Month: October 2021

An article Scandium-catalyzed Michael addition of quinazolinones and vinylazaarenes WOS:000535721300001 published article about ALLYLIC SUBSTITUTION; FUNCTIONALIZATION; HYDROAMINATION; HETEROCYCLES; 2-PYRIDONES; ALKYLATION; DISCOVERY in [Zhang, Zhiguang; Dai, Siwei; Li, Ling; Jia, Chenyu; Zhang, Yong] Hebei Univ Sci & Technol, Coll Chem & Pharmaceut Engn, 26 Yuxiang Rd, Shijiazhuang 050018, Hebei, Peoples R China; [Li, Hao] East China Univ Sci & Technol, State Key Lab Bioengn Reactor, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China; [Li, Hao] East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China in 2020, Cited 35. Computed Properties of C7H5N3O. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4

We described a novel scandium-catalyzed selective Michael addition of quinazolinones and vinylazaarenes. The protocol proceeds smoothly to give diverse quinazolinone derivatives in moderate to excellent yields. The high practicality of this protocol was proved by excellent chemo selectivity and broad substrate and functional group compatibility. (C) 2020 Elsevier Ltd. All rights reserved.

Computed Properties of C7H5N3O. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Zhang, ZG; Dai, SW; Li, L; Jia, CY; Zhang, Y; Li, H or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Formula: C13H13N. Biosca, M; Salto, J; Magre, M; Norrby, PO; Pamies, O; Dieguez, M in [Biosca, Maria; Salto, Joan; Magre, Marc; Pamies, Oscar; Dieguez, Montserrat] Univ Rovira & Virgili, Dept Quim Fis & Inorgan, C Marcel Li Domingo 1, E-43007 Tarragona, Spain; [Norrby, Per-Ola] AstraZeneca Gothenburg, R&D BioPharmaceut, Pharmaceut Sci, Data Sci & Modelling, Pepparedsleden 1, S-43150 Molndal, Sweden; [Norrby, Per-Ola] Univ Gothenburg, Dept Chem & Mol Biol, Kemigarden 4, S-41296 Gothenburg, Sweden published An Improved Class of Phosphite-Oxazoline Ligands for Pd-Catalyzed Allylic Substitution Reactions in 2019.0, Cited 129.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A method for generation of Pd/phosphite-oxazoline catalysts containing an alkyl backbone chain has been successfully applied to Pd-catalyzed allylic substitution reactions. By carefully selecting the substituents at both the alkyl backbone chain and the oxazoline of the ligand, as well as the configuration of the biaryl phosphite group, high activities (TOF > 8000 mol substrate X (mol Pd X h)(-1)) and excellent enantioselectivities (ee’s up to 99%) have been achieved for many hindered and unhindered substrates with a wide range of C-, O-, and N-nucleophiles (73 substitution products in total). Moreover, DFT and NMR studies of the key Pd-allyl complexes allowed us to better understand the origin of the excellent enantioselectivities observed experimentally. The useful application of the Pd/phosphite-oxazoline catalysts was demonstrated by the syntheses of many chiral carbobicycles, with multiples stereocenters, by simple sequential reactions involving Pd-allylic substitution and either 1,6-enyne cyclization or Pauson-Khand enyne cyclization.

Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Biosca, M; Salto, J; Magre, M; Norrby, PO; Pamies, O; Dieguez, M or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article NaNO2/I-2 as an alternative reagent for the synthesis of 1,2,3-benzotriazin-4(3H)-ones from 2-aminobenzamides WOS:000456353000009 published article about CATALYZED DENITROGENATIVE ANNULATION; TERT-BUTYL NITRITE; NEMATOCIDAL ACTIVITIES; SELECTIVE SYNTHESIS; DERIVATIVES; 1,2,3-BENZOTRIAZINE-4-(3H)-ONES; ACID in [Barak, Dinesh S.; Mukhopadhyay, Sushobhan; Dahatonde, Dipak J.; Batra, Sanjay] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Sect 10,Jankipuram Extens,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India; [Batra, Sanjay] CSIR HRDC, Postal Staff Coll Area, Sect 19, Ghaziabad 201002, India in 2019, Cited 39. Name: Benzo[d][1,2,3]triazin-4(3H)-one. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4

An efficient transformation of 2-aminobenzamides to 1,2,3-benzotriazin-4(3H)-ones in the presence of sodium nitrite (NaNO2) and Iodine (I-2) is described. The reaction is proposed to proceed via formation of nitrosyl halide that induces nitrosylation of the amino group of 2-aminobenzamide leading to diazotization followed by intramolecular cyclization. (C) 2018 Elsevier Ltd. All rights reserved.

Name: Benzo[d][1,2,3]triazin-4(3H)-one. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Barak, DS; Mukhopadhyay, S; Dahatonde, DJ; Batra, S or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, XL; Zhou, Z; Li, Z; Xu, XY in [Chen, Xiulei; Zhou, Zhen; Li, Zhong; Xu, Xiaoyong] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China; [Li, Zhong; Xu, Xiaoyong] Shanghai Collaborat Innovat Ctr Biomfg Technol, Shanghai, Peoples R China published Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita in 2020, Cited 29. Computed Properties of C7H5N3O. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4.

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol were synthesized and characterized by H-1 NMR, C-13 NMR, F-19 NMR and HRMS. The bioassay results showed that compounds 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-7-methoxybenzo[d][1-3]triazin-4(3H)-one, 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-6-nitrobenzo[d][1-3]triazin-4(3H)-one, 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1-3]triazin-4(3H)-one exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L-1 in vivo. Compound 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1-3]triazin-4(3H)-one showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L-1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further.

Computed Properties of C7H5N3O. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Chen, XL; Zhou, Z; Li, Z; Xu, XY or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocks. Recently I am researching about CARBONYL-COMPOUNDS; DEOXYGENATION; ALCOHOLS; HYDROGENOLYSIS; 1,2-DIOLS; AMINES; HYDROSILYLATION; ACTIVATION; CONVERSION; MECHANISM, Saw an article supported by the Alexander von Humboldt FoundationAlexander von Humboldt Foundation. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Fang, HQ; Oestreich, M. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

The strong boron Lewis acid tris(pentafluorophenyl)borane B(C6F5)(3) is known to catalyze the dehydrogenative coupling of certain amines and hydrosilanes at elevated temperatures. At higher temperature, the dehydrogenation pathway competes with cleavage of the C-N bond and defunctionalization is obtained. This can be turned into a useful methodology for the transition-metal-free reductive deamination of a broad range of amines as well as heterocumulenes such as an isocyanate and an isothiocyanate.

About Diphenylmethanamine, If you have any questions, you can contact Fang, HQ; Oestreich, M or concate me.. Category: amides-buliding-blocks

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocks. Chen, X; Yang, X; Mao, F; Wei, JL; Xu, YX; Li, BL; Zhu, J; Ni, SS; Jia, LJ; Li, J in [Chen, Xin; Mao, Fei; Wei, Jinlian; Xu, Yixiang; Li, Baoli; Zhu, Jin; Li, Jian] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab New Drug Design, 130 Mei Long Rd, Shanghai 200237, Peoples R China; [Yang, Xi; Ni, Shuaishuai; Jia, Lijun] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Canc Inst, Shanghai 200032, Peoples R China; [Li, Jian] Dali Univ, Coll Pharm & Chem, 5 Xue Ren Rd, Dali 671000, Yunnan, Peoples R China; [Li, Jian] East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, 130 Mei Long Rd, Shanghai 200237, Peoples R China published Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth in vitro and in vivo in 2021.0, Cited 41.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Ubiquitin-like protein neddylation is overactivated in various human cancers and correlates with disease progression, and targeting this pathway represents a valuable therapeutic strategy. Our previous work disclosed an antihypertensive agent, candesartan cilexetic (CDC), serves as a novel neddylation inhibitor for suppressing tumor growth by targeting Nedd8-activating enzyme (NAE). In this study, 42 benzimidazole derivatives were designed and synthesized based on lead compound CDC to improve the neddylation inhibition and anticancer efficacy. Optimal benzimidazole-derived 35 displayed superior neddylation inhibition in enzyme assay compared to CDC (IC50 = 5.51 mu M vs 16.43 mu M), along with promising target inhibitory activity and killing selectivity in cancer cell. The results of cellular mechanism research combined with tumor growth suppression in human lung cancer cell A549 in vivo, accompanied with docking model, revealed that 35 has the potential to be developed as a promising neddylation inhibitor for anticancer therapy. (C) 2020 Elsevier Masson SAS. All rights reserved.

Category: amides-buliding-blocks. About Diphenylmethanamine, If you have any questions, you can contact Chen, X; Yang, X; Mao, F; Wei, JL; Xu, YX; Li, BL; Zhu, J; Ni, SS; Jia, LJ; Li, J or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Computed Properties of C13H13N. I found the field of Chemistry very interesting. Saw the article Reactions between 5-Nitroso-1,3-diphenyltetrazolium Salts and Electron-Rich Arenes, Amines, Thiophenol, Sulfoxides, and Thioanisole published in 2019.0, Reprint Addresses Hirashita, T (corresponding author), Nagoya Inst Technol, Grad Sch Engn, Life Sci & Appl Chem, Showa Ku, Gokiso Cho, Nagoya, Aichi 4668555, Japan.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine.

A series of reactions between 5-nitroso-1,3-diphenyltetrazolium tetrafluoroborate and methoxybenzenes, amines, thiols, sulfoxides, and sulfides, most of which are generally accepted as being inert to nitroso groups, is reported here. The tetrazolium-activated nitroso functionality is capable of oxidizing the aforementioned substrates to give the corresponding oxidized products, and the nitroso tetrazolium itself is transformed into the corresponding amide or hydroxyamide, depending on the nature of the reaction partners. In the case of thioanisole, an addition product was obtained.

Computed Properties of C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Matsukawa, Y; Hirashita, T; Araki, S or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Efficient synthesis of cyclic amidine-based fluorophores via 6 pi-electrocyclic ring closure WOS:000525512500017 published article about ONE-POT SYNTHESIS; FLUORESCENT-PROBES; SULFONYL; REARRANGEMENT; TACHYKININ; ALKYNES; ACCESS; FUNCTIONALIZATION; 1,2,3-TRIAZOLES; ANNULATION in [Li, Guofeng; Zhao, Man; Yao, Ying; Xu, Jiecheng; Xue, Jianzhong; Hu, Tao; Li, Min; Hong, Liang] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Key Lab Chiral Mol & Drug Discovery, Guangzhou 510006, Peoples R China; [Xie, Junqiu; Mou, Lingyun; Zhang, Xiaowei; Guo, Xiaomin; Sun, Wangsheng; Zhang, Ming] Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China; [Wang, Zheng] Peking Univ, Sch Chem Biol & Biotechnol, Guangdong Key Lab Nanomicro Mat Res, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China in 2020, Cited 67. SDS of cas: 104-10-9. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

Novel 10 pi-electron cyclic amidines with excellent fluorescence properties were synthesized by a general and efficient 6 pi-electrocyclic ring closure of ketenimine and imine starting from N-sulfonyl triazoles and arylamines. The photophysical properties of cyclic amidine fluorophores have been studied in detail and have shown good properties of a large Stokes shift, pH insensitivity, low cytotoxicity and higher photostability, which have great potential for biological imaging. Furthermore, this novel fluorophore was successfully applied to the localization of the NK-1 receptor in living systems.

About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Li, GF; Zhao, M; Xie, JQ; Yao, Y; Mou, LY; Zhang, XW; Guo, XM; Sun, WS; Wang, Z; Xu, JC; Xue, JZ; Hu, T; Zhang, M; Li, M; Hong, L or concate me.. SDS of cas: 104-10-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article A Novel Prodrug of a nNOS Inhibitor with Improved Pharmacokinetic Potential WOS:000579806900001 published article about NITRIC-OXIDE SYNTHASE; SELECTIVE-INHIBITION; DERIVATIVES; AGENT; IDENTIFICATION; ACETAMIDINES; AMIDOXIME; COMPONENT; THERAPY; AMIDINE in [Maccallini, Cristina; Marinelli, Lisa; Cacciatore, Ivana; Fantacuzzi, Marialuigia; Di Stefano, Antonio; Amoroso, Rosa] Univ G dAnnunzio, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy; [Indorf, Patrick; Clement, Bernd] Univ Kiel, Inst Pharmaceut, Gutenbergstr 76, D-24118 Kiel, Germany in 2020.0, Cited 48.0. Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Under different pathological conditions, aberrant induction of neuronal nitric oxide synthase (nNOS) generates overproduction of NO that can cause irreversible cell damage. The aim of this study was to develop an amidoxime prodrug of a potent nNOS inhibitor, the benzhydryl acetamidine. We synthesized the benzhydryl acetamidoxime, which was evaluatedin vitroto ascertain the potential NOS inhibitory activity, as well as conducting bioconversion into the parent acetamidine. The prodrug was also profiled forin vitrophysicochemical properties, by determining the lipophilicity, passive permeation through the human gastrointestinal tract and across the blood-brain barrier by PAMPA, and chemical, enzymatic, and plasma stability. The obtained data demonstrate that the amidoxime prodrug shows an improved pharmacokinetic profile with respect to the acetamidine nNOS inhibitor, thus suggesting that it could be a promising lead compound to treat all those pathological conditions in which nNOS activity is dysregulated.

About Diphenylmethanamine, If you have any questions, you can contact Maccallini, C; Marinelli, L; Indorf, P; Cacciatore, I; Fantacuzzi, M; Clement, B; Di Stefano, A; Amoroso, R or concate me.. Formula: C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Efficient synthesis of cyclic amidine-based fluorophores via 6 pi-electrocyclic ring closure published in 2020. Formula: C8H11NO, Reprint Addresses Li, M; Hong, L (corresponding author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Key Lab Chiral Mol & Drug Discovery, Guangzhou 510006, Peoples R China.. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol

Novel 10 pi-electron cyclic amidines with excellent fluorescence properties were synthesized by a general and efficient 6 pi-electrocyclic ring closure of ketenimine and imine starting from N-sulfonyl triazoles and arylamines. The photophysical properties of cyclic amidine fluorophores have been studied in detail and have shown good properties of a large Stokes shift, pH insensitivity, low cytotoxicity and higher photostability, which have great potential for biological imaging. Furthermore, this novel fluorophore was successfully applied to the localization of the NK-1 receptor in living systems.

Formula: C8H11NO. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Li, GF; Zhao, M; Xie, JQ; Yao, Y; Mou, LY; Zhang, XW; Guo, XM; Sun, WS; Wang, Z; Xu, JC; Xue, JZ; Hu, T; Zhang, M; Li, M; Hong, L or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics