Related Products of 621-38-5,Some common heterocyclic compound, 621-38-5, name is 3-Bromoacetanilide, molecular formula is C8H8BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The experimental alkylation procedure is similar to that as described in [18]. A screw top vial, under air, was charged with acetanilide substrate (1.0 mmol), [Cp*Co(CO)I2] (20 mol %, 0.20 mmol,95.2 mg), AgSbF6 (40 mol %, 0.4 mmol, 137.4 mg), NaOAc(40 mol %, 0.4 mmol, 16.4 mg), 3-buten-2-one (1.5 equiv,1.5 mmol, 105 mg) and 1,2-DCE (8.0 mL). The vial was sealed,and the reaction mixture heated to 80 C with stirring for 24 hours. After this period, the solvent was removed under reduced pressure and the crude product purified by column chromatography (ethyl acetate/petroleum ether; 80:20 in most cases). For full characterisation data of all products obtained, see Supporting Information File 1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromoacetanilide, its application will become more common.
Reference:
Article; Kenny, Andrew; Pisarello, Alba; Bird, Arron; Chirila, Paula G.; Hamilton, Alex; Whiteoak, Christopher J.; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 2366 – 2374;,
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