I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article C-N Coupling of DNA-Conjugated (Hetero)aryl Bromides and Chlorides for DNA-Encoded Chemical Library Synthesis published in 2020. Product Details of 104-10-9, Reprint Addresses Chen, YC; Simmons, N (corresponding author), Baylor Coll Med, Ctr Drug Discovery, Dept Pathol & Immunol, Houston, TX 77030 USA.. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol
DNA-encoded chemical library (DECL) screens are a rapid and economical tool to identify chemical starting points for drug discovery. As a robust transformation for drug discovery, palladium-catalyzed C-N coupling is a valuable synthetic method for the construction of DECL chemical matter; however, currently disclosed methods have only been demonstrated on DNA-attached (hetero)aromatic iodide and bromide electrophiles. We developed conditions utilizing an N-heterocyclic carbene-palladium catalyst that extends this reaction to the coupling of DNA-conjugated (hetero)aromatic chlorides with (hetero)aromatic and select aliphatic amine nucleophiles. In addition, we evaluated steric and electronic effects within this catalyst series, carried out a large substrate scope study on two representative (hetero)aryl bromides, and applied this newly developed method within the construction of a 63 million-membered DECL.
Product Details of 104-10-9. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Chen, YC; Faver, JC; Ku, AF; Miklossy, G; Riehle, K; Bohren, KM; Ucisik, MN; Matzuk, MM; Yu, ZF; Simmons, N or concate me.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics