In an article, author is Miyahara, Masayoshi, once mentioned the application of 5680-80-8, Name is H-Ser-OMe.HCl, molecular formula is C4H10ClNO3, molecular weight is 155.58, MDL number is MFCD00063680, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, Product Details of 5680-80-8.
Cocrystal of nutraceutical sinapic acid with Active Pharmaceutical Ingredients ethenzamide and 2-chloro-4-Nitrobenzoic acid: Equilibrium solubility and stability study
Sinapic acid (SNP) is a nutraceutical compound of hydroxybenzoic acid derivative which possesses antioxidant, anti-microbial, anti-inflammatory, anti-cancer, and anti-anxiety activity properties. In the present work, two cocrystals of SNP with two active drug ingredients such as Ethenzamide (ETZ) and 2-chloro-4-nitrobenzoic acid (CNB) are reported. Both the cocrystals were synthesized via simple solvent evaporation method and the crystal structures were characterized by Single Crystal X-ray Diffraction (SC-XRD) techniques. The cocrystals were formed via robust acid-amide heterosynthon and acid acid homosynthon between SNP and drug molecules. Both the cocrystals were crystallized in monoclinic crystal system with P 2(1)/c space group. The synthesized cocrystals were further characterized by DSC, PXRD, FT-IR, and H-1 NMR techniques. The solubility study in purified distilled water and in 0.1 N HCI solution demonstrate that there was no increment in the solubility of drug molecules in the cocrystals in both purified water and in 0.1 N HCl solution. The synthesized cocrystal exhibited six months stability at ambient conditions (similar to 25 degrees C, 60-65% RH). (C) 2018 Elsevier B.V. All rights reserved.
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