Month: July 2021

Adding a certain compound to certain chemical reactions, such as: 37045-73-1, name is 3-(Methylsulfonamido)aniline, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37045-73-1, category: amides-buliding-blocks

Under nitrogen or argon, 0.4 mmol, 0.2mmol, Ir(ppy) 3(2mg) and DMF1 ml was added to the reaction flask, followed by blue LED lights(7W) at room temperature irradiation straight trivalent iodine reagent completeconversion of the reaction. Add 10 ml of saturated Na 2CO 3Aqueous solution, andextracted three times with ethyl acetate, the organic layer was washed with water andonce with saturated brine, dried over anhydrous Na 2SO 4The organic layer was dried.Column chromatography (eluent: petroleum ether 60-90: ethyl acetate = 10: 1-5: 1) to Ethyl acetate = 10: 1-5: 1) to give the product , S; Yield 43%.Rate of 19%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Nanjing University; Zhu, ChengJian; Xie, jin; Xu, Pan; (13 pag.)CN103553857; (2016); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 5466-88-6,Some common heterocyclic compound, 5466-88-6, name is 2H-1,4-Benzoxazin-3(4H)-one, molecular formula is C8H7NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 4H-Benzo[1,4]oxazin-3-one (2.5 g, 16.77 mmol) in DMF (10 mL) was added potassium tert-butoxide (2.81 g, 25.16 mmol) at 0 C. After stirring for 5 min, methyl iodide (3.54 g, 25.16 mmol) was added and the reaction mixture was stirred for another 3h. The reaction was quenched by addition of water and extracted with ethyl acetate (30 x 2 mL). The organic layer was washed with water (20 mL), and evaporated to get a crude product 2.2 g.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2H-1,4-Benzoxazin-3(4H)-one, its application will become more common.

Reference:
Patent; NOVARTIS AG; BEBERNITZ, Gregory, Raymond; BOCK, Mark, G.; REDDY, Dumbala Srinivas; HAJARE, Atul Kashinath; VYAVAHARE, Vinod; BHOSALE, Sandeep Bhausaheb; KURHADE, Suresh Eknath; SALUNKHE, Videsh; SHAIKH, Nadim, S.; BHUNIYA, Debnath; PALLE, P., Venkata; FENG, Lili; LIANG, Jessica; WO2011/48112; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 142-26-7, name is N-Acetylethanolamine, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 142-26-7, Recommanded Product: N-Acetylethanolamine

EXAMPLE 11 2-(Acetylamino)-9(Z)-octadecenoate, 15 To a solution of 1.0 g of oleoyl chloride in 10 ml of tetrahydrofuran was added a solution of 0.42 g of N-acetyl ethanolamine and 2 ml of triethylamine in 15 ml of tetrahydrofuran. This mixture was stirred for 12 hours, then poured into water and extracted with ether. The ether extract was washed with 2N hydrochloric acid and brine, then dried and evaporated. The residual yellow oil was purified by flash chromatography, eluding with hexane:ethyl acetate (2:1), giving 0.32 g of the desired product as a pale yellow oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Acetylethanolamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; American Cyanamid Company; US5053426; (1991); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 104060-23-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 104060-23-3 name is N-Boc-2-(4-Aminophenyl)ethanol, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

This compound (1.5 g, 8.6 mmol) was suspended in dry tetrahydrofuran (20 mL) at EPO 250C. The 4-(N-l-terf-butyloxycarbonyl)-aminophenethyl alcohol (3.4 g, 14.5 mmol) and triphenylphosphine (3.8 g, 14.5 mmol) were then added, and the mixture evaporated to dryness. Dry tetrahydrofuran (20 mL) was added and the suspension was cooled to 0C before dropwise addition of diethylazodicarboxylate (1.5 mL, 9.8 mmol). After 16 h reaction at room temperature, the solution was concentrated under reduced pressure. The crude residue was purified on a BIOTAGE 25M column (silica, hexane/AcOEt 95:5 to 75:25) to yield N-9 alkylated purine as a white solid (2.9 g, 87%). To a solution of alkylated 2-fluoro-6-chloropurine (3.0 g, 7.7 mmol) in n- butanol (15 mL) at 250C was added N- 1-tert-butyloxycarbonyl- 1,3 -phenyl enediamine (1.8 g, 8.8 mmol) and diisopropylethylamine (2.7 mL, 15.3 mmol). After 48 h reaction at 65C, the brown solution was concentrated under reduced pressure. The crude residue was purified on a BIOTAGE 4OM column (silica, hexane/ AcOEt 65:45 to 0:1) to yield the fluoropurine derivative as a brown solid (2.8 g, 63%). To a solution of this product (2.8 g, 4.9 mmol) in n-butanol (15 mL) at room temperature was added aminomethylcyclopropane (1.2 g, 17.1 mmol) and diisopropylethylamine (1.7 mL, 9.8 mmol). After 48 h reaction at 1100C, the brown solution was concentrated under reduced pressure. The crude residue was purified on a BIOTAGE 4OM column (silica, hexane/ AcOEt 60:40 to AcOEt/MeOH 98:2) to yield the protected trisubstituted purine as a white solid (2.3 g, 73%). To a solution of this compound (2.08 g, 3.38 mmol) in dichloromethane (10 mL) at room temperature was added 4N HCl in dioxane (10 mL). The reaction was stirred for 5 h at 25C and the solution was concentrated under reduced pressure. The solid was then dried for 16 h under vacuum to yield compound 3 as a brown solid. Yield of product: 1.4 g (quantitative); Rf = 0.1 (CH2Cl2/Me0H 98:2); 1H NMR (400 MHz, CD3OD): delta 8.24 (s, IH), 8.20-7.60 (m, 2H), 7.60-7.00 (m, 6H), 4.56 (t, 2H, J= 7.0 Hz), 3.40-3.20 (m, 4H), 1.25-1.15 (m, IH), 0.60-0.50 (m, 2H), 0.40-0.20 (m, 2H); LRMS (ESI): m/z 415 (MH+), 437 (M+ Na); HPLC (method 2): 1.6 min.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-Boc-2-(4-Aminophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; PROMETIC BIOSCIENCES INC.; WO2006/136005; (2006); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Mu, Youbing, once mentioned the application of 148-18-5, Name is Sodium diethylcarbamodithioate, molecular formula is C5H10NNaS2, molecular weight is 171.2594, MDL number is MFCD00041028, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, COA of Formula: https://www.ambeed.com/products/148-18-5.html.

This article presents the synthesis of a series of amides, based on the interaction of several 3-aminospirohydantoins with nalidixic acid. The target compounds were characterized by physicochemical parameters, IR, H-1 and C-13 NMR spectral data. The antimicrobial activity of the products obtained was determined against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, Gram-negative bacteria Escherichia coli, Pseudomonas aeruginosa and Salmonella abony, the yeasts Candida albicans and Saccharomyces cerevisiae and the molds Penicillium chrysogenum and Aspergillus niger. The relationship between structure and biological activity of the products obtained was discussed. It was found that the most effective compounds are tetralin (5f) and indane (5g) derivatives, which exhibit a pronounced antimicrobial activity against both tested Gram-positive and Gram-negative bacteria.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 148-18-5, COA of Formula: https://www.ambeed.com/products/148-18-5.html.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 104-63-2, Name is 2-(Benzylamino)ethanol, SMILES is OCCNCC1=CC=CC=C1, in an article , author is Zhang, Zexin, once mentioned of 104-63-2, Recommanded Product: 104-63-2.

Self-assembled diphenylalanine (FF) nanostructures have recently been demonstrated to be interesting materials for antibacterial and anticancer applications. These applications, among others, seek to take advantage of the high-order and resulting appealing physical properties of FF nanostructures by modifying the peptide in some way to achieve specific functionality. To rationally design modifications to the dipeptide that allow for this behavior, the driving forces of FF self-assembly must be understood. Molecular simulations have been utilized to assess these properties but have yielded conflicting conclusions due to inconsistencies in models chosen as well as the lack of quantitative analyses on the specific driving forces. Here, we present an all-atom explicit solvent molecular dynamics-based study on different length scales of FF aggregation. We utilize a free energy decomposition analysis as well as a dimer cluster analysis to identify the initial aggregation driving force to be FF intermolecular electrostatics, whereas solvent-mediated forces drive crystal growth. These data are consistent with the hypothesis that all hydrophobic dipeptides will have a similar initial aggregation mechanism until a critical aggregate size is reached, at which point crystallization occurs and subsequent crystal growth is dominated by solvent-mediated forces. We demonstrate that this proposed mechanism is testable by infrared spectroscopy focusing on the blueshift of the amide I peak as well as the ordering of the carboxylate peak.

Interested yet? Read on for other articles about 104-63-2, you can contact me at any time and look forward to more communication. Recommanded Product: 104-63-2.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 1243308-37-3, Name is Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride, molecular formula is , belongs to amides-buliding-blocks compound. In a document, author is Maini, Rumit, Quality Control of Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride.

By splicing the triazene structure with 1,3,4-thiadiazole and amide, fourteen unreported 1,3,4-thiadiazole triazene amide derivatives were synthesized. The structures of these compounds were characterized by nuclear magnetic resonance (NMR), infrared spectroscopy (IR) and high-resolution mass spectrometry (HRMS). By using the typical triazene drug dacarbazine as a reference, the activity detections of human esophageal cancer cells (EC109), human gastric cancer cells (MGC803) and human prostate cancer cells (PC-3) were carried out. The results showed that compounds 8a, 8h, 8i, 8k, and 8l had the best inhibitory activity against human prostate cancer cells (PC-3). And their IC50 values were 33.02, 34.05, 7.71, 4.82, 23.84 mu mol.L-1, which were far lower than the control drug their IC50 values were 33.02, 34.05, 7.71, 4.82, 23.84 mu mol.L-1, which were far lower than the control drug dacarbazine (146.43 mu mol.L-1).

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1243308-37-3, in my other articles. Quality Control of Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 1243308-37-3, Name is Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride, SMILES is O=C(OCC)C(NC1=NC=C(Cl)C=C1)=O.[H]Cl, belongs to amides-buliding-blocks compound. In a document, author is Purslow, Jeffrey A., introduce the new discover, Computed Properties of https://www.ambeed.com/products/1243308-37-3.html.

Supramolecular self-assembly is an excellent tool for controlling the optical and electronic properties of chromophore-based molecular systems. Herein, we demonstrate how differential self-assembly affects mechanoresponsive luminescence of fluorene-benzothiadiazole-based fluorophores. We have synthesized two donor-acceptor-donor- type conjugated oligomers consisting of fluorene as the donor and benzothiadiazole as the acceptor. For facile self-assembly, both molecules are end-functionalized with hydrogen-bonding amide groups. Differential self-assembly was induced by attaching alkyl chains of different lengths onto the fluorene moiety: hexyl (FB-C6) and dodecyl (FB-C12). The molecules self-assemble to form well-defined nanostructures in nonpolar solvents and solvent mixtures. Although their optical properties in solution are not affected by the alkyl chain length, significant effects were observed in the self-assembled state, particularly in the excitation energy migration properties. As a result, remarkable differences were observed in the mechanochromic luminescence properties of the molecules. A precise structure-property correlation is made using UV-visible absorption and fluorescence spectroscopy, time-correlated single-photon counting analysis, scanning electron microscopy, and X-ray diffraction spectroscopy.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1243308-37-3 is helpful to your research. Computed Properties of https://www.ambeed.com/products/1243308-37-3.html.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.2799-16-8, Name is (R)-1-Aminopropan-2-ol, SMILES is C[C@@H](O)CN, belongs to amides-buliding-blocks compound. In a document, author is Guan, Yan-Fang, introduce the new discover, HPLC of Formula: https://www.ambeed.com/products/2799-16-8.html.

The acylative kinetic resolution of racemic 2-methyl-1,2,3,4-tetrahydroquinoline and 3,4-dihydro-3-methyl-2H-[1,4]benzoxazines with acyl chlorides of N-naphthaloyl-(S)-alanine and N-naphthaloyl-(S)-phenylalanine has been studied. It has been shown that diastereoselective acylation of racemic amines with N-naphthaloyl (S)-amino acyl chlorides results in the predominant formation of (R,S)-amides, whereas acylation of the same amines with N-phthaloyl (S)-amino acyl chlorides proceeds with the opposite diastereoselectivity. The parallel kinetic resolution of racemic 3,4-dihydro-3-methyl-2H-[1,4]benzoxazine using a mixture of acylating agents derived from a single precursor, (S)-phenylalanine, was carried out.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2799-16-8 is helpful to your research. HPLC of Formula: https://www.ambeed.com/products/2799-16-8.html.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 1492-24-6, Name is H-Abu-OH, molecular formula is C4H9NO2. In an article, author is Shcherbina, L.,once mentioned of 1492-24-6, HPLC of Formula: https://www.ambeed.com/products/1492-24-6.html.

The ability of the 2-substituted aniline motif to serve as a scaffold for designing potential LuxR-regulated quorum sensing (QS) modulators has been investigated, using docking experiments and biological evaluation of a series of 15 specially synthesized compounds. Aniline, 2-acetyl-aniline and 2-nitroaniline were considered, as well as their N-acylated derivatives. Docking experiments showed that the 2-substituted aniline motif fits within the LuxR binding site at the place of the lactone moiety of AHL, and the biological evaluation revealed QS antagonisitic activity for several compounds, validating the hypothesis that this scaffold acts on QS. Structure activity relationships are discussed regarding interactions with the key residues of the LuxR binding site, showing significant variations in the H-bonding pattern.

Interested yet? Keep reading other articles of 1492-24-6, you can contact me at any time and look forward to more communication. HPLC of Formula: https://www.ambeed.com/products/1492-24-6.html.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics