Month: August 2021

Application of 147291-66-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 147291-66-5, name is tert-Butyl 3-aminobenzylcarbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A solution of 4-chloro-7,8-dimethoxy-1- [1,2,4] triazolo [4,3-a] quinolizinaminophenyl- [ 4] triazolo [4,3-a] quinoxaline (2 g, 7.18 mmol)And diisopropylethylamine (DIPEA, 2.5 ml, 14.4 mmol),tert-Butyl (3-aminobenzyl) carbamate (2.75 ml, 14.4 mmol) was refluxed with 20 ml of isopropyl alcohol for 18 hours. After completion of the reaction, the reaction mixture was cooled to room temperature, and the resulting solid was filtered and dried under reduced pressure to obtain 2.6 g of the target compound

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 3-aminobenzylcarbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Korea Research Institute of Chemical Technology; Lee Gwang-ho; Choi Gil-don; Al Ri-im-ran; (56 pag.)KR2018/106597; (2018); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 621-38-5,Some common heterocyclic compound, 621-38-5, name is 3-Bromoacetanilide, molecular formula is C8H8BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The experimental alkylation procedure is similar to that as described in [18]. A screw top vial, under air, was charged with acetanilide substrate (1.0 mmol), [Cp*Co(CO)I2] (20 mol %, 0.20 mmol,95.2 mg), AgSbF6 (40 mol %, 0.4 mmol, 137.4 mg), NaOAc(40 mol %, 0.4 mmol, 16.4 mg), 3-buten-2-one (1.5 equiv,1.5 mmol, 105 mg) and 1,2-DCE (8.0 mL). The vial was sealed,and the reaction mixture heated to 80 C with stirring for 24 hours. After this period, the solvent was removed under reduced pressure and the crude product purified by column chromatography (ethyl acetate/petroleum ether; 80:20 in most cases). For full characterisation data of all products obtained, see Supporting Information File 1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromoacetanilide, its application will become more common.

Reference:
Article; Kenny, Andrew; Pisarello, Alba; Bird, Arron; Chirila, Paula G.; Hamilton, Alex; Whiteoak, Christopher J.; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 2366 – 2374;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 25823-52-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25823-52-3 as follows.

A mixture of the compound of formula (De), 6,7-dihydro-2H- benzo[6,7]cyclohepta[1 ,2-c]pyridazin-3(5H)-one (4.0 g, 19.3 mmol) and POCI3 (20 ml_) was refluxed for 2 h. After cooling to ambient temperature, the volatiles were evaporated. The residue was poured into a mixture of ice water and sodium bicarbonate, CH2CI2 (200 ml_) was added to dissolve the solid. The layers were separated, and the aqueous layer was extracted with CH2CI2 one more time. The combined organic layers were washed with brine. After being dried (MgSO4), filtered, and concentrated, the compound of formula (Df), 3-chloro-6,7-dihydro-5H- benzo[6,7]cyclohepta[1 ,2-c]pyridazine was obtained as a yellow solid (4.3 g, 99%), 1H NMR (300 MHz, CDCI3) delta: 7.82 (m, 1H), 7.45-7.24 (m, 4H), 2.59-2.51 (m, 4H), 2.27 (quant, J = 6.9 Hz, 2H); LC-MS: purity: 100%; MS (m/e): 231 (MH+).

According to the analysis of related databases, 25823-52-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; RIGEL PHARMACEUTICALS, INC.; SINGH, Rajinder; HECKRODT, Thilo, J.; HOLLAND, Sacha; WO2010/5876; (2010); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 141449-85-6, A common heterocyclic compound, 141449-85-6, name is tert-Butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate, molecular formula is C11H20N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of compound (17b) (100 mg, 0.27 mmol), tert-butyl Hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylate (86 mg, 0.40 mmol) and DIPEA (187 muL, 1.08 mmol) in 2 mL of DMSO (2 mL) was stirred for 2 days at 80C. The reaction mixture was concentrated under reduced pressure. The residue was triturated with diethyl ether to afford compound (24a) as a yellow solid (139 mg, 0.25 mmol, 94%). MS m/z ([M+H]+) 548.

The synthetic route of 141449-85-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LABORATOIRE BIODIM; Atamanyuk, Dmytro; Chevreuil, Francis; Faivre, Fabien; Lecointe, Nicolas; Ledoussal, Benoit; Oliveira, Chrystelle; Simon, Christophe; EP2913330; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

These common heterocyclic compound, 317595-54-3, name is tert-Butyl (2-aminocyclohexyl)carbamate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of tert-Butyl (2-aminocyclohexyl)carbamate

Step 1 cis-N-tert-Butoxycarbonyl-2-(2-ethoxycarbonyl-6-methoxyquinazolin-4-yl)aminocyclohexylamine A solution of 1.96 g of 4-chloro-2-ethoxycarbonyl-6-methoxyquinazoline in 70 mL of toluene was combined with 1.58 g of cis-2-tert-butoxycarbonylaminocyclohexylamine and 0.74 g of triethylamine, and heated under reflux for 15 hours. After concentrating, the mixture was combined with water, extracted with chloroform, and dried. After the solvent was distilled off, the residue was purified by column chromatography on silica gel (chloroform) to obtain 2.70 g of the desirable compound.

The synthetic route of tert-Butyl (2-aminocyclohexyl)carbamate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Okano, Masahiko; Mori, Kazuya; US2003/119855; (2003); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 123986-64-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 123986-64-1, name is tert-Butyl 4-(hydroxymethyl)benzylcarbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(4-Hydroxymethyl~benzyl)-carbamic acid tert-butyl ester (480 mg, 0.71 mmol) was dissolved in DCM (3 ml_) and cooled to -78 0C (dry ice / acetone). Dess-Martin periodinane (331 mg, 0.78 mmol) was added to the reaction which was allowed to warm to r.t and stir for 3 h. A 1 :1 solution of saturated sodium bicarbonate and sodium sulfite (20 ml_) was added and the reaction mixture stirred vigorously for 15 min. The organic layer was isolated, washed with saturated sodium bicarbonate (10 ml_), dried (Na2SO4) and evaporated to dryness to afford the desired compound (480 mg, 100%). m/z 258 [M++Na]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 4-(hydroxymethyl)benzylcarbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CHROMA THERAPEUTICS LTD; WO2006/117549; (2006); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 53844-02-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53844-02-3, name is Benzyl (2-bromoethyl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a solution of benzyl(2-bromoethyl)carbamate 9 (129 mg, 0.5 mmol) and the corresponding Michael acceptor 11 (0.5 mmol) in THF (2.5 mL) at 0 C, was added NaH (60% in mineral oil, 24 mg, 0.6 mmol) portion by portion. The ice bath was removed and the reaction mixture was stirred for 3 h to 3 days (monitored by TLC), was then poured into a saturated NH4Cl solution, and extracted with ethyl acetate (2 25 mL). The organic phase was washed with brine, dried over MgSO4, filtered, and concentrated in vacuo. The crude mixture was purified by flash chromatography (cyclohexane/EtOAc: 20/ 80).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Benzyl (2-bromoethyl)carbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Goermen, Meral; Le Goff, Ronan; Lawson, Ata Martin; Daich, Adam; Comesse, Sebastien; Tetrahedron Letters; vol. 54; 17; (2013); p. 2174 – 2176;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 37073-15-7, name is 1-(Methylsulfonyl)-1H-benzo[d][1,2,3]triazole, molecular formula is C7H7N3O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H7N3O2S

Example 1 (E)-1-(benzotriazol-1-yl)-3-phenyl-2-propen-1-one 1.42 g (0.01 mol) of trans-cinnamic acid (compound of formula IV) and 1.97 g (0.01 mol) of 1-(methylsulfonyl)benzotriazole are stirred at room temperature in 50 ml of tetrahydrofuran, followed by dropwise addition of 0.014 mol of triethylamine. The solution is then refluxed for 24 hours, and then evaporated under reduced pressure. The residue is taken up in 60 ml of water and extracted with 70 ml of ethyl acetate. The organic phase is dried, filtered and then concentrated under vacuum. The powder obtained is taken up in 50 ml of acetonitrile and filtered off by suction. 2.24 g of a white powder are obtained. Melting point: 157 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 37073-15-7, its application will become more common.

Reference:
Patent; PRODUITS CHIMIQUES AUXILIAIRES ET DE SYNTHESE; Rault, Sylvain; Lancelot, Jean Charles; Suzanne, Peggy; Voisin-Chiret, Anne-Sophie; Pecquet, Regis; Joseph, Jean-Christophe; US2013/165507; (2013); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 94838-59-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 94838-59-2 as follows.

A mixture of 2-(3-bromopropoxy)tetrahydro-2//-pyran (669mg,3 mmol), tert- butyl 4- aminophenethylcarbamate (709 mg, 3 mmol) and cesium carbonate (2.9 g, 9 mmol) in DMF (20 mL) was stirred at 110 C for 2 h. TLC showed the reaction completed. The reaction mixture was filtered. The filtrate was concentrated and purified by column chromatography to afford the title compound as yellow oil (l80mg, 15.9% yield). NMR (500 MHz, DMSO-r/6) S: 6.94 (d, J= 8.3 Hz, 2H), 6.84 (t, J= 5.4 Hz, 1H), 6.54 (d, J= 8.4 Hz, 2H), 5.42 (t, J= 5.6 Hz, 1H), 4.61 (t, J= 3.4 Hz, 1H), 3.79 (tt, J= 12.6, 4.8 Hz, 2H), 3.49 (dt, J= 9.4, 6.2 Hz, 2H), 3.16 – 3.02 (m, 4H), 2.58 (d, J= 8.0 Hz, 2H), 1.87 – 1.64 (m, 4H), 1.57 – 1.47 (m, 4H), 1.41 (d, J= 15.5 Hz, 9H).

According to the analysis of related databases, 94838-59-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ZHEJIANG VIMGREEN PHARMACEUTICALS, LTD; SUN, Sanxing; ZHAO, Long; HU, Chongbo; CHEN, Zhengshu; YE, Jinqi; (0 pag.)WO2020/2969; (2020); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 125414-41-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 125414-41-7, name is tert-Butyl (1,3-dihydroxypropan-2-yl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

tert-Butyl (l,3-dihydroxypropan-2-yl)carbamate (3.7 g, 19.35 mmol), potassium hydroxide (4.0 g, 71.59 mmol), and benzyl bromide (12.24 g, 71.59 mmol) were dissolved in 50 mL of DMF. The mixture was stirred for 2 h and concentrated under vacuum. The crude product was purified using column chromatography to yield tert-butyl (1 ,3-bis(benzyloxy)propan-2- yl)carbamate (3.25 g, 45% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (1,3-dihydroxypropan-2-yl)carbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NEKTAR THERAPEUTICS (INDIA) PVT.LTD.; NEKTAR THERAPEUTICS (Incorporated under the Laws of Delaware and domiclled in the State of California); DUARTE, FRANCO; ANAND, NEEL; SHARMA, PANKAJ; SINGH, DEVENDRAPRATAP U.; WO2015/79459; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics