-33-3, name is 2-Amino-5-methylbenzamide, molecular formula is C8H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 3 To a solution of 2-amino-5-methylbenzamide (5.80 g, 38.6 mmol) and triethylamine (4.69 g, 46.3 mmol) in THF (200 mL) was added dropwise ethyl chloroglyoxylate (5.80 g, 42.5 mmol) under ice-cooling, and the mixture was stirred at room temperature for 3 hr. The reaction mixture was diluted with ethyl acetate, washed with water and saturated brine, dried over sodium sulfate, and concentrated under reduced pressure. The residue was washed with ethanol to give ethyl ((2-(aminocarbonyl)-4-methylphenyl)amino)(oxo)acetate as a white powder (9.83 g, 100%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Amino-5-methylbenzamide, its application will become more common.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1953148; (2008); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 25900-61-2, name is 3-Amino-N-methylbenzamide, molecular formula is C8H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 3-Amino-N-methylbenzamide

A solution of 7-methanesulfinyl-3-(2,6-dichloro-phenyl)-1-methyl-1H-pyrimido[4,5-e][1,3,4]oxadiazine (0.10 g, 0.28 mmol), N-methyl-3-amino-benzamide (84 mg, 0.56 mmol) and p-toluenesulfonic acid monohydrate (53.3 mg, 0.28 mmol) (Aldrich) in isopropanol (4 ML) was placed in a microwave reactor (SmithSynthesizer).The reaction mixture was heated at 170 C. for 1 h.The reaction mixture was concentrated and purified by RP-HPLC (C-18, eluding with MeCN/H2O) to obtain a solid which was recrystallized from methanol to afford the product. (Yield 34 mg, 28%). HRMS m/z Calculated for C20H16Cl2N6O2 [(M+H)+]: 443.0785. Found: 443.0791.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 25900-61-2, its application will become more common.

Reference:
Patent; Chen, Jian Jeffrey; Luk, Kin-Chun Thomas; US2004/97493; (2004); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 72080-83-2, name is Benzyl (2-aminoethyl)carbamate, A new synthetic method of this compound is introduced below., Quality Control of Benzyl (2-aminoethyl)carbamate

EDCI (260 mg, 1.35 mmol), HOBt (8 mg, 61 mumol) were added to a solution of diacid 12 (200 mg, 0.613 mmol) in CHCI3 (8 ml_) and the solution stirred for 5 minutes at room temperature. A solution of benzyl (2-aminoethyl)carbamate (262 mg, 1 .35 mmol) in CHCI3 (2 ml_) was added and the solution stirred at room temperature overnight. Water (25 ml_) was added and the aqueous phase extracted with EtOAc (3 * 30 ml_), the combined organic phases were washed with brine (1 * 30 ml_), dried (MgSO4) and the solvent removed to give a white resin. Analysis of the crude resin by 1H NMR spectroscopy indicated the presence of the desired compound, . purification by silica gel chromatography (EtOAc/Petrol 1 :1 ->; EtOAc/MeOH 9.5:0.5) gave diamide 13 (261 mg, 63%) as a white gum. umax (thin film/cm’1) 3341.8, 3067.4, 2926.3, 2855.1 , 1703.8, 1644.3, 1542.5, 1455.3, 1263.5, 1 145.6, 1034.5; deltaH (270 MHz, CDCI3) 7.56 (2H, br s, NH), 7.40 (1 H, br s, NH), 7.20 – 7.35 (10H, m), 6.00 (2H, br s, NH), 5.02 (4H, br s), 4.59 (1 H, t, J 4.7 Hz), 4.03 (1 H, d, J 4.8 Hz), 3.97 (1 H, d, J 4.8 Hz), 3.10 – 3.42 (8H, m), 2.45 – 2.60 (3H, m), 1.73 (1 H, d, J 10.0 Hz), 1.50 – 1.60 (2H, m, OCH2) 1.49 (1 H, d, J 10 Hz), 1.23 (10H, m), 0.85 (3H, m); deltac (67.5 MHz, CDCI3) 174.7, 172.6, 157.2 (x 2), 136.5, 128.6 (x 5), 128.2 (x 2), 128.1 (x 5), 104.0, 81 .6. 78.8, 66.9, 66.8, 46.6, 46.3, 44.0 (x 2), 40.7, 39.9, 39.7, 33.0, 32.1 , 31.9, 29.6, 29.3, 24.3, 22.7, 14.2; HRMS (+ve) Calcd for C37H5IN4O8 679.3701 [M+H] found 679.3724.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; DEAKIN UNIVERSITY; PFEFFER, Frederick; HENDERSON, Luke; LI, Jian; NATION, Roger; WO2010/99573; (2010); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 67442-07-3, These common heterocyclic compound, 67442-07-3, name is 2-Chloro-N-methoxy-N-methylacetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

n-Butyllithium (2.5 M in hexane, 2.58 mL, 6.44 mmol) was added dropwise to a mixture of diisopropylamine (0.87 mL, 6.18 mmol) in Et20 (30 mL) at -10 ¡ãC. After 30 min the mixture was cooled to -60 ¡ãC and a solution of 3-fluoropyridine (0.44 mL, 5.15 mmol) in Et20 (10 mL) was added dropwise at -60 ¡ãC. After 45 min a solution of 2-chloro-/V-methoxy-//- methylacetamide (708.49 mg, 5.15 mmol)l in Et20 (10 mL) was added dropwise at -60 ¡ãC and the mixture was stirred at -60 ¡ãC for 1 h. The cooling bath was removed and NH4CI (aq, 10 percent, 20 mL) was carefully added. The organic phase was collected, diluted with EtOAc, washed with NH4CI (aq, 10 percent), brine, dried (Na2S04), filtered through silica gel and concentrated. The residue was partitioned between H2O and CH2CI2 and the aq phase was washed with CH2CI2. The combined organic phases were dried (Na2S04) and concentrated to give the sub-title compound (750 mg, 4.32 mmol, 84 percent).

The synthetic route of 67442-07-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ATROGI AB; PELCMAN, Benjamin; BENGTSSON, Tore; (93 pag.)WO2019/53427; (2019); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 106984-09-2, A common heterocyclic compound, 106984-09-2, name is tert-Butyl (2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)carbamate, molecular formula is C13H27NO6, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

This oil was dissolved in DCM and treated with p-toluenesulfonyl chloride (1.18 g, 6.21 mmol) and pyridine (0.84 mL, 10.4 mmol). After stirring at 40 C for 12 h, the mixture was diluted with DCM and washed with iN HC1 (2 x 10 mL), H20 (10 mL), and brine (10 mL), then dried over Na2SO4 and concentrated. Purification via flash column chromatography on silica gel gave 330 mg (36% yield over 2 steps) of the tosylate as a colorless oil.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH; THE SCRIPPS RESEARCH INSTITUTE; SHEN, Weijun; SCHULTZ, Peter, G.; MUPPIDI, Avinash; CRAMERI, Andreas; AHMAD, Insha; YANG, Pengyu; WO2015/38938; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics