Month: August 2021

Related Products of 683-57-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 683-57-8, name is 2-Bromoacetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 4-chloro-5H-pyrrolo [3, 2-d]pyrimidine (1.54 g, 10.0 iranol) , 2-bromoacetamide (1.51 g, 10.9 mmol) , cesium carbonate (3.58 g, 11.0 mmol) and N,N-dimethylformamide (13 mL) was stirred at room temperature for 69 hr. Cesium carbonate (1.30 g, 3.99 mmol) was added, and the reaction mixture was stirred at room temperature for 24 hr. The reaction mixture was diluted with water, and extracted with ethyl acetate (chi7) . The organic layers were combined, dried over anhydrous magnesium sulfate, and filtrated. The filtrate was concentrated under reduced pressure to give the title compound (1.81 g, 86%) as a yellow solid.1H-NMR (DMSOd6, 300 MHz) delta 5.14 (2H, s) , 6.73 (IH, d, J = 3.3 Hz), 7.30 (IH, br s) 7.68 (IH, br s) , 7.95 (IH, d, J = 3.3 Hz) , 8.61 (IH, s) .

The synthetic route of 2-Bromoacetamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2007/4749; (2007); A1;,
Amide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 147291-66-5, name is tert-Butyl 3-aminobenzylcarbamate, A new synthetic method of this compound is introduced below., COA of Formula: C12H18N2O2

tert-butyl (3-amino-benzyl)-carbamate 9.35 g (76.49 mmol) 3-aminomethyl-phenylamine are dissolved in 200 ml dichloromethane and 100 ml of tetrahydrofuran, a solution of 17.03 g (78.02 mmol) Boc-anhydride in 200 ml dichloromethane is added dropwise. The mixture is stirred for 2.5 hours at ambient temperature, then evaporated down. The residue is precipitated as the hydrochloride. Yield: 17.48 g (88% of theoretical)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Brandl, Trixi; Maier, Udo; Hoenke, Christoph; Joergensen, Anne T.; Pautsch, Alexander; Breitfelder, Steffen; Grauert, Matthias; Hoffmann, Matthias; Scheuerer, Stefan; Erb, Klaus; Pieper, Michael; Pragst, Ingo; US2007/238746; (2007); A1;,
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Amide – an overview | ScienceDirect Topics

Application of 2736-23-4,Some common heterocyclic compound, 2736-23-4, name is 2,4-Dichloro-5-sulfamoylbenzoic acid, molecular formula is C7H5Cl2NO4S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The mixture of appropriate 2,4-dichloro-5-sulfamoylbenzoic acid (compound 1) or 2,4- dibromo-5-sulfamoylbenzoic acid (compound 2) (10.0 mmol), SOQ2 (2-3 eq), and 1 drop DMF in toluene (5 ml) was refluxed for 4 h. Excess SOCb and toluene were removed by distillation under reduced pressure, and the crude acid chloride was used directly in the next step.

The synthetic route of 2736-23-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VILNIUS UNIVERSITY; MATULIS, Daumantas; ?APKAUSKAIT?, Edita; ZAK?AUSKAS, Andrius; MORK?NAIT?, Vaida; (82 pag.)WO2017/17505; (2017); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 6292-59-7, name is 4-(tert-Butyl)benzenesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6292-59-7, Product Details of 6292-59-7

Process for conversion of compound (2) to (3) (stage 2)A mixture of DMSO (10 vol), potassium carbonate (1.2 eq), 4-tert-butyl phenyl sulfonamide (1 eq) and compound (2) (1 eq) was heated at 1200C for 10 hours. After completion of the reaction, water (25 vol) was added to the reaction mixture, the reaction mixture was acidified with a solution of tartaric acid (1.8 eq) in water (25 vol) to pH 3, and the precipitated solid was filtered under vacuum and dried under vacuum (lOmbar) at 500C for 2 hours. The product (compound (3)) was obtained as a light brown solid (molar yield = 100percent).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; GENERICS [UK] LIMITED; MYLAN INDIA PRIVATE LIMITED; WO2009/98517; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

195986-74-4, name is 7-Bromo-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C9H7BrN2O2

To a solution of 7-bromo-3,4~dihydro-lH-benzo[e][l,4]diazepine-2,5-dione (1 equiv) in dry dioxan (0.1 M) were added bis(pinacolato)diboron (1.1 equiv), potassium acetate (3.5 equiv) and dppf (0.05 equiv). The reaction mixture was degassed with nitrogen for 20 minutes. PdCl2(dppf) (0.05 equiv) was added to the reaction mixture, which was degassed for a further 5 minutes. The reaction was heated to 120 C for 16 hours under nitrogen. The reaction mixture was partitioned between CH2CVMeOH and water. The aqueous phase was further extracted with CH2Cl2MeOH. The combined organic phases were dried (MgSO4), filtered and concentrated in vacuo. The residue was sonicated in hexane/ CH2Cl2, filtered, sonicated in CH2Cl2 and filtered to yield the desired product.7-(4,4,5,5-Tetramethyl-[l,3,2]dioxaborolan-2-yl)-3,4-dihydro-lH-benzo[e][l,4]diazepine-2,5- dione: (63 % yield, 85 % purity main impurity being the boronic acid 15 %) m/z (LC-MS, ESP): 303.4 [M+H]+ R/T = 3.08 min

The synthetic route of 195986-74-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KUDOS PHARMACEUTICALS LIMITED; WO2008/23161; (2008); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

These common heterocyclic compound, 120157-97-3, name is N-Boc-2-(4-Bromophenyl)ethylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of N-Boc-2-(4-Bromophenyl)ethylamine

A mixture of N-boc-2-(4-bromophenyl)ethylamine, the desiredarylboronic acid (a-m) (1.2 equiv), tetrakis(triphenylphosphine)-palladium(0) (0.04 equiv), Na2CO3 (5 equiv) in degassed toluene/H2O (5/2) was refluxed for 18 h. The reaction mixture was filteredthrough Celite and concentrated in vacuo. The resulting residuewas dissolved in in EtOAc (200 mL), washed with H2O (200 mL 2) and brine (200 mL). The organic layer was dried with anhydrousNa2SO4 and concentrated in vacuo. The residue was purified by columnchromatography on SiO2. Using Method E, 13 (1.00?g, 3.3?mmol), 4-methoxyphenylboronic acid (0.61?g, 4.0?mmol), tetrakis(triphenylphosphine)palladium(0) (0.15?g, 0.1?mmol), Na2CO3 (1.77?g, 16.7?mmol) in toluene/H2O (33?ml/13.3?ml), followed by 4.0?M HCl in dioxane (2.50?ml, 10.0?mmol) gave 14j as a white solid (0.52?g, 58%): Rf?=?0.00 (EtOAc 9: acetone 1): 1H NMR (DMSO-d6, 400?MHz) delta 3.02-3.05 (m, NH3CH2CH2), 3.82 (OCH3), 6.93 (d, J?=?8.1?Hz, 1 ArH), 7.18-7.23 (m, 2 ArH), 7.35-7.40 (m, 3 ArH), 7.64 (d, J?=?6.8?Hz, 2 ArH), 8.37 (s, NH3); 13C NMR (DMSO-d6, 75?MHz) delta 33.0 (NCH2CH2), 55.6 (CH3), 112.5, 113.4, 119.3, 127.4, 129.7, 130.4, 137.4, 138.9, 141.9, 160.2 (12 ArC).

The synthetic route of N-Boc-2-(4-Bromophenyl)ethylamine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yeon, Seul Ki; Choi, Ji Won; Park, Jong-Hyun; Lee, Ye Rim; Kim, Hyeon Jeong; Shin, Su Jeong; Jang, Bo Ko; Kim, Siwon; Bahn, Yong-Sun; Han, Gyoonhee; Lee, Yong Sup; Pae, Ae Nim; Park, Ki Duk; Bioorganic and Medicinal Chemistry; vol. 26; 1; (2018); p. 232 – 244;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 39945-54-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39945-54-5, name is Benzyl (3-bromopropyl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 7 3-[4-(2-Methoxyphenyl)piperazin-1-yl]propylamine The following is the preparation of a compound of Formula 3 in which R1 is methoxy, R2 is hydro and R9 is amino. A mixture of benzyl (3-bromopropyl)aminoformate (495.2 g, 1.82 mol), prepared as in Example 6, 1-(2-methoxyphenyl)piperazine hydrochloride (377.9 g, 1.65 mol) and potassium carbonate (456.8 g, 3.31 mol) in 3L of DMF was stirred at 80 to 81 C. for 3.5 hours. The mixture was allowed to cool to room temperature and then poured into 20L of water. The mixture was extracted with ethyl acetate (3*4L). The combined ethyl acetate extracts were washed with water (2*1L) and saturated aqueous sodium chloride (1*1L), dried (Na2 SO4) and treated with silica gel (200 g). The ethyl acetate was filtered and 11L of the filtrate was added slowly to 200 mL of 5.5N hydrochloric acid (2.75 mol) in ethanol at a rate such that the reaction temperature did not exceed 23 C. The mixture was aged at room temperature for 1 hour and filtered. The filtered residue was washed with ethyl acetate (3*500 mL), dried under a stream of air for 17 hours and then dried under reduced pressure at 60 C. to give benzyl 3-[4-(2-methoxyphenyl)piperazin-1-yl]propylaminoformate dihydrochloride (496 g, 1.09 mol), m.p. 174-176 C.

The synthetic route of Benzyl (3-bromopropyl)carbamate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Syntex (U.S.A.) Inc.; US5688795; (1997); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2603-10-3, name is Methyl N-Phenylcarbamate, A new synthetic method of this compound is introduced below., Quality Control of Methyl N-Phenylcarbamate

Aniline 4650 g, dimethyl carbonate 226.7 g,Zinc acetate 3.65 g in turn into the reactor,After replacing with nitrogen and pressurized to 0.2 Mpa, heated to 180 C,Reaction at this temperature for 5 h.After completion of the reaction, the temperature of the reactor was reduced to 80 C and constant temperature,To the autoclave, add 40 mL of concentrated hydrochloric acid,A constant-flow pump was added dropwise with an aqueous formaldehyde solution (40% by mass) at a dropping rate of 0.15 mL / min,The dropping time is 100 min. After completion of the dropwise addition, the reaction was continued at 80 C for 2 h.After completion of the reaction, the reaction solution was analyzed by high performance liquid chromatography,The yield of methyl 4,4′-diphenylmethane dicarbamate was 67%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Research Institute of Nanjing Chemical Industry Group; ina Petroleum & Chemical Corporation; JIN, YUCUN; JIN H, ANQIANG; WU, QIJIAN; CHEN, YONGPING; LIU, ZHUO; HE, YUMIAO; (4 pag.)CN106543038; (2017); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 97-35-8, name is 3-Amino-N,N-diethyl-4-methoxybenzenesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 97-35-8, Product Details of 97-35-8

EXAMPLE 12 Synthesis of 2-hydroxy-3,6-bis(2-methoxy-5-diethylaminosulfonyl-aminocarbonyl)naphthalene STR22 3-Amino-4-methoxydiethylaminosulfonylbenzene (15.6 g), N-methyl-2-pyrrolidone (86.1 g) and toluene (34.3 g) were dissolved at room temperature and the acid chloride (5.4 g) obtained in Example 6 was gradually added, and then the mixture was amidated at 90 C. for 24 hours. After the reaction solution was cooled to 25 C. and filtered, toluene was distilled off under reduced pressure. Then, the solution was crystallized by using methanol (350.1 g). The resultant product was filtered and then dried to obtain 8.9 g of 2-hydroxy-3,6-bis(2-methoxy-5-diethylaminosulfonylphenyl-aminocarbonyl)naphthalene as a cream powdered crystal (DSC analysis value: 245.0 C.). An infrared spectrum (KBr method) of this compound is shown in FIG. 12.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo; US5786523; (1998); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 830-43-3, name is 4-(Trifluoromethyl)benzenesulfonamide, A new synthetic method of this compound is introduced below., Quality Control of 4-(Trifluoromethyl)benzenesulfonamide

General procedure: All solid chemicals used were dried in vacuum over P2O5 overnight.The acid derivative and CDI were dissolved in dry THF underN2 atmosphere and the mixture was allowed to stir at 66-68 C for2 h. The sulfonamide and DBU dissolved in THF were added to thereaction mixture and stirring was continued at room temperature(4 h-overnight).Method B1: The solvent was removed in vacuo, water was addedand pH was adjusted to 2 by addition of 1 M HCl aq. The aqueousphase was extracted with EtOAc (2 40 ml), dried with MgSO4, filteredand evaporated in vacuo. For most of the compounds, a silicagel column was first run, followed by purification on aluminumoxide.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Belfrage, Anna Karin; Abdurakhmanov, Eldar; Akerblom, Eva; Brandt, Peter; Oshalim, Anna; Gising, Johan; Skogh, Anna; Neyts, Johan; Danielson, U. Helena; Sandstroem, Anja; Bioorganic and Medicinal Chemistry; vol. 24; 12; (2016); p. 2603 – 2620;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics