Application of 70-55-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 70-55-3 name is 4-Methylbenzenesulfonamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: In a round-bottom flask, a benzyl alcohol 2 (1.0 mmol), a sulfonamide1 (1.8 mmol) and BF3·OEt2 (151 muL, 1.2 mmol) were dissolved in CHCl3 (2.0 mL). The mixture was stirred for 2 h under reflux in air atmosphere, then the solvent was removed under reduced pressure using a rotary evaporator. The product was isolated by column chromatography of the residue on silica gel (EtOAc-PE, 1:10 to 1:2, v/v) to give the desired mono- and di-N-benzylated products 3 and 4.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Methylbenzenesulfonamide, and friends who are interested can also refer to it.
Reference:
Article; Pan, Jing; Li, Jia-Qiang; Huang, Ruo-Feng; Zhang, Xiao-Hui; Shen, Hang; Xiong, Yan; Zhu, Xiang-Ming; Synthesis; vol. 47; 8; (2015); p. 1101 – 1108;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics