Month: August 2021

Synthetic Route of 207405-68-3, A common heterocyclic compound, 207405-68-3, name is tert-Butyl endo-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate, molecular formula is C12H22N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To the solution of compound 8 (0.23g, 1.2mmol) in THF (5mL) was added DIPEA (1.8mmol) and bicyclic amine or piperidin amine (1.44mmol). The reaction was stirred at r.t. for overnight. Then the mixture was diluted with ethyl acetate, washed with brine, dried over MgSO4, and evaporated. The residue was purified by column chromatography to give the product. 4.1.4 40 tert-butyl 4-((2-chloro-6, 7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)amino)piperidine-1-carboxylate (9)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Fang, Yuanying; Xiong, Lijuan; Hu, Jianguo; Zhang, Shaokun; Xie, Saisai; Tu, Liangxing; Wan, Yang; Jin, Yi; Li, Xiang; Hu, Shaojie; Yang, Zunhua; Bioorganic Chemistry; vol. 86; (2019); p. 103 – 111;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7150-72-3, name is tert-Butyl vinylcarbamate, A new synthetic method of this compound is introduced below., Application In Synthesis of tert-Butyl vinylcarbamate

In a Schlenck tube, tert-butyl N-ethenylcarbamate 7a (1.74 eq., 100 mg, 0.698 mmol) andtBuOK (1.91 eq., 86 mg, 0.766 mmol) were dissolved in DMSO (1 mL) under air atmosphereat 55 C. The mixture was stirred for 1 minute. Then 1,10-phenanthroline (2.6 eq., 188 mg, 1.05mmol) and ((thiophene-2-carbonyl)oxy)copper (1.29 eq., 99 mg, 0.519 mmol) were added. Theresulting mixture was stirred for another minute. Finally (2-bromoethynyl)benzene 8a (1 eq.,72.8 mg, 0.05 mL, 0.402 mmol) as a DMSO solution (1 mL) was added to the mixture. After10 minutes, the reaction was complete as judged by TLC (99:1, petroleum ether:ethyl acetate).The mixture was diluted with EtOAc, filtered over a pad of silica gel, washed with water andthen the organic layer was dried over MgSO4. After filtration, the solvent was removed undervacuum. The crude oil was purified by silica gel chromatography (100:0 to 95:5, petroleum ether:ethyl acetate) to give tert-butyl N-ethenyl-N-(2-phenylethynyl)carbamate 5a (69.5 mg,0.286 mmol, 74%) as slightly yellow oil.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Le Fouler, Vincent; Duret, Guillaume; Bisseret, Philippe; Blanchard, Nicolas; Tetrahedron Letters; vol. 59; 36; (2018); p. 3349 – 3352;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51-06-9, name is 4-Amino-N-(2-diethylaminoethyl)benzamide, A new synthetic method of this compound is introduced below., category: amides-buliding-blocks

Reactions were carried out by the oxidation of PAH by DPCfollowed under pseudo first order conditions where [PAH] [DPC] in both uncatalyzed and ruthenium(III) catalyzed(10 fold excess) reactions at room temperature. The kineticreactions and measurements were followed by our previouslab work.[5] UV-vis spectral changes observed during the oxidationreaction in the absence and presence of Ru(III) wasshown in (Figure S1). In the both cases the pseudo-first orderrate constants (kU and kC) were obtained from the plots oflog(Absorbance) versus time (Figure S1). The pseudo-firstorder plots were linear over three half-lives. The rate constants,kU and kC values are shown in Tables 1 and 2. As theFigure 1 shows that the spectral changes observed during bothuncatalyzed and catalyzed reactions at standard condition.From Figure 1 the concentration of DPC decreases slowly at415 nm. During the kinetics, a constant concentration viz.5.0105 mol dm3 of KIO4 was used throughout the study.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Meti, Manjunath D.; Nandibewoor, Sharanappa T.; Chimatadar, Shivamurti A.; Inorganic and Nano-Metal Chemistry; vol. 50; 4; (2020); p. 195 – 204;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 154350-29-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 154350-29-5 as follows.

To a solution of Boc-D-beta-vinyl cyclopropane amino acid (4.5g) in DMF was added CDI (3.97g). The reaction mixture was stirred at 4O0C for Ih and then added cyclopropylsulfonamide (4.66g) and DBU (5.78ml). The reaction mixture was stirred overnight at 4O0C. The reaction mixture was extracted with EtOAc. The organic extracts were washed with IM NaHCO3, brine, dried over Na2SO4, filtered and concentrated. The residue was desolved in 4NHCL/Dioxane. The reaction was stirred at RT for lhour and then concentrated in vacuo. The resulted solid was carrired out to next step without further purification. MS (ESI): m/z = 231.10 [M+H].

According to the analysis of related databases, 154350-29-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; WO2009/79352; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5900-59-4, name is 2-Amino-4-chlorobenzamide, A new synthetic method of this compound is introduced below., name: 2-Amino-4-chlorobenzamide

Reference example 2: 7-chloro-4(3H)-quinazolone 2-Amino-4-chlorobenzamide (25.6 g, 0.150 mol) obtained in Reference example 1 was dissolved in trimethyl orthoformate (560 ml), and to this added was concentrated hydrochloric acid (15 ml), and the mixture was stirred at room temperature for 1 hour. After completion of the reaction, the reaction solution was filtered, and the crude crystal filtered was suspended in water (250 ml) and neutralized with 3N NaOH aqueous solution. The neutralized solution was filtered, the solid being washed with water on the funnel to give 20.9 g (yield 77percent) of the title compound as white crystal.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Japan Energy Corporation; EP1229025; (2002); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2618-96-4, name is Dibenzenesulfonimide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C12H11NO4S2

General procedure: Under N2, ynamide 1a (0.300 mmol, 108.7 mg) and diphenylsulfonimide (2a; 0.600 mmol, 178.4 mg, 2.00 equiv) were dissolved in CH2Cl2 (4.00 mL). The reaction mixture was allowed to stir at r.t. After the consumption of 1a (4.5 h, TLC, eluent: PE-EtOAc, 4:1), the mixture was concentrated, and the residue was purified by flash chromatography on silica gel (eluent: PE-EtOAc, 6:1 ? 4:1) to afford 3a.

The synthetic route of 2618-96-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yu, Lian; Deng, Yuan; Cao, Jian; Synthesis; vol. 47; 6; (2015); p. 783 – 788;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 159326-71-3, name is Pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H5N3O

(Step 3) 4-chloropyrrolo[1,2-f][1,2,4]triazine; Diisopropylethylamine (3.5 mL, 20.3 mmol) was added to a solution of pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one (2.5 g, 18.5 mmol) dissolved in toluene (37.5 mL) under nitrogen atmosphere. Subsequently, after adding phosphorus oxychloride (5.1 mL, 55.7 mmol), the mixture was heated for 20 hours at 100 C. The resulting reaction mixture was cooled to 0 C. and, after slowly adding sodium bicarbonate aqueous solution, stirred at room temperature for 30 minutes. The resulting aqueous layer was extracted with ethyl acetate, dried with magnesium sulfate, and then filtered. The filtrate was concentrated in vacuum. The resulting yellow solid product was subjected to the next step without purification (2.31 g, 15.0 mmol, 81% yield).1H NMR (400 MHz, CDCl3): 8.22 (s, 1H), 7.87 (dd, J=2.4 Hz, 1.6 Hz, 1H), 7.00-6.97 (m, 2H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 159326-71-3.

Reference:
Patent; NEOPHARM CO., LTD.; US2011/183983; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 99733-18-3, name is tert-Butyl (7-aminoheptyl)carbamate, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 99733-18-3

General procedure: tert-butyl(3-aminopropyl)carbamate (3a,508 mg, 2.93 mmol)was added toa stirred solutionof4-aminobenzoic acid (2a, 200 mg, 1.46 mmol), EDCI (421mg, 2.20 mmol), HOBt(237 mg, 1.76 mmol), DIEA (502 muL, 2.92 mmol) in DMF (10 mL), stirred overnight at RT. After monitored by TLC to observe completion of reaction, the mixture was diluted with water (20 mL), and then the water phase was extracted with ethylacetate (20 mL×2). The combined organic phase was washed with water (20 mL×3)for three times and dried with anhydrous Na2SO4. The crude product was purified bysilica gel column chromatography to afford intermediates 5aa in 81% yield as whitesolid.

According to the analysis of related databases, 99733-18-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Wang, Xin; Yu, Chenhua; Wang, Cheng; Ma, Yakun; Wang, Tianqi; Li, Yao; Huang, Zhi; Zhou, Manqian; Sun, Peiqing; Zheng, Jianyu; Yang, Shengyong; Fan, Yan; Xiang, Rong; European Journal of Medicinal Chemistry; vol. 181; (2019);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

These common heterocyclic compound, 115643-59-9, name is 2-Amino-6-fluorobenzamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 115643-59-9

General procedure: To a solution of 5-hexynoic acid (3.0 mmol) in dryCH2Cl2 (5 mL) was added EDCI (3.1 mmol) and HOBt(3.1 mmol). The resulting mixture was stirred at rt for 2 h. Then substituted or unsubstituted 2-aminobenzamide (3.0 mmol) wasadded, and the reaction mixture was stirred at rt for 12 h whilebeing monitored by TLC. After the addition of H2O (10 mL) themixture was extracted with ethyl acetate (3 × 20 mL). Theorganic layers were combined and concentrated under vacuumto give the amide intermediate.

The synthetic route of 2-Amino-6-fluorobenzamide has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Hengshuai; Jiao, Shengchao; Chen, Kerong; Zhang, Xu; Zhao, Linxiang; Liu, Dan; Zhou, Yu; Liu, Hong; Beilstein Journal of Organic Chemistry; vol. 11; (2015); p. 416 – 424;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25900-61-2, name is 3-Amino-N-methylbenzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 25900-61-2

Step 2 To 2-chloro-4-(3-(4-fluorophenoxy)azetidin-l-yl)pyridine (90 mg, 0.323 mmol) and 3- amino-N-methylbenzamide (72.7 mg, 0.484 mmol) in 2-propanol (3.00 mL) in a disposable sealed tube at RT was added trifluoroacetic acid, (0.075 mL, 0.969 mmol). The resulting reaction mixture was heated at 84 C for 5 days and 92 C for 20 days, cooled to RT, concentrated, purified using MPLC (5 g cartridge, 12 g column, 0 to 100% 90/10 CH2CI2- MeOH in CH2CI2) giving 3-(4-(3-(4-fluorophenoxy)azetidin-l-yl)pyridin-2-ylamino)-N- methylbenzamide (73.6 mg).

The synthetic route of 25900-61-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMGEN INC.; BREGMAN, Howard; BUCHANAN, John, L.; CHAKKA, Nagasree; DIMAURO, Erin, F.; DU, Bingfan; NGUYEN, Hanh, Nho; ZHENG, Xiao, Mei; WO2011/103196; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics