Electric Literature of 17641-08-6,Some common heterocyclic compound, 17641-08-6, name is 2-Chloro-N-(3-methoxyphenyl)acetamide, molecular formula is C9H10ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The oxime 6 or 8 (0.7 mmol) and K2CO3(0.116 g, 0.84 mmol) were taken in dry DMF (5 mL), cooled to 0 Cand stirred for 30 min, then N-substituted acetamide (0.77 mmol)was added. The total reaction mixture was stirred at room temperature for 12-20 h. The reaction was monitored by TLC and after completion of the reaction, treated with ice cold water. Aqueous solution was extracted thrice with ethylacetate, combined extracts were washed with water till washings are neutral to pH, dried over anhydrous sodium sulfate and concentrated. The residue was purifiedby passing through a column packed with silica gel using petroleum ether/EtOAc (8:2) as eluent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-N-(3-methoxyphenyl)acetamide, its application will become more common.
Reference:
Article; Gannarapu, Malla Reddy; Vasamsetti, Sathish Babu; Punna, Nagender; Royya, Naresh Kumar; Pamulaparthy, Shanthan Rao; Nanubolu, Jagadeesh Babu; Kotamraju, Srigiridhar; Banda, Narsaiah; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 143 – 150;,
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