Recently I am researching about ACTIVATED RECEPTOR-ALPHA; PPAR-ALPHA; FENOFIBRATE; GROWTH; CELL; DRUGS; MELANOMA; METABOLISM; INHIBITION; PREDICTION, Saw an article supported by the School of Medicine, LSU Health Sciences Center [P20-GM121288-01]; STEPFARM, LLC; Faculty of Biochemistry, Biophysics and Biotechnology of Jagiellonian University-a partner of the Leading National Research Center (KNOW) – Ministry of Science and Higher Education; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [P20GM121288] Funding Source: NIH RePORTER. Recommanded Product: Diphenylmethanamine. Published in NATURE PUBLISHING GROUP in LONDON ,Authors: Stalinska, J; Houser, L; Rak, M; Colley, SB; Reiss, K; Jursic, BS. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine
Structural variations of the benzylphenoxyacetamide (BPA) molecular skeleton were explored as a viable starting point for designing new anti-glioblastoma drug candidates. Hand-to-hand computational evaluation, chemical modifications, and cell viability testing were performed to explore the importance of some of the structural properties in order to generate, retain, and improve desired anti-glioblastoma characteristics. It was demonstrated that several structural features are required to retain the anti-glioblastoma activity, including a carbonyl group of the benzophenone moiety, as well as 4′-chloro and 2,2-dimethy substituents. In addition, the structure of the amide moiety can be modified in such a way that desirable anti-glioblastoma and physical properties can be improved. Via these structural modifications, more than 50 compounds were prepared and tested for anti-glioblastoma activity. Four compounds were identified (HR28, HR32, HR37, and HR46) that in addition to HR40 (PP1) from our previous study, have been determined to have desirable physical and biological properties. These include high glioblastoma cytotoxicity at low mu M concentrations, improved water solubility, and the ability to penetrate the blood brain barrier (BBB), which indicate a potential for becoming a new class of anti-glioblastoma drugs.
Recommanded Product: Diphenylmethanamine. Welcome to talk about 91-00-9, If you have any questions, you can contact Stalinska, J; Houser, L; Rak, M; Colley, SB; Reiss, K; Jursic, BS or send Email.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics