Month: October 2021

Authors Zhang, GJ; Tang, FY; Wang, XY; An, P; Wang, LQ; Liu, YN in AMER CHEMICAL SOC published article about CHEMOSELECTIVE HYDROGENATION; SELECTIVE HYDROGENATION; EFFICIENT HYDROGENATION; CATALYTIC-HYDROGENATION; PD NANOPARTICLES; OXIDE CATALYSTS; UNIQUE APPROACH; PERFORMANCE; REDUCTION; MECHANISM in [Zhang, Guangji; Tang, Feiying; An, Ping; Wang, Liqiang; Liu, You-Nian] Cent South Univ, Hunan Prov Key Lab Micro & Nano Mat Interface Sci, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China; [Zhang, Guangji; Wang, Liqiang; Liu, You-Nian] Cent South Univ, State Key Lab Powder Met, Changsha 410083, Hunan, Peoples R China; [Wang, Xiaoying] Qilu Univ Technol, State Key Lab Biobased Mat & Green Papermaking, Jinan 250353, Shandong, Peoples R China in 2020.0, Cited 55.0. SDS of cas: 104-10-9. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

It is a persistent target to develop noble-metal-free catalysts that can achieve chemoselective hydrogenation of nitro compounds under mild reaction conditions. In this work, we report a new strategy for preparation of hydrogenation catalysts containing both CoNx and CoyZnS supported on N-doped porous carbon (CoNx-CoyZnS@NPC-Z). The CoNx-CoyZnS@NPC-Z catalysts were prepared by pyrolyzing the protein-metal-ion networks, followed by treatment with acid. We found that CoNxCoyZnS@NPC-3 catalyst delivers high catalytic activity and selectivity, affording almost full conversion and >98% selectivity in water/methanol mixture solvents at 90 degrees C under 5 bar of H-2 pressure for 3 h of reaction. Notably, the catalytic hydrogenation can work even under 1 bar of H-2 pressure and at room temperature with high conversion and selectivity. Besides, CoNx-CoyZnS@NPC-3 exhibits remarkable tolerance to CO or H2S poisoning and acid erosion.

About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Zhang, GJ; Tang, FY; Wang, XY; An, P; Wang, LQ; Liu, YN or concate me.. SDS of cas: 104-10-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Dithiin diisoimides: Synthesis and their antimicrobial studies WOS:000576795600004 published article about SUCCINAMIC ACID; 1,4-DITHIINS; BINDING; ESTER in [Ahme, Sumbul; Perveen, Shahnaz] Pakistan Council Sci & Ind Res, Labs Complex, Karachi 75280, Pakistan; [Perveen, Shahnaz; Khan, Khalid Mohammed; Naz, Farzana] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan; [Ali, Rahat Azher] Univ Karachi, Dept Chem, Karachi 75270, Pakistan; [Ajaz, Munazza; Shah, Samreen] Fed Urdu Univ Arts Sci & Technol, Dept Chem, Univ Rd,Gulshan E Iqbal Campus, Karachi, Pakistan; [Khan, Khalid Mohammed] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Clin Pharm, Dammam, Saudi Arabia in 2020.0, Cited 28.0. Application In Synthesis of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Sixteen derivatives of dithiin diisoimide 2a-2p have been synthesized and screened for antibacterial and antifungal activity. Compounds 2a-2g and 2i-2p are almost same or more active than gentamicine against Acinetobacter. Whereby compound 2,6-didodecyl-1H,5H-pyrrolo[3′,4′,5,6][1,4]dithiino[2,3-c]pyrrole-1,3,5,7(2H,6H)-tetrone (2d) having zone of inhibition 20 mm against Acinetobacter is the most potent among all these compounds and can be used as lead compound for the treatment of Acinetobacter infection.

About Diphenylmethanamine, If you have any questions, you can contact Ahme, S; Perveen, S; Khan, KM; Naz, F; Ali, RA; Ajaz, M; Shah, S or concate me.. Application In Synthesis of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors El Rayes, SM; Ali, IAI; Fathalla, W; Mahmoud, MAA in AMER CHEMICAL SOC published article about PHARMACOLOGICAL EVALUATION; LIGANDS; GROWTH in [El Rayes, Samir M.; Ali, Ibrahim A. I.; Mahmoud, Mostafa A. A.] Suez Canal Univ, Fac Sci, Dept Chem, Ismailia 41529, Egypt; [Fathalla, Walid] Port Said Univ, Fac Engn, Phys & Math Engn Dept, Port Said 42526, Egypt in 2020, Cited 24. Application In Synthesis of Benzo[d][1,2,3]triazin-4(3H)-one. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4

In one-pot strategy, diazotization of methyl anthranilate 5 followed by addition of amino acid ester hydrochloride, we have prepared methyl-2-(4-oxobenzotriazin-3(4H)-yl)-alkanoates 6a-c. Starting with hydrazides 7a,b, N-alkyl-2-(4-oxobenzotriazin-3(4H)-yl)-alkanamides 9-10(a-h) and methyl-2-(2-(4-oxobenzotriazin-3(4H)-yl)alkanamido)alkanoates 11- 12(a-e) were prepared via azide coupling. Hydrazones 13-15 were prepared via condensation of hydrazides 7a,b with 4-methoxybenzaldehyde, 4-dimethylaminobenzaldehyde, and/or arabinose. Molecular docking was done for synthesized compounds using MOE 2008-10 software. The compounds 9a, 12a, 12c, 13a, 13b, and 14b have the most pronounced strong binding affinities toward the target E. coli Fab-H receptor, whereas compounds 3, 11e, 12e, and 13a have the most pronounced strong binding affinities toward the target vitamin D receptor. The in vitro antibacterial activities of the highest binding affinity docked compounds were tested against E. coli, Staphylococcus aureus, and Salmonella spp. Majority of the tested compounds showed effective positive results against E. coli, while they were almost inactive against Staphylococcus aureus and Salmonella spp. The in vitro cytotoxic activities of the highest binding affinity-docked compounds were tested against the human liver carcinoma cell line (HepG2). Some compounds showed potent cytotoxic activity with low IC50 values, especially for 3 (6.525 mu M) and 13a (10.97 mu M) than that for standard drug doxorubicin (2.06 mu M).

About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact El Rayes, SM; Ali, IAI; Fathalla, W; Mahmoud, MAA or concate me.. Application In Synthesis of Benzo[d][1,2,3]triazin-4(3H)-one

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

An article Visible-light-induced denitrogenative phosphorylation of benzotriazinones: a metal- and additive-free method for accessing ortho-phosphorylated benzamide derivatives WOS:000608623000013 published article about ALKYNE INSERTION; LIGANDS; ACIDS; ANNULATION; 1,2,3-BENZOTRIAZIN-4(3H)-ONES in [Tang, Guo] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China; Xiamen Univ, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Fujian, Peoples R China in 2021, Cited 54. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4. Formula: C7H5N3O

Metal-free, visible-light-induced denitrogenative phosphorylation of 1,2,3-benzotriazinones was achieved. With the use of eosin Y as a photoredox catalyst, N,N-diisopropylethylamine as a base, CH3CN-H2O as a solvent and sunlight or a blue LED as a light source, a variety of aryl-phosphonates, aryl-phosphinates, and aryl-phosphine oxides were efficiently prepared. In addition, B(2)pin(2) instead of P-nucleophiles as a radical acceptor was also demonstrated. The key advantages of this newly developed method are the clean reaction profile, use of a low-cost organic-dye catalyst, energy efficiency, broad substrate scope, good to excellent yields and large-scale synthetic applicability. The gram-scale synthesised compounds could be isolated in pure form just upon extraction, followed by re-crystallisation; no tedious chromatographic purification was required.

Formula: C7H5N3O. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Chen, FS; Hu, SS; Li, SP; Tang, G; Zhao, YF or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Authors Zhang, RF; Guo, W; Wang, GL; Chen, XL; Li, Z; Xu, XY in PERGAMON-ELSEVIER SCIENCE LTD published article about SYSTEMIC ACQUIRED-RESISTANCE; ROTYLENCHULUS-RENIFORMIS; ELICITORS; NEMATICIDES; EFFICACY; TOMATO; PLANTS; SPP. in [Zhang, Ruifeng; Wang, Gaolei; Chen, Xiulei; Li, Zhong; Xu, Xiaoyong] East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China; [Guo, Wei] China Crop Protect Ind Assoc, Beijing 100723, Peoples R China in 2020, Cited 28. Name: Benzo[d][1,2,3]triazin-4(3H)-one. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4

Based on the characteristic of benzo[d][1,2,3]thiadiazole to induce the systemic acquired resistance and improve the immunity of plants, benzo[d][1,2,3]thiadiazole was introduced into 1,2,3-benzotriazin-4-one, thirty-one novel 1,2,3-benzotriazin-4-one derivatives containing benzo[d][1,2,3]thiadiazole were designed and synthesized. Nematicidal activity showed that most of the synthesized compounds exhibited great inhibitory activity in vivo against Meloidogyne incognita at 20 mg/L. Among 31 tested compounds, A2 and A3 showed an excellent nematicidal activity with the inhibition rate of 50.4% and 53.1% at the concentration of 1.0 mg/L, respectively. The influence of substituent type and position was investigated. The relationship between structure and activity was also preliminary analyzed.

Name: Benzo[d][1,2,3]triazin-4(3H)-one. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Zhang, RF; Guo, W; Wang, GL; Chen, XL; Li, Z; Xu, XY or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Formula: C7H5N3O. Recently I am researching about BACTERIAL SYMBIONTS; GLYCOLYSIS; CANCER; GERMINATION; ANSAMYCIN; PROVIDE, Saw an article supported by the National Science Foundation of Shandong ProvinceNatural Science Foundation of Shandong Province [ZR2014HM018]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31741048]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Zhang, XM; Peng, AH; Xie, WD; Wang, M; Zheng, D; Feng, MK. The CAS is 90-16-4. Through research, I have a further understanding and discovery of Benzo[d][1,2,3]triazin-4(3H)-one

Insect-microbial symbioses have vast biochemical diversity, which is beneficial to produce bioactive secondary metabolites. In this study, chemical examination of a Streptomyces sp. associated with a mud dauber wasp led to the isolation of fourteen compounds. Their structures were determined by spectroscopic methods and comparison with literature data. Among the isolates, compounds 1,2,3-benzotriazin-4(1H)-one and 4-(2-aminoethyl)phenyl acetate were first reported from this species. Bioactivities of the isolated compounds were assayed for the first time against hexokinase II. 4-(2-Aminoethyl)phenyl acetate, germicidin B, phenylacetic acid, isogermicidin A and germicidin C displayed significant inhibitory activity against hexokinase II, with the IC50 values of 5.11, 7.11, 7.15, 8.45 and 8.78 mu M, respectively.

Formula: C7H5N3O. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Zhang, XM; Peng, AH; Xie, WD; Wang, M; Zheng, D; Feng, MK or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Authors Reddy, GS; Snehalatha, AV; Edwin, RK; Hossain, KA; Giliyaru, VB; Hariharapura, RC; Shenoy, GG; Misra, P; Pal, M in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about 1,2,3-BENZOTRIAZIN-4-ONE DERIVATIVES; NEMATOCIDAL ACTIVITIES; INDOLES; 1-ALKYNES; RV1885C; 2-HETEROARYL; DOCKING; PROTEIN; 2-ARYL in [Reddy, Gangireddy Sujeevan; Snehalatha, Ampalam Venkata; Edwin, Rebecca Kristina; Hossain, Kazi Amirul; Misra, Parimal; Pal, Manojit] Dr Reddys Inst Life Sci, Univ Hyderabad Campus, Hyderabad 500046, India; [Reddy, Gangireddy Sujeevan; Giliyaru, Varadaraj Bhat; Hariharapura, Raghu Chandrashekhar; Shenoy, G. Gautham] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal 576104, Karnataka, India in 2019, Cited 38. Quality Control of Benzo[d][1,2,3]triazin-4(3H)-one. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4

The chorismate mutase (CM) is considered as an attractive target for the identification of potential antitubercular agents due to its absence in animals but not in bacteria. A series of 3-indolylmethyl substituted pyrazolo-triazinone derivatives were designed and docked into CM in silico as potential inhibitors. These compounds were efficiently synthesized using the Pd/Cu-catalyzed coupling-cyclization in a single pot involving the construction of indole ring. The methodology was later extended to the preparation of corresponding benzo analogs of pyrazolotriazinones i.e. 3-indolylmethyl substituted benzotriazinone derivatives. Several of these novel compounds showed significant inhibition of CM when tested in vitro at 30 mu M. The SAR (Structure-Activity-Relationship) studies suggested that benzotriazinone moiety was more favorable over the pyrazolotriazinone ring. The two best active compounds showed IC50 similar to 0.4-0.9 mu M (better than the reference/known compounds used) and no toxicity till 30 mu M in vitro.

Quality Control of Benzo[d][1,2,3]triazin-4(3H)-one. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Reddy, GS; Snehalatha, AV; Edwin, RK; Hossain, KA; Giliyaru, VB; Hariharapura, RC; Shenoy, GG; Misra, P; Pal, M or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

An article Absolute asymmetric Strecker synthesis in a mixed aqueous medium: reliable access to enantioenriched alpha-aminonitrile WOS:000457797000024 published article about CHIRAL-SYMMETRY-BREAKING; AMINO-ACIDS; ENANTIOSELECTIVE SYNTHESIS; ENANTIOMERIC EXCESS; PYRIMIDYL ALKANOL; AMPLIFICATION; AUTOCATALYSIS; ORIGIN; CRYSTALLIZATION; CONJUNCTION in [Miyagawa, Shinobu; Aiba, Shohei; Kawamoto, Hajime; Tokunaga, Yuji] Univ Fukui, Dept Mat Sci & Engn, Bunkyo Ku, Fukui 9108507, Japan; [Kawasaki, Tsuneomi] Tokyo Univ Sci, Dept Appl Chem, Shinjyuku Ku, Tokyo 1628601, Japan in 2019.0, Cited 48.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Category: amides-buliding-blocks

Without using chiral sources, the Strecker reaction of achiral hydrogen cyanide, p-tolualdehyde and benzhydrylamine gave enantioenriched L- or D-N-benzhydryl-alpha-( p-tolyl) glycine nitriles with up to > 99% ee in a mixed solvent of water and methanol. Therefore, total spontaneous resolution of alpha-aminonitriles could occur through a prebiotic mechanism of alpha-amino acid synthesis. Moreover, it was demonstrated that the repetition of partial dissolution and crystallization of a suspended conglomerate of aminonitrile under solution-phase racemization could generate the enantiomeric imbalance to afford, in combination with the amplification of chirality, an enantioenriched product in every case. Among the 73 experiments that were carried out, D-and L-enriched isomers occurred 36 and 37 times, respectively. This stochastic behavior, under achiral or racemic starting conditions, meets the requirements of the spontaneous absolute asymmetric Strecker synthesis. The implications of the present results for the origin of chirality of alpha-amino acids are discussed.

Category: amides-buliding-blocks. About Diphenylmethanamine, If you have any questions, you can contact Miyagawa, S; Aiba, S; Kawamoto, H; Tokunaga, Y; Kawasaki, T or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Synthesis and Antiplasmodial Activity of Novel Fosmidomycin Derivatives and Conjugates with Artemisinin and Aminochloroquinoline WOS:000585492000001 published article about PHOSPHONIC ACID ANTIBIOTICS; ISOPRENOID BIOSYNTHESIS; ANTIMALARIAL; FR900098; ANALOGS; INHIBITORS; FR-31564; PATHWAY; ANTIBACTERIAL; DESIGN in [Palla, Despina; Antoniou, Antonia I.; Athanassopoulos, Constantinos M.] Univ Patras, Dept Chem, Synthet Organ Chem Lab, GR-26504 Patras, Greece; [Baltas, Michel; Menendez, Christophe] Univ Paul Sabatier Toulouse III, UMR CNRS 5068, LSPCMIB, F-31062 Toulouse 9, France; [Baltas, Michel; Menendez, Christophe] Univ Tolouse, CNRS, LCC Lab Chim Coordinat, UPS,INPT, 205 Route Narbonne,BP 44099, F-31077 Toulouse 4, France; [Grellier, Philippe; Mouray, Elisabeth] Museum Natl Hist Nat, CNRS, UMR 7245, MCAM, CP52,63 Rue Buffon, F-75005 Paris, France in 2020.0, Cited 45.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Safety of Diphenylmethanamine

Malaria, despite many efforts, remains among the most problematic infectious diseases worldwide, mainly due to the development of drug resistance by Plasmodium falciparum. The antibiotic fosmidomycin (FSM) is also known for its antimalarial activity by targeting the non-mevalonate isoprenoid synthesis pathway, which is essential for the malaria parasites but is absent in mammalians. In this study, we synthesized and evaluated against the chloroquine-resistant P. falciparum FcB1/Colombia strain, a series of FSM analogs, derivatives, and conjugates with other antimalarial agents, such as artemisinin (ART) and aminochloroquinoline (ACQ). The biological evaluation revealed four new compounds with higher antimalarial activity than FSM: two FSM-ACQ derivatives and two FSM-ART conjugates, with 3.5-5.4 and 41.5-23.1 times more potent activities than FSM, respectively.

Safety of Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Palla, D; Antoniou, AI; Baltas, M; Menendez, C; Grellier, P; Mouray, E; Athanassopoulos, CM or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Oxidative Olefination of Benzylamine with an Active Methylene Compound Mediated by Hypervalent Iodine (III) WOS:000487140200001 published article about ONE-POT SYNTHESIS; CATALYZED KNOEVENAGEL CONDENSATION; METAL-ORGANIC FRAMEWORK; FACILE SYNTHESIS; CHEMOSELECTIVE REDUCTION; GREEN PROCEDURE; IONIC LIQUID; EFFICIENT; NITRILES; HYDRATION in [Rupanawar, Bapurao D.; Suryavanshi, Gurunath] CSIR, Natl Chem Lab, Chem Engn & Proc Dev Div, Dr Homi Bhaba Rd, Pune 411008, Maharashtra, India; [Rupanawar, Bapurao D.; Suryavanshi, Gurunath] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, Uttar Pradesh, India; [Veetil, Sruthi M.] CSIR, Natl Chem Lab, Cent NMR Facil, Dr Homi Shaba Rd, Pune 411008, Maharashtra, India in 2019, Cited 74. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Application In Synthesis of Diphenylmethanamine

Hypervalent iodine-mediated oxidative olefination of amines with an active methylene compound provides a rapid gateway towards the formation of electrophilic alkenes under mild reaction conditions in good to excellent yields. This is an efficient protocol for the preparation of substituted electrophilic alkenes.

Application In Synthesis of Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Rupanawar, BD; Veetil, SM; Suryavanshi, G or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics