In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 758-96-3, name is N,N-Dimethylpropionamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C5H11NO
General procedure: To a stirred solution of 46 (800 mg, 2.71 mmol) in THF (20 mL) was slowly added n-BuLi (1.58 mol/L in n-hexane; 3.90 mL, 6.16 mmol) at -78 C under an argon atmosphere. After stirring for 1 h at the same temperature, N,N-dimethylpropionamide (0.890 mL, 8.10 mmol) was added in one portion at -78 C and the reaction mixture was allowed to gradually warm to room temperature over 3 h. The reaction was quenched with satd NH4Cl aq and the resulting mixture was extracted with EtOAc. The organic layer was washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (CHCl3) to give 47 (342 mg, 1.26 mmol, 46%) as a white solid.
The synthetic route of 758-96-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ochiai, Koji; Takita, Satoshi; Eiraku, Tomohiko; Kojima, Akihiko; Iwase, Kazuhiko; Kishi, Tetsuya; Fukuchi, Kazunori; Yasue, Tokutaro; Adams, David R.; Allcock, Robert W.; Jiang, Zhong; Kohno, Yasushi; Bioorganic and Medicinal Chemistry; vol. 20; 5; (2012); p. 1644 – 1658;,
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