Electric Literature of 57957-24-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 57957-24-1 as follows.
The compound 1a prepared in Example 2 was a boronized substrate, a different chiral ligand prepared in situ and Rh (nbd)2BF4As a catalyst, under different conditions, the preparation of chiral alpha-amino tertiary borate.The reaction is carried out by reacting alpha-arylalkenamide (1a) (0.3 mmol, 1.0 equiv), [Rh (nbd)2] BF4(0.006 mmol, 2 mol%), chiral ligands (0.006 mmol, 2 mol%), boronic acid pinacol ester (0.45 mmol, 1.5 equiv) and base (0.06 mmol, 0.2 equiv) were added to the dry reaction tube.Add solvent (1 mL).Followed by reaction at 60 C for 12 hours.The reaction was quenched with water (3 mL) and extracted with ethyl acetate (10 mL x 3).The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, concentrated and purified by column chromatography.The ee value of the reaction was determined by HPLC (OD-H or AD-H).
According to the analysis of related databases, 57957-24-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Organic Chemistry Institute; Tang Wenjun; Zhao Guoqing; Hu Naifu; (31 pag.)CN106146543; (2016); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics