Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 25197-96-0, Name is (S)-2-Amino-3-(5-methoxy-1H-indol-3-yl)propanoic acid, molecular formula is C12H14N2O3, belongs to amides-buliding-blocks compound, is a common compound. In a patnet, author is Cao, Xiaoyan, once mentioned the new application about 25197-96-0, Name: (S)-2-Amino-3-(5-methoxy-1H-indol-3-yl)propanoic acid.
Microconine [N-methyl-2-methyl-3-methoxy-6-(deca-l’,3 ‘,5 ‘-trienyl) piperidine, an alkaloid from Microcos paniculata]: Synthesis, stereochemistry and spectroscopic data
Unambiguously corrected H-1 NMR data for the originally isolated sample of microconine [N-methyl-2-methyl-3-methoxy-6-(deca-l’,3′,5′-trienyl)piperidine], an alkaloid found in Microcos paniculata, are reported. The asymmetric synthesis of the (2S,3R,6S)- and (2S,3S,6S)-stereoisomeric forms [epimeric at C(3)] of this compound allows the unambiguous assignment of the relative 2,3-cis-3,6-cis-configuration of the natural product. The synthesis uses the conjugate addition of enantiopure lithium (S)-N-benzyl-N-(alpha-methylbenzyl)amide to tert-butyl crotonate and ensuing enolate oxidation with (+)-camphorsulfo-nyloxaziridine to generate the requisite C(2) and C(3) stereogenic centres found within the target. After elaboration, an intramolecular reductive amination was used to form the piperidine ring, with concomitant formation of the C(6) stereogenic centre. Comparison of specific rotation data is consistent with the alkaloid having the absolute (2R,3R,6R)-configuration. (C) 2020 Published by Elsevier Ltd.
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