Application of 6292-59-7, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 6292-59-7, Name is 4-(tert-Butyl)benzenesulfonamide, SMILES is C1=CC(=CC=C1C(C)(C)C)[S](N)(=O)=O, belongs to amides-buliding-blocks compound. In a article, author is Kumar, Prabhat, introduce new discover of the category.
Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor
We previously reported the 2-oxopyridine-3-carboxamide derivative EC21a as the first small synthetic CB2R positive allosteric modulator which displayed antinociceptive activity in vivo in an experimental mouse model of neuropathic pain. Herein, we extended the structure-activity relationships of EC21a through structural modifications regarding the p-fluoro benzyl moiety at position 1 and the amide group in position 3 of the central core. The characterization in vitro was assessed through radioligand binding experiments and functional assays (GTP gamma S, cAMP, beta arrestin2). Among the new compounds, the derivatives Al (SV-10a) and A5 (SB-13a) characterized respectively by fluorine atom or by chlorine atom in ortho position of the benzylic group at position 1 and by a cycloheptane-carboxamide at position 3 of the central core, showed positive allosteric behavior on CB2R. They enhanced the efficacy of CP55,940 in [S-35]GTP gamma S assay, and modulated CP55,940-dependent beta arrestin2 recruitment and cAMP inhibition. The obtained results extend our knowledge of the structural requirements for interaction with the allosteric site of CB2R. (C) 2020 Elsevier Masson SAS. All rights reserved.
Application of 6292-59-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 6292-59-7 is helpful to your research.