In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6331-71-1, name is 4-Amino-N,N-dimethylbenzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: amides-buliding-blocks
To a 500 ml three-mouth bottle by adding 200 ml of THF, cooling to 5 C the following add 17.3g (0.46mol, 4 . 0eq) of lithium aluminum hydride, then lower the temperature to the -5 C the following, the three aluminum chloride 3.0g (0.023mol, 0 . 2eq) THF slowly dropwise to the reaction in the solution, stirring for 10 min, temperature at 5 C the following starting to drop plus step amide 19.0g (0.114mol, 1 . 0eq) in 100 ml of solution THF. Added after stirring overnight TLC inspection reaction end, cooling to 0 C the following, starting the dropping water filtration, the filter cake is washed with dichloromethane eluviation, concentrated filtrate, vacuum distillation, to obtain colorless oily liquid 12.0g product. Yield: 71.0%, GC: 99.9%
The synthetic route of 6331-71-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shao Yuan Science and Technology (Shanghai) Co., Ltd.; Wu, Yong; Lei, Ting jun; Qi, Ming; (12 pag.)CN105461659; (2016); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics