Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 15761-38-3, Name is Boc-Ala-OH, molecular formula is C8H15NO4, belongs to amides-buliding-blocks compound, is a common compound. In a patnet, author is Wang, Yang, once mentioned the new application about 15761-38-3, Computed Properties of C8H15NO4.
Site-selective C-H bond carbonylation with CO2 and cobalt-catalysis
Utilization of anthropogenic greenhouse gas CO2 for catalytic C-C bond formation via conversion to essentially valuable C1 synthons like CO is very challenging. The requirement of an efficient catalyst that has the ability to convert CO2 into CO and activate inert C-H bonds is the bottleneck. We herein demonstrate a tandem approach accomplished in a two-chamber system for efficient fluoride-mediated generation of CO from CO2 using disilane as a deoxygenating reagent and utilization of the in situ-produced CO gas for C-H bond carbonylation using earth-abundant cobalt catalysts. The ease of handling CO2 gas at atmospheric pressure allows us to prepare C-13 labelled compounds which are otherwise difficult to achieve. The procedure developed makes it possible to utilize CO2 as a CO source, which can be widely applied as a C1 synthon that can be incorporated between C-H and N-H bonds of aromatic, hetero-aromatic and aliphatic carboxamides for the synthesis of various cyclic imides including spirocycles in a site-selective fashion. The late-stage derivatization of a well-known angiotensin receptor blocker (ARB), Telmisartan, and a well-known drug for very low-density lipoproteins (VLDLs), Gemfibrozil, is demonstrated. Further, to showcase the generality of the reaction, various pharmacologically important and privileged scaffolds like xanthone, coumarin and isatin have been synthesized with CO2 under atmospheric pressure.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 15761-38-3. The above is the message from the blog manager. Computed Properties of C8H15NO4.