In an article, author is Ivanova, Bojidarka, once mentioned the application of 112-84-5, Name is Erucamide, molecular formula is C22H43NO, molecular weight is 337.58, MDL number is MFCD00882379, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, SDS of cas: 112-84-5.
We report a stereoretentive cross-coupling reaction of configurationally stable nucleophiles with disulfide and N-sulfenylsuccinimide donors promoted by Cu(I). We demonstrate the utility of this method in the synthesis of thioglycosides derived from simple alkyl and aryl thiols, thioglycosides, and in the glycodiversification of cysteine residues in peptides. These reactions operate well with carbohydrate substrates containing common protective groups and reagents with free hydroxyl and secondary amide functionalities under standardized conditions. Competition experiments in combination with computational DFT studies established that the putative anomeric intermediate is an organocopper species that is configurationally stable and resistant to epimerization due to its short lifetime. The subsequent reductive elimination from the Cu(III) intermediate is rapid and stereoretentive. Taken together, the glycosyl cross-coupling is ideally suited for late stage glycodiversification and bioconjugation under highly controlled installation of the aliphatic carbon-sulfur bonds.
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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics