Month: October 2021

Authors Giampietro, L; Laghezza, A; Cerchia, C; Florio, R; Recinella, L; Capone, F; Ammazzalorso, A; Bruno, I; De Filippis, B; Fantacuzzi, M; Ferrante, C; Maccallini, C; Tortorella, P; Verginelli, F; Brunetti, L; Cama, A; Amoroso, R; Loiodice, F; Lavecchia, A in AMER CHEMICAL SOC published article about BINDING; MECHANISMS; INSIGHTS; ACID in [Giampietro, Letizia; Florio, Rosalba; Recinella, Lucia; Ammazzalorso, Alessandra; Bruno, Isabella; De Filippis, Barbara; Fantacuzzi, Marialuigia; Ferrante, Claudio; Maccallini, Cristina; Verginelli, Fabio; Brunetti, Luigi; Cama, Alessandro; Amoroso, Rosa] Univ G dAnnunzio, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy; [Laghezza, Antonio; Tortorella, Paolo; Loiodice, Fulvio] Univ Bari Aldo Moro, Dept Pharm Drug Sci, Via E Orabona 4, I-70126 Bari, Italy; [Cerchia, Carmen; Capone, Fabio; Lavecchia, Antonio] Univ Napoli Federico II, Drug Discovery Lab, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy; [Florio, Rosalba; Verginelli, Fabio; Cama, Alessandro] Univ G dAnnunzio, Ctr Aging Sci & Translat Med CeSI MeT, Via Luigi Polacchi 11, I-66100 Chieti, Italy in 2019.0, Cited 30.0. Recommanded Product: 104-10-9. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

The development of PPAR alpha/gamma dual or PPAR alpha/gamma/S pan-agonists could represent an efficacious approach for a simultaneous pharmacological intervention on carbohydrate and lipid metabolism. Two series of new phenyldiazenyl fibrate derivatives of GL479, a previously reported PPAR alpha/gamma dual agonist, were synthesized and tested. Compound 12a was identified as a PPAR pan-agonist with moderate and balanced activity on the three PPAR isoforms (alpha, gamma, delta). Moreover, docking experiments showed that 12a adopts a different binding mode in PPARy compared to PPARa or PPARS, providing a structural basis for further structure-guided design of PPAR pan-agonists. The beneficial effects of 12a were evaluated both in vitro, on the expression of PPAR target key metabolic genes, and ex vivo in two rat tissue inflammatory models. The obtained results allow considering this compound as an interesting lead for the development of a new class of PPAR pan-agonists endowed with an activation profile exploitable for therapy of metabolic syndrome.

About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Giampietro, L; Laghezza, A; Cerchia, C; Florio, R; Recinella, L; Capone, F; Ammazzalorso, A; Bruno, I; De Filippis, B; Fantacuzzi, M; Ferrante, C; Maccallini, C; Tortorella, P; Verginelli, F; Brunetti, L; Cama, A; Amoroso, R; Loiodice, F; Lavecchia, A or concate me.. Recommanded Product: 104-10-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2019.0 RSC ADV published article about SECONDARY PHOSPHINE OXIDES; AEROBIC OXIDATION; N-ALKYLATION; PALLADIUM; FUNCTIONALIZATION; METHODOLOGY; CHEMISTRY; ALCOHOLS in [Membrat, Romain; Moraleda, Delphine; Michaud-Chevallier, Sabine; Martinez, Alexandre; Giordano, Laurent; Nuel, Didier] Aix Marseille Univ, CNRS, Cent Marseille, ISm2, F-ISM2 Marseille, France; [Vasseur, Alexandre] Univ Lorraine, CNRS, L2CM, F-54000 Nancy, France in 2019.0, Cited 31.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. SDS of cas: 91-00-9

Platinum-(phosphinito-phosphinous acid) complex catalyzes the oxidative fragmentation of hindered piperidinols according to a hydrogen transfer induced methodology. This catalyst acts successively as both a hydrogen carrier and soft Lewis acid in a one pot – two steps process. This method can be applied to the synthesis of a wide variety of primary amines in a pure form by a simple acid-base extraction without further purification.

SDS of cas: 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Membrat, R; Vasseur, A; Moraleda, D; Michaud-Chevallier, S; Martinez, A; Giordano, L; Nuel, D or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recommanded Product: 91-00-9. Authors Karteek, SD; Reddy, AG; Tej, MB; Rao, MVB in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about in [Karteek, S. Durga] Koneru Lakshmaiah Educ Fdn, Dept Chem, Vaddeswaram 522502, India; [Reddy, A. Gopi] SANA Coll Pharm, Dept Pharm, Kodad 508206, India; [Tej, M. Bhuvan] Sri Ramachandra Med Coll & Res Inst, Dept Pharm, Chennai 600116, Tamil Nadu, India; [Rao, M. V. Basaveswara] Krishna Univ, Dept Chem, Machilipatnam 521001, India in 2021.0, Cited 38.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A new series of fused tricyclic coumarin derivatives were designed, synthesized by a simple and convenient method, starting from 4-hydroxycoumarin and virtually screened by molecular docking on the target protein 3FRZ (PDB ID: 3FRZ), a HCV RNA-dependent RNA polymerase, for potency against hepatitis C virus (HCV). Efficient binding to the target protein was found for most of the synthesized compounds.

Recommanded Product: 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Karteek, SD; Reddy, AG; Tej, MB; Rao, MVB or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article General synthesis of primary amines via reductive amination employing a reusable nickel catalyst WOS:000455845400014 published article about AQUEOUS AMMONIA; SELECTIVE HYDROGENATION; IRON CATALYSTS; ALKYLATION; ALCOHOLS; KETONES; ACIDS; FURFURYLAMINE; NANOPARTICLES; NITROARENES in [Hahn, G.; Kempe, R.] Univ Bayreuth, Chair Inorgan Chem II Catalyst Design, Bayreuth, Germany; [Kunnas, P.; de Jonge, N.] INM Leibniz Inst New Mat, Saarbrucken, Germany; [de Jonge, N.] Saarland Univ, Dept Phys, Saarbrucken, Germany in 2019, Cited 54. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Quality Control of Diphenylmethanamine

Reusable catalysts based on earth-abundant metals with a broad applicability in organic synthesis are a key to a more sustainable production of fine chemicals, pharmaceuticals and agrochemicals. Herein, we report on a nanostructured nickel catalyst for the general and selective synthesis of primary amines via reductive amination, employing ammonia dissolved in water. Our catalyst, which operates at low temperature and pressure, is highly active, reusable and easy to handle. The synthesis from a specific nickel complex and gamma-Al2O3 is straightforward, with the ligand-metal combination of this complex being crucial. Aldehydes (including purely aliphatic ones), aryl-alkyl, dialkyl and diaryl ketones can all be converted smoothly into primary amines. In addition, the amination of pharmaceuticals, bioactive compounds and natural products is demonstrated. Many functional groups-including hydrogenation-sensitive examples-are tolerated. We expect that our findings will inspire others to develop reusable and nanostructured earth-abundant metal catalysts for complex organic transformations.

About Diphenylmethanamine, If you have any questions, you can contact Hahn, G; Kunnas, P; de Jonge, N; Kempe, R or concate me.. Quality Control of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Modular quadruplex-duplex hybrids as biomolecular scaffolds for asymmetric Michael addition reactions published in 2020.0. Safety of 2-(4-Aminophenyl)ethanol, Reprint Addresses Sugiyama, H; Park, S (corresponding author), Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kitashirakawa Oiwakecho, Kyoto 6068502, Japan.; Sugiyama, H (corresponding author), Kyoto Univ, Inst Integrated Cell Mat Sci iCeMS, Sakyo Ku, Yoshida Ushinomiyacho, Kyoto 6068501, Japan.. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol

Asymmetric synthesis based on DNA scaffolds has been actively exploited because of the advantages of DNA such as diverse tertiary structures, chemical stability, and easy handling. Since duplex DNA-based hybrid catalysts have demonstrated this remarkable capability, efforts have been made to investigate new biomolecular scaffolds. Herein, we report modular quadruplex-duplex (QD) hybrid DNA catalysts containing bipyridine ligands and hydrogen donor moieties. The conformation, thermal stability, and metal-binding ability of modified QD hybrid DNA were characterized using spectroscopy. The QD hybrid-based DNA catalysts were successfully applied to asymmetric Michael addition reactions (86% conversion and 76% ee). This study describes a new type of DNA hybrid catalyst produced by the construction of a cooperative active site with a Lewis acid and a H-bond donor.

About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Yum, JH; Sugiyama, H; Park, S or concate me.. Safety of 2-(4-Aminophenyl)ethanol

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article NaNO2/I-2 as an alternative reagent for the synthesis of 1,2,3-benzotriazin-4(3H)-ones from 2-aminobenzamides WOS:000456353000009 published article about CATALYZED DENITROGENATIVE ANNULATION; TERT-BUTYL NITRITE; NEMATOCIDAL ACTIVITIES; SELECTIVE SYNTHESIS; DERIVATIVES; 1,2,3-BENZOTRIAZINE-4-(3H)-ONES; ACID in [Barak, Dinesh S.; Mukhopadhyay, Sushobhan; Dahatonde, Dipak J.; Batra, Sanjay] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Sect 10,Jankipuram Extens,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India; [Batra, Sanjay] CSIR HRDC, Postal Staff Coll Area, Sect 19, Ghaziabad 201002, India in 2019, Cited 39. COA of Formula: C7H5N3O. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4

An efficient transformation of 2-aminobenzamides to 1,2,3-benzotriazin-4(3H)-ones in the presence of sodium nitrite (NaNO2) and Iodine (I-2) is described. The reaction is proposed to proceed via formation of nitrosyl halide that induces nitrosylation of the amino group of 2-aminobenzamide leading to diazotization followed by intramolecular cyclization. (C) 2018 Elsevier Ltd. All rights reserved.

COA of Formula: C7H5N3O. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Barak, DS; Mukhopadhyay, S; Dahatonde, DJ; Batra, S or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: 91-00-9. In 2020.0 GREEN CHEM published article about EFFICIENT RECYCLABLE CATALYST; DBN TETRAPHENYLBORATE SALTS; DIRECT AMIDATION; CARBOXYLIC-ACIDS; HIGHLY EFFICIENT; SILICA-GEL; ALCOHOLS; AMINES; PHENOLS; SOLVENT in [Ghosh, Santanu; Purkait, Anisha; Jana, Chandan K.] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India in 2020.0, Cited 76.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

An operationally simple and general method for acetylation and acylation of a wide variety of substrates (amines, alcohols, phenols, thiols, and hydrazones) has been reported. Meldrum’s acid and its derivatives have been used as an air-stable, non-volatile, cost-effective, and easy to handle acetylating/acylating agent. Easily separable byproducts (CO2 and acetone) allowed the isolation of analytically pure acetylated products without the requirement of work-up and any chromatography.

Recommanded Product: 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Ghosh, S; Purkait, A; Jana, CK or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Efficient synthesis of cyclic amidine-based fluorophores via 6 pi-electrocyclic ring closure WOS:000525512500017 published article about ONE-POT SYNTHESIS; FLUORESCENT-PROBES; SULFONYL; REARRANGEMENT; TACHYKININ; ALKYNES; ACCESS; FUNCTIONALIZATION; 1,2,3-TRIAZOLES; ANNULATION in [Li, Guofeng; Zhao, Man; Yao, Ying; Xu, Jiecheng; Xue, Jianzhong; Hu, Tao; Li, Min; Hong, Liang] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Key Lab Chiral Mol & Drug Discovery, Guangzhou 510006, Peoples R China; [Xie, Junqiu; Mou, Lingyun; Zhang, Xiaowei; Guo, Xiaomin; Sun, Wangsheng; Zhang, Ming] Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China; [Wang, Zheng] Peking Univ, Sch Chem Biol & Biotechnol, Guangdong Key Lab Nanomicro Mat Res, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China in 2020, Cited 67. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9. Quality Control of 2-(4-Aminophenyl)ethanol

Novel 10 pi-electron cyclic amidines with excellent fluorescence properties were synthesized by a general and efficient 6 pi-electrocyclic ring closure of ketenimine and imine starting from N-sulfonyl triazoles and arylamines. The photophysical properties of cyclic amidine fluorophores have been studied in detail and have shown good properties of a large Stokes shift, pH insensitivity, low cytotoxicity and higher photostability, which have great potential for biological imaging. Furthermore, this novel fluorophore was successfully applied to the localization of the NK-1 receptor in living systems.

About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Li, GF; Zhao, M; Xie, JQ; Yao, Y; Mou, LY; Zhang, XW; Guo, XM; Sun, WS; Wang, Z; Xu, JC; Xue, JZ; Hu, T; Zhang, M; Li, M; Hong, L or concate me.. Quality Control of 2-(4-Aminophenyl)ethanol

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

HPLC of Formula: C13H13N. Recently I am researching about BOC PROTECTION; IONIC LIQUID; ORGANIC-SYNTHESIS; GREEN CHEMISTRY; ACID CATALYST; BUTOXYCARBONYLATION; MILD; TRANSAMIDATION; ORGANOCATALYST; TECHNOLOGY, Saw an article supported by the Planning and Development, Savitribai Phule Pune University, Pune under ASPIRE-Research Mentorship Program [18TEC001308]. Published in TAYLOR & FRANCIS INC in PHILADELPHIA ,Authors: Ingale, AP; Shinde, SV; Thorat, NM. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Sulfated tungstate catalyzed an efficient and ecofriendly protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at room temperature. The variety of functionalized aliphatic, aromatic and heteroaromatic amines efficiently undergoes the N-tert-butyloxycarbonylation under the developed protocol. The aminoalcohol, aminophenol, aminoester as well as various chiral amines underwent the chemoselective N-Boc protection under the optimized reaction condition. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.

HPLC of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Ingale, AP; Shinde, SV; Thorat, NM or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recommanded Product: 90-16-4. In 2020 CHEM BIODIVERS published article about BACTERIAL SYMBIONTS; GLYCOLYSIS; CANCER; GERMINATION; ANSAMYCIN; PROVIDE in [Zhang, Xiu-Mei; Wang, Mei; Zheng, Dan; Feng, Ming-Kuan] Shandong Drug & Food Vocat Coll, Dept Pharm, Weihai 264210, Peoples R China; [Peng, Ai-Hong; Xie, Wei-Dong] Shandong Univ, Coll Marine Sci, Dept Pharm, Weihai 264209, Peoples R China in 2020, Cited 43. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4.

Insect-microbial symbioses have vast biochemical diversity, which is beneficial to produce bioactive secondary metabolites. In this study, chemical examination of a Streptomyces sp. associated with a mud dauber wasp led to the isolation of fourteen compounds. Their structures were determined by spectroscopic methods and comparison with literature data. Among the isolates, compounds 1,2,3-benzotriazin-4(1H)-one and 4-(2-aminoethyl)phenyl acetate were first reported from this species. Bioactivities of the isolated compounds were assayed for the first time against hexokinase II. 4-(2-Aminoethyl)phenyl acetate, germicidin B, phenylacetic acid, isogermicidin A and germicidin C displayed significant inhibitory activity against hexokinase II, with the IC50 values of 5.11, 7.11, 7.15, 8.45 and 8.78 mu M, respectively.

Recommanded Product: 90-16-4. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Zhang, XM; Peng, AH; Xie, WD; Wang, M; Zheng, D; Feng, MK or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics