Let’s face it, organic chemistry can seem difficult to learn, Name: Z-Pro-OH, Especially from a beginner’s point of view. Like 1148-11-4, Name is Z-Pro-OH, molecular formula is amides-buliding-blocks, belongs to amides-buliding-blocks compound. In a document, author is Li, Tao, introducing its new discovery.
With an aim to develop potent lead molecules as a novel class of reverse transcriptase (RT) inhibitors, we have synthesized amide and ether conjugates of 2,3-diaryl-1,3-thiazolidin-4-one derivatives. The compounds 9a and 9f exhibited IC50 values of 0.21113 +/- 0.013 mu M and 12.6804 +/- 0.062 mu M respectively from the in vitro human immunodeficiency virus type 1 (HIV-1) RT assay. None of the compounds showed toxicity towards peripheral blood mononuclear cells (PBMC). Structure-activity relationship (SAR) studies were performed for the synthesized compounds in order to estimate the effect of the substitution pattern on the RT inhibition potency. In silico docking studies revealed that two or more interactions are necessary for significant activity.
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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics