Adding a certain compound to certain chemical reactions, such as: 141449-85-6, name is tert-Butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 141449-85-6, Product Details of 141449-85-6
A solution of (4-Chloro-5-methyl-3-trifluoromethylpyrazol-1-yl) acetic acid (97 mg), triethylamine (0.2 mL) and compound 5 (76 mg) in DMF (2 mL) was stirred at 0 C and 1-propanephosphonic acid cyclic anhydride (0.55 mL, 50% in EtOAc) was added dropwise. The reaction mixture was stirred another 30 min at 0 C and directly purified by preparative HPLC to provide the title compound 6 as a pale yellow oild (146 mg, 93%). LCMS: Rf: 4.495 min, M+H+ : 459.
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Reference:
Patent; CHEMOCENTRYX, INC.; WO2005/84667; (2005); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics