Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 70-47-3, Name is H-Asn-OH, SMILES is O=C(O)[C@@H](N)CC(N)=O, belongs to amides-buliding-blocks compound. In a document, author is Contente, Martina Letizia, introduce the new discover, Application In Synthesis of H-Asn-OH.
Mapping conformational changes of alpha-synuclein (alpha-syn) from soluble, unstructured monomers to beta-sheet-rich aggregates is crucial towards understanding amyloid formation. Raman microspectroscopy is now used to spatially resolve conformational heterogeneity of amyloid aggregates and monitor amyloid formation of segmentally C-13-labeled -syn in real-time. As the C-13-isotope shifts the amide-I stretching frequency to lower energy, the ligated construct, (C1-86CS87C-140)-C-13-C-12-alpha-syn, exhibits two distinct bands allowing for simultaneous detection of secondary structural changes in N-terminal 1-86 and C-terminal 87-140 residues. The disordered-to-beta-sheet conformational change is first observed for the N-terminal followed by the C-terminal region. Finally, Raman spectroscopic changes occurred prior to Thioflavin T fluorescence enhancement, indicating that the amide-I band is a superior probe of amyloid formation.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 70-47-3 is helpful to your research. Application In Synthesis of H-Asn-OH.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics