Reference of 138-41-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 138-41-0, Name is Carzenide, SMILES is C1=C(C=CC(=C1)[S](N)(=O)=O)C(O)=O, belongs to amides-buliding-blocks compound. In a article, author is do Couto, Rene Oliveira, introduce new discover of the category.
Tryptophan-conjugated graphene quantum dots (Trp-GQDs) were fabricated for the first time and loaded with curcumin (Cur) as a hydrophobic anticancer agent, to evaluate Cur loading capacity and release kinetics, as well as its cytotoxicity effect on human breast cancer cells. The GQDs were synthesized through a facile oxidation method, Trp was conjugated onto GQDs via amide bonds and Cur was loaded onto GQDs and Trp-GQDs by noncovalent interactions. TEM, FESEM, PL, UV-Vis, and FTIR analysis were used to study the nano-assemblies structural and spectral characterizations. The drug loading capacity increased by increasing the initial concentration of Cur, and by 23% after the conjugation of GQDs with Trp. A pH-sensitive release was also detected at pH 5.5 and 7.4. Moreover, the experimental release data of Cur from the two nano-assemblies at both pHs had the best compliance with the pseudo-second-order model. In-vitro cellular cytotoxicity on MCF-7 cells demonstrated the nontoxicity of the bare GQDs and Trp-GQDs nanocarriers. Considering the biocompatibility, traceability, high drug loading capacity, and pH-sensitivity of Trp-GQDs nanocarrier, it can be concluded that Cur/Trp-GQDs can be regarded as a promising candidate for drug delivery applications.
Reference of 138-41-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 138-41-0.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics