Month: November 2021

Product Details of 91-00-9. Recently I am researching about ONE-POT SYNTHESIS; OXIDATIVE CARBONYLATION; EFFICIENT CONVERSION; TRISUBSTITUTED UREAS; BIOLOGICAL-ACTIVITY; CARBOXYLIC-ACIDS; AMINES; FACILE; INHIBITORS; DESIGN, Saw an article supported by the Science and Engineering Research Board (SERB), Department of Science & Technology, New Delhi [EMR/2016/001123]; Council of Scientific & Industrial Research (CSIR), New DelhiCouncil of Scientific & Industrial Research (CSIR) – India; University Grant Commission (UGC), New DelhiUniversity Grants Commission, India. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Singh, AS; Agrahari, AK; Singh, SK; Yadav, MS; Tiwari, VK. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

The good leaving tendency of the benzotriazole moiety has been exploited for the synthesis of symmetric, unsymmetric, N-acyl, and cyclic ureas in good yields from N-acylbenzotriazoles by treating the latter with various amines in the presence of TMSN N in a sealed tube. The salient features of the devised protocol includes the high-yield, mild, metal-free, one-pot reaction conditions, and short reaction time. Furthermore, in many cases, no column chromatography is required for the purification.

Welcome to talk about 91-00-9, If you have any questions, you can contact Singh, AS; Agrahari, AK; Singh, SK; Yadav, MS; Tiwari, VK or send Email.. Product Details of 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Evaluation of Synthesized Ester or Amide Coumarin Derivatives on Aromatase Inhibitory Activity published in 2020.0. Name: Diphenylmethanamine, Reprint Addresses Yamaguchi, Y; Nishizono, N (corresponding author), Hlth Sci Univ Hokkaido, Sch Pharmaceut Sci, Ishikari, Hokkaido 0610293, Japan.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Aromatase inhibitors are effective for the treatment of diseases such as breast cancer, which has led to an increase in their demand. However, only a limited number of aromatase inhibitor drugs are currently being marketed. In addition, considering the important aspect of drug resistance, the development of newer drug types is required. We have been developing inhibitors with backbone structures that differ from existing aromatase inhibitors. In this regard, we previously reported that diethylaminocoumarin dimers and thiazolyl coumarin derivatives possess strong aromatase inhibiting capabilities. In this study, we further examined the structure activity relationships of coumarin derivatives synthesized from thiazolyl coumarin derivatives and their aromatase inhibiting capabilities. Consequently, amide coumarin N-benzhydry1-7-(diethylamino)2-oxo-2H-chromene-3-carboxamide (IC50 values 4.5 mu M) is inhibitor of aromatase. This inhibitor was found to be comparable aromatase inhibitory activity to the 1st generation aromatase inhibitor aminoglutethimide (3.2 mu M). Substitution of the amide group on the amide coumarin derivative affects the aromatase inhibiting activity. Our findings suggest that the structure of each substituent changes the orientation of the compound in the active site of aromatase, thus creating a difference in their activities.

Welcome to talk about 91-00-9, If you have any questions, you can contact Yamaguchi, Y; Nishizono, N; Oda, K or send Email.. Name: Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2019 EUR J ORG CHEM published article about ONE-POT SYNTHESIS; CATALYZED KNOEVENAGEL CONDENSATION; METAL-ORGANIC FRAMEWORK; FACILE SYNTHESIS; CHEMOSELECTIVE REDUCTION; GREEN PROCEDURE; IONIC LIQUID; EFFICIENT; NITRILES; HYDRATION in [Rupanawar, Bapurao D.; Suryavanshi, Gurunath] CSIR, Natl Chem Lab, Chem Engn & Proc Dev Div, Dr Homi Bhaba Rd, Pune 411008, Maharashtra, India; [Rupanawar, Bapurao D.; Suryavanshi, Gurunath] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, Uttar Pradesh, India; [Veetil, Sruthi M.] CSIR, Natl Chem Lab, Cent NMR Facil, Dr Homi Shaba Rd, Pune 411008, Maharashtra, India in 2019, Cited 74. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Recommanded Product: 91-00-9

Hypervalent iodine-mediated oxidative olefination of amines with an active methylene compound provides a rapid gateway towards the formation of electrophilic alkenes under mild reaction conditions in good to excellent yields. This is an efficient protocol for the preparation of substituted electrophilic alkenes.

Welcome to talk about 91-00-9, If you have any questions, you can contact Rupanawar, BD; Veetil, SM; Suryavanshi, G or send Email.. Recommanded Product: 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Wang, L; Casey, MC; Vernekar, SKV; Do, HT; Sahani, RL; Kirby, KA; Du, HJ; Hachiya, A; Zhang, HC; Tedbury, PR; Xie, JS; Sarafianos, SG; Wang, ZQ in [Wang, Lei; Vernekar, Sanjeev Kumar V.; Do, Ha T.; Sahani, Rajkumar Lalji; Xie, Jiashu; Wang, Zhengqiang] Univ Minnesota, Coll Pharm, Ctr Drug Design, Minneapolis, MN 55455 USA; [Casey, Mary C.] Univ Missouri, Christopher S Bond Life Sci Ctr, Dept Mol Microbiol & Immunol, Sch Med, Columbia, MO 65211 USA; [Kirby, Karen A.; Du, Haijuan; Zhang, Huanchun; Tedbury, Philip R.; Sarafianos, Stefan G.] Emory Univ, Dept Pediat, Lab Biochem Pharmacol, Sch Med, Atlanta, GA 30322 USA; [Hachiya, Atsuko] Natl Hosp Org, Clin Res Ctr, Nagoya Med Ctr, Nagoya, Aichi 4600001, Japan; [Wang, Lei] Dalian Univ Technol, Sch Chem Engn, Dept Pharm, Dalian 116024, Peoples R China published Chemical profiling of HIV-1 capsid-targeting antiviral PF74 in 2020.0, Cited 51.0. SDS of cas: 91-00-9. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

The capsid protein (CA) of HIV-1 plays essential roles in multiple steps of the viral replication cycle by assembling into functional capsid core, controlling the kinetics of uncoating and nuclear entry, and interacting with various host factors. Targeting CA represents an attractive yet underexplored antiviral approach. Of all known CA-targeting small molecule chemotypes, the peptidomimetic PF74 is particularly interesting because it binds to the same pocket used by a few important host factors, resulting in highly desirable antiviral phenotypes. However, further development of PF74 entails understanding its pharmacophore and mitigating its poor metabolic stability. We report herein the design, synthesis, and evaluation of a large number of PF74 analogs aiming to provide a comprehensive chemical profiling of PF74 and advance the understanding on its detailed binding mechanism and pharmacophore. The analogs, containing structural variations mainly in the aniline domain and/or the indole domain, were assayed for their effect on stability of CA hexamers, antiviral activity, and cytotoxicity. Selected analogs were also tested for metabolic stability in liver microsomes, alone or in the presence of a CYP3A inhibitor. Collectively, our studies identified important pharmacophore elements and revealed additional binding features of PF74, which could aid in future design of improved ligands to better probe the molecular basis of CA-host factor interactions, design strategies to disrupt them, and ultimately identify viable CA-targeting antiviral leads. (C) 2020 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 91-00-9, If you have any questions, you can contact Wang, L; Casey, MC; Vernekar, SKV; Do, HT; Sahani, RL; Kirby, KA; Du, HJ; Hachiya, A; Zhang, HC; Tedbury, PR; Xie, JS; Sarafianos, SG; Wang, ZQ or send Email.. SDS of cas: 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors El Rayes, SM; Ali, IAI; Fathalla, W; Mahmoud, MAA in AMER CHEMICAL SOC published article about PHARMACOLOGICAL EVALUATION; LIGANDS; GROWTH in [El Rayes, Samir M.; Ali, Ibrahim A. I.; Mahmoud, Mostafa A. A.] Suez Canal Univ, Fac Sci, Dept Chem, Ismailia 41529, Egypt; [Fathalla, Walid] Port Said Univ, Fac Engn, Phys & Math Engn Dept, Port Said 42526, Egypt in 2020, Cited 24. Name: Benzo[d][1,2,3]triazin-4(3H)-one. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4

In one-pot strategy, diazotization of methyl anthranilate 5 followed by addition of amino acid ester hydrochloride, we have prepared methyl-2-(4-oxobenzotriazin-3(4H)-yl)-alkanoates 6a-c. Starting with hydrazides 7a,b, N-alkyl-2-(4-oxobenzotriazin-3(4H)-yl)-alkanamides 9-10(a-h) and methyl-2-(2-(4-oxobenzotriazin-3(4H)-yl)alkanamido)alkanoates 11- 12(a-e) were prepared via azide coupling. Hydrazones 13-15 were prepared via condensation of hydrazides 7a,b with 4-methoxybenzaldehyde, 4-dimethylaminobenzaldehyde, and/or arabinose. Molecular docking was done for synthesized compounds using MOE 2008-10 software. The compounds 9a, 12a, 12c, 13a, 13b, and 14b have the most pronounced strong binding affinities toward the target E. coli Fab-H receptor, whereas compounds 3, 11e, 12e, and 13a have the most pronounced strong binding affinities toward the target vitamin D receptor. The in vitro antibacterial activities of the highest binding affinity docked compounds were tested against E. coli, Staphylococcus aureus, and Salmonella spp. Majority of the tested compounds showed effective positive results against E. coli, while they were almost inactive against Staphylococcus aureus and Salmonella spp. The in vitro cytotoxic activities of the highest binding affinity-docked compounds were tested against the human liver carcinoma cell line (HepG2). Some compounds showed potent cytotoxic activity with low IC50 values, especially for 3 (6.525 mu M) and 13a (10.97 mu M) than that for standard drug doxorubicin (2.06 mu M).

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Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Authors Gurney, ME; Nugent, RA; Mo, XS; Sindac, JA; Hagen, TJ; Fox, D; O’Donnell, JM; Zhang, C; Xu, Y; Zhang, HT; Groppi, VE; Bailie, M; White, RE; Romero, DL; Vellekoop, AS; Walker, JR; Surman, MD; Zhu, L; Campbell, RF in AMER CHEMICAL SOC published article about CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; CAMP-SPECIFIC PHOSPHODIESTERASE; LONG-TERM-MEMORY; PROTEIN-KINASE; MOLECULAR-MECHANISMS; ADENYLYL-CYCLASE; STRUCTURAL BASIS; AMP PRODUCTION; KNOCKOUT MICE; DROSOPHILA in [Gurney, Mark E.; Nugent, Richard A.; Mo, Xuesheng; Sindac, Janice A.] Tetra Discovery Partners Inc, 38 Fulton St West, Grand Rapids, MI 49503 USA; [Hagen, Timothy J.] Northern Illinois Univ, Dept Chem & Biochem, 1425 West Lincoln Highway, De Kalb, IL 60115 USA; [Fox, David, III] Beryllium Discovery Corp, 7869 NE Day Rd West, Bainbridge Isl, WA 98110 USA; [O’Donnell, James M.; Zhang, Chong; Xu, Ying] SUNY Buffalo, Dept Pharmaceut Sci, Sch Pharm & Pharmaceut Sci, Buffalo, NY 14214 USA; [Zhang, Han-Ting] West Virginia Univ, Hlth Sci Ctr, Rockefeller Neurosci Inst, Dept Behav Med & Psychiat, 1 Med Ctr Dr, Morgantown, WV 26506 USA; [Zhang, Han-Ting] West Virginia Univ, Hlth Sci Ctr, Rockefeller Neurosci Inst, Dept Physiol Pharmacol & Neurosci, 1 Med Ctr Dr, Morgantown, WV 26506 USA; [Groppi, Vincent E.] Univ Michigan, Michigan Drug Discovery, Life Sci Inst, 210 Washtenaw Ave, Ann Arbor, MI 48103 USA; [Bailie, Marc] INDS Inc, 6111 Jackson Rd,Suite 100, Ann Arbor, MI 48103 USA; [White, Ronald E.] White Global Pharma Consultants, 31 Kinglet Dr, South Cranbury, NJ 08512 USA; [Romero, Donna L.] Pharma Vat Consulting LLC, 1201 Turnberry Ridge Court, Chesterfield, MO 63005 USA; [Vellekoop, A. Samuel; Walker, Joel R.; Surman, Matthew D.; Zhu, Lei; Campbell, Robert F.] Albany Mol Res Inc, 21 Corp Circle, Albany, NY 12203 USA; [Fox, David, III] UCB Pharma, 7869 NE Day Rd West, Bainbridge Isl, WA 98110 USA; [Zhang, Chong] Janssen China R&D, 65 Guiqing Rd,Bldg A,Floor 6, Shanghai 200233, Peoples R China; [Campbell, Robert F.] Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA in 2019.0, Cited 81.0. Category: amides-buliding-blocks. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

Novel pyridine- and pyrimidine-based allosteric inhibitors are reported that achieve PDE4D subtype selectivity through recognition of a single amino acid difference on a key regulatory domain, known as UCR2, that opens and closes over the catalytic site for cAMP hydrolysis. The design and optimization of lead compounds was based on iterative analysis of X-ray crystal structures combined with metabolite identification. Selectivity for the activated, dimeric form of PDE4D provided potent memory enhancing effects in a mouse model of novel object recognition with improved tolerability and reduced vascular toxicity over earlier PDE4 inhibitors that lack subtype selectivity. The lead compound, 28 (BPN14770), has entered midstage, human phase 2 clinical trials for the treatment of Fragile X Syndrome.

Welcome to talk about 104-10-9, If you have any questions, you can contact Gurney, ME; Nugent, RA; Mo, XS; Sindac, JA; Hagen, TJ; Fox, D; O’Donnell, JM; Zhang, C; Xu, Y; Zhang, HT; Groppi, VE; Bailie, M; White, RE; Romero, DL; Vellekoop, AS; Walker, JR; Surman, MD; Zhu, L; Campbell, RF or send Email.. Category: amides-buliding-blocks

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Dynamic Control of Chiral Space Through Local Symmetry Breaking in a Rotaxane Organocatalyst published in 2019.0. Formula: C13H13N, Reprint Addresses Leigh, DA (corresponding author), Univ Manchester, Sch Chem, Oxford Rd, Manchester M13 9PL, Lancs, England.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

We report on a switchable rotaxane molecular shuttle that features a pseudo-meso 2,5-disubstituted pyrrolidine catalytic unit on the axle whose local symmetry is broken according to the position of a threaded benzylic amide macrocycle. The macrocycle can be selectively switched (with light in one direction; with catalytic acid in the other) with high fidelity between binding sites located to either side of the pyrrolidine unit. The position of the macrocycle dictates the facial bias of the rotaxane-catalyzed conjugate addition of aldehydes to vinyl sulfones. The pseudo-meso non-interlocked thread does not afford significant selectivity as a catalyst (2-14 % ee), whereas the rotaxane affords selectivities of up to 40 % ee with switching of the position of the macrocycle changing the handedness of the product formed (up to 60 % Delta ee).

Formula: C13H13N. Welcome to talk about 91-00-9, If you have any questions, you can contact Dommaschk, M; Echavarren, J; Leigh, DA; Marcos, V; Singleton, TA or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Name: Diphenylmethanamine. In 2019.0 ASIAN J ORG CHEM published article about CATALYZED TRANSAMIDATION; EFFICIENT CATALYST; CARBOXYLIC-ACIDS; SECONDARY AMIDES; CARBOXAMIDES; AMINES; SOLVENT; UREAS; COMPLEX in [Yu, Subeen; Lee, Sunwoo] Chonnam Natl Univ, Dept Chem, Gwangju 61186, South Korea; [Song, Kwang Ho] Korea Univ, Dept Chem & Biol Engn, Seoul 02841, South Korea in 2019.0, Cited 66.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A metal-free transamidation of primary amides was developed. Trimethylsilyl chloride (TMSCl) acted as the activator in transamidation. In the presence of TMSCl, primary amides reacted with primary amines to yield transamidated secondary amides in NMP solvent. The transamidation of benzamide with secondary amines for the formation of tertiary amides succeeds in an NMP/CHCl3 solvent mixture.

Name: Diphenylmethanamine. Welcome to talk about 91-00-9, If you have any questions, you can contact Yu, S; Song, KH; Lee, S or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Computed Properties of C13H13N. Authors Chen, DH; Sun, WT; Zhu, CJ; Lu, GS; Wu, DP; Wang, AE; Huang, PQ in WILEY-V C H VERLAG GMBH published article about in [Chen, Dong-Huang; Sun, Wei-Ting; Zhu, Cheng-Jie; Lu, Guang-Sheng; Wu, Dong-Ping; Wang, Ai-E; Huang, Pei-Qiang] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China; [Chen, Dong-Huang; Sun, Wei-Ting; Zhu, Cheng-Jie; Lu, Guang-Sheng; Wu, Dong-Ping; Wang, Ai-E; Huang, Pei-Qiang] Xiamen Univ, Fujian Prov Key Lab Chem Biol, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China; [Wang, Ai-E; Huang, Pei-Qiang] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China in 2021.0, Cited 89.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

The combination of transition-metal catalysis and organocatalysis increasingly offers chemists opportunities to realize diverse unprecedented chemical transformations. By combining iridium with chiral thiourea catalysis, direct enantioselective reductive cyanation and phosphonylation of secondary amides have been accomplished for the first time for the synthesis of enantioenriched chiral alpha-aminonitriles and alpha-aminophosphonates. The protocol is highly efficient and enantioselective, providing a novel route to the synthesis of optically active alpha-functionalized amines from the simple, readily available feedstocks. In addition, the reactions are scalable and the thiourea catalyst can be recycled and reused.

Computed Properties of C13H13N. Welcome to talk about 91-00-9, If you have any questions, you can contact Chen, DH; Sun, WT; Zhu, CJ; Lu, GS; Wu, DP; Wang, AE; Huang, PQ or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2020 BIOORG MED CHEM LETT published article about SYSTEMIC ACQUIRED-RESISTANCE; ROTYLENCHULUS-RENIFORMIS; ELICITORS; NEMATICIDES; EFFICACY; TOMATO; PLANTS; SPP. in [Zhang, Ruifeng; Wang, Gaolei; Chen, Xiulei; Li, Zhong; Xu, Xiaoyong] East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China; [Guo, Wei] China Crop Protect Ind Assoc, Beijing 100723, Peoples R China in 2020, Cited 28. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4. Product Details of 90-16-4

Based on the characteristic of benzo[d][1,2,3]thiadiazole to induce the systemic acquired resistance and improve the immunity of plants, benzo[d][1,2,3]thiadiazole was introduced into 1,2,3-benzotriazin-4-one, thirty-one novel 1,2,3-benzotriazin-4-one derivatives containing benzo[d][1,2,3]thiadiazole were designed and synthesized. Nematicidal activity showed that most of the synthesized compounds exhibited great inhibitory activity in vivo against Meloidogyne incognita at 20 mg/L. Among 31 tested compounds, A2 and A3 showed an excellent nematicidal activity with the inhibition rate of 50.4% and 53.1% at the concentration of 1.0 mg/L, respectively. The influence of substituent type and position was investigated. The relationship between structure and activity was also preliminary analyzed.

Bye, fridends, I hope you can learn more about C7H5N3O, If you have any questions, you can browse other blog as well. See you lster.. Product Details of 90-16-4

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics