Month: November 2021

An article Pd-catalyzed stereoselective tandem ring-opening amination/cyclization of vinyl gamma-lactones: access to caprolactam diversity WOS:000562597500014 published article about ENANTIOSELECTIVE SYNTHESIS; HIGHLY EFFICIENT; LACTAM SYNTHESIS; AMIDES; ACIDS; POLYMERIZATION; HYDROGENATION; HETEROCYCLES; SUBSTITUTION; CAPURAMYCIN in [Xie, Jianing; Li, Xuetong; Kleij, Arjan W.] Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ, Av Paisos Catalans 16, Tarragona 43007, Spain; [Kleij, Arjan W.] Catalan Inst Res & Adv Studies ICREA, Pg Lluis Co 23, Barcelona 08010, Spain in 2020.0, Cited 68.0. Quality Control of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A stereoselective amination/cyclization cascade process has been developed that allows for the preparation of a series of unsaturated and substituted caprolactam derivatives in good yields. This conceptually novel protocol takes advantage of the easy access and modular character of vinyl gamma-lactones that can be prepared from simple precursors. Activation of the lactone substrate in the presence of a suitable Pd precursor and newly developed phosphoramidite ligand offers a stereocontrolled ring-opening/allylic amination manifold under ambient conditions. The intermediate (E)-configured epsilon-amino acid can be cyclized using a suitable dehydrating agent in an efficient one-pot, two-step sequence. This overall highly chemo-, stereo- and regio-selective transformation streamlines the production of a wide variety of modifiable and valuable caprolactam building blocks in an operationally attractive way.

Welcome to talk about 91-00-9, If you have any questions, you can contact Xie, JN; Li, XT; Kleij, AW or send Email.. Quality Control of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about SULFOXONIUM YLIDES; BOND ACTIVATION; RH(III)-CATALYZED SYNTHESIS; ORGANIC-SYNTHESIS; DIAZO-COMPOUNDS; PRIMARY AMINES; BENZYLAMINES; ANNULATION; ALKYNES; FUNCTIONALIZATION, Saw an article supported by the NSFCNational Natural Science Foundation of China (NSFC) [81373259, 81573286, 81602954]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Nie, RF; Lai, RZ; Lv, SY; Xu, YY; Guo, L; Wang, QT; Wu, Y. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. Formula: C13H13N

A water-mediated C-H activation using sulfoxonium ylides is reported, providing a general, green and step-economic approach to construct a C-C bond and varieties of useful N-heterocycle scaffolds. Notably, the water-mediated activation, in contrast to that in organic solvents, shows great potential in pharmaceutical, biochemistry and chemical industries.

Welcome to talk about 91-00-9, If you have any questions, you can contact Nie, RF; Lai, RZ; Lv, SY; Xu, YY; Guo, L; Wang, QT; Wu, Y or send Email.. Formula: C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Ozenil, M; Pacher, K; Balber, T; Vraka, C; Roller, A; Holzer, W; Spreitzer, H; Mitterhauser, M; Wadsak, W; Hacker, M; Pichler, V in [Ozenil, Marius; Pacher, Katharina; Balber, Theresa; Vraka, Chrysoula; Mitterhauser, Markus; Wadsak, Wolfgang; Hacker, Marcus; Pichler, Verena] Med Univ Vienna, Dept Biomed Imaging & Image Guided Therapy, Div Nucl Med, Vienna, Austria; [Balber, Theresa; Mitterhauser, Markus] Ludwig Boltzmann Inst Appl Diagnost, Vienna, Austria; [Roller, Alexander] Univ Vienna, Fac Chem, Xray Struct Anal Ctr, Vienna, Austria; [Holzer, Wolfgang; Spreitzer, Helmut] Univ Vienna, Fac Life Sci, Dept Pharmaceut Chem, Vienna, Austria; [Wadsak, Wolfgang] CBmed GmbH, Ctr Biomarker Res Med, Graz, Austria published Enhanced arecoline derivatives as muscarinic acetylcholine receptor M1 ligands for potential application as PET radiotracers in 2020.0, Cited 50.0. Safety of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Supported by their involvement in many neurodegenerative disorders, muscarinic acetylcholine receptors ( mAChRs) are an interesting target for PET imaging. Nevertheless, no radiotracer is established in clinical routine. Within this work we aim to develop novel PET tracers based on the structure of arecoline. Fifteen novel arecoline derivatives were synthesized, characterized and tested for their affinity to the mAChRs M1-M5 and the conceivable off-target acetylcholinesterase. Five arecoline derivatives and arecoline were labeled with carbon-11 in good yields. Arecaidine diphenylmethyl ester (3b), arecaidine bis(4-fluorophenyl)methyl ester (3c) and arecaidine (4-bromophenyl)(4-fluorophenyl)methyl ester (3e) showed a tremendous gain in mAChR affinity compared to arecoline and a pronounced subtype selectivity for M1. Metabolic stability and serum protein binding of [C-11] 3b and [C-11] 3c were in line with properties of established brain tracers. Nonspecific binding of [C-11]3c was prevalent in kinetic and endpoint experiment on living cells as well as in autoradiography on native mouse brain sections, which motivates us to decrease the lipophilicity of this substance class prior to in vivo experiments. (C) 2020 The Author(s). Published by Elsevier Masson SAS.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Hatano, M; Nishio, K; Mochizuki, T; Nishikawa, K; Ishihara, K in AMER CHEMICAL SOC published article about TRIMETHYLSILYL CYANIDE; ENANTIOSELECTIVE CYANOSILYLATION; PRACTICAL SYNTHESIS; AMINO-ACIDS; CYANATION; IMINES; PENTACOORDINATE; HYDROCYANATION; REACTIVITY; ALDIMINES in [Hatano, Manabu; Nishio, Kosuke; Mochizuki, Takuya; Nishikawa, Keisuke; Ishihara, Kazuaki] Nagoya Univ, Grad Sch Engn, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648603, Japan in 2019.0, Cited 84.0. Recommanded Product: 91-00-9. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

An enantioselective Strecker-type reaction of aldimines and ketimines was developed by using a chiral dilithium(I) binaphthyldisulfonate as a chiral acid-base cooperative catalyst. The present catalytic system features an extremely short reaction time (10 min to 4 h), unlike conventional catalytic systems. Along with the design of stronger chiral Li(I) Lewis acid catalysts, a highly reactive pentacoordinate silicate generated in situ could promote the reactions. In particular, instead of unstable N-Bn Strecker products, more stable N-CH2 (9-anthryl) and N-CH2 (1-naphthyl) Strecker products could be obtained in high yields with high enantioselectivities. By a switch of the present and previous catalyst systems, chemoselective cyanation to a ketoaldimine could be performed, respectively. Moreover, mechanistic investigations provided useful information regarding the active catalysts, catalytic cycles, and possible transition states.

Welcome to talk about 91-00-9, If you have any questions, you can contact Hatano, M; Nishio, K; Mochizuki, T; Nishikawa, K; Ishihara, K or send Email.. Recommanded Product: 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Reddy, GS; Snehalatha, AV; Edwin, RK; Hossain, KA; Giliyaru, VB; Hariharapura, RC; Shenoy, GG; Misra, P; Pal, M in [Reddy, Gangireddy Sujeevan; Snehalatha, Ampalam Venkata; Edwin, Rebecca Kristina; Hossain, Kazi Amirul; Misra, Parimal; Pal, Manojit] Dr Reddys Inst Life Sci, Univ Hyderabad Campus, Hyderabad 500046, India; [Reddy, Gangireddy Sujeevan; Giliyaru, Varadaraj Bhat; Hariharapura, Raghu Chandrashekhar; Shenoy, G. Gautham] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal 576104, Karnataka, India published Synthesis of 3-indolylmethyl substituted (pyrazolo/benzo)triazinone derivatives under Pd/Cu-catalysis: Identification of potent inhibitors of chorismate mutase (CM) in 2019, Cited 38. Safety of Benzo[d][1,2,3]triazin-4(3H)-one. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4.

The chorismate mutase (CM) is considered as an attractive target for the identification of potential antitubercular agents due to its absence in animals but not in bacteria. A series of 3-indolylmethyl substituted pyrazolo-triazinone derivatives were designed and docked into CM in silico as potential inhibitors. These compounds were efficiently synthesized using the Pd/Cu-catalyzed coupling-cyclization in a single pot involving the construction of indole ring. The methodology was later extended to the preparation of corresponding benzo analogs of pyrazolotriazinones i.e. 3-indolylmethyl substituted benzotriazinone derivatives. Several of these novel compounds showed significant inhibition of CM when tested in vitro at 30 mu M. The SAR (Structure-Activity-Relationship) studies suggested that benzotriazinone moiety was more favorable over the pyrazolotriazinone ring. The two best active compounds showed IC50 similar to 0.4-0.9 mu M (better than the reference/known compounds used) and no toxicity till 30 mu M in vitro.

Safety of Benzo[d][1,2,3]triazin-4(3H)-one. Welcome to talk about 90-16-4, If you have any questions, you can contact Reddy, GS; Snehalatha, AV; Edwin, RK; Hossain, KA; Giliyaru, VB; Hariharapura, RC; Shenoy, GG; Misra, P; Pal, M or send Email.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recently I am researching about MEINWALD REARRANGEMENT REACTIONS; PROMOTED REARRANGEMENT; SELECTIVE SYNTHESIS; CONVERSION; CYCLOPROPANES; CARBONYLATION; COMPLEXES; OXIDATION; ALDEHYDES, Saw an article supported by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO) through the Centres of Excellence Severo Ochoa award [CTQ2017-87840-P, CTQ2017-87889-P]; IRB Barcelona through the CERCA Programme of the Catalan Government; MINECO; UAB. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Cabre, A; Cabezas-Gimenez, J; Sciortino, G; Ujaque, G; Verdaguer, X; Lledos, A; Riera, A. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. Recommanded Product: Diphenylmethanamine

The isomerization of epoxides to aldehydes using the readily available Crabtree’s reagent is described. The aldehydes were transformed into synthetically useful amines by a one-pot reductive amination using pyrrolidine as imine-formation catalyst. The reactions worked with low catalyst loadings in very mild conditions. The procedure is operationally simple and tolerates a wide range of functional groups. A DFT study of its mechanism is presented showing that the isomerization takes place via an iridium hydride mechanism with a low energy barrier, in agreement with the mild reaction conditions.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Rh(III)-Catalyzed Coupling of N-Chloroimines with alpha-Diazo-alpha-phosphonoacetates for the Synthesis of 2H-Isoindoles published in 2019.0. Name: Diphenylmethanamine, Reprint Addresses Zhu, J (corresponding author), Nanjing Univ, Collaborat Innovat Ctr Chem Life Sci, Nanjing Natl Lab Microstruct, Dept Polymer Sci & Engn,Sch Chem & Chem Engn,Stat, Nanjing 210093, Jiangsu, Peoples R China.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

We report herein the first use of N-chloroimines as effective synthons for directed C-H functionalization. Rh(III)-catalyzed coupling of N-chloroimines with alpha-diazo-alpha-phosphonoacetates allows for efficient dechlorinative/dephosphonative access to 2H-isoindoles. Further deesterification under Ni(II) catalysis enables the complete elimination of reactivity-assisting groups and full exposure of reactivity of C3 and N2 ring atoms for attaching structurally distinct appendages.

Name: Diphenylmethanamine. Welcome to talk about 91-00-9, If you have any questions, you can contact Qi, B; Li, L; Wang, Q; Zhang, WJ; Fang, LL; Zhu, J or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocks. Yum, JH; Sugiyama, H; Park, S in [Yum, Ji Hye; Sugiyama, Hiroshi; Park, Soyoung] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kitashirakawa Oiwakecho, Kyoto 6068502, Japan; [Sugiyama, Hiroshi] Kyoto Univ, Inst Integrated Cell Mat Sci iCeMS, Sakyo Ku, Yoshida Ushinomiyacho, Kyoto 6068501, Japan published Modular quadruplex-duplex hybrids as biomolecular scaffolds for asymmetric Michael addition reactions in 2020.0, Cited 45.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9.

Asymmetric synthesis based on DNA scaffolds has been actively exploited because of the advantages of DNA such as diverse tertiary structures, chemical stability, and easy handling. Since duplex DNA-based hybrid catalysts have demonstrated this remarkable capability, efforts have been made to investigate new biomolecular scaffolds. Herein, we report modular quadruplex-duplex (QD) hybrid DNA catalysts containing bipyridine ligands and hydrogen donor moieties. The conformation, thermal stability, and metal-binding ability of modified QD hybrid DNA were characterized using spectroscopy. The QD hybrid-based DNA catalysts were successfully applied to asymmetric Michael addition reactions (86% conversion and 76% ee). This study describes a new type of DNA hybrid catalyst produced by the construction of a cooperative active site with a Lewis acid and a H-bond donor.

Category: amides-buliding-blocks. Welcome to talk about 104-10-9, If you have any questions, you can contact Yum, JH; Sugiyama, H; Park, S or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2020.0 APPL ORGANOMET CHEM published article about CRYSTAL-STRUCTURE; ALKYLATION; ALCOHOLS; AMINATION; DEHYDROGENATION; SECONDARY; KETONES; IMINES; 5-(2-PYRIDYLMETHYLENE)HYDANTOIN; HYDROAMINATION in [Ruiz-Castaneda, Margarita; Rodriguez, Ana M.; Manzano, Blanca R.; Jalon, Felix A.] Univ Castilla La Mancha, Fac Quim, Dept Quim Inorgan Organ & Bioquim, IRICA, Avda Camilo J Cela 10, Ciudad Real 13071, Spain; [Aboo, Ahmed H.; Xiao, Jianliang] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England; [Espino, Gustavo] Univ Burgos, Fac Ciencias, Dept Quim, Plaza Misael Banuelos S-N, Burgos 09001, Spain in 2020.0, Cited 70.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Category: amides-buliding-blocks

The development of efficient and eco-friendly methods for the synthesis of elaborate amines is highly desired as they are valuable chemicals. The catalytic alkylation of amines using alcohols as alkylating agents, through the so-called borrowing hydrogen process, satisfies several of the principles of green chemistry. In this paper, four neutral half-sandwich complexes of Ru(II), Rh(III), and Ir(III) have been synthesized and tested as catalysts in theN-benzylation of amines with benzyl alcohol. The new derivatives contain aN(boolean AND)N ‘ anionic ligand derived from 5-(pyridin-2-ylmethylene)hydantoin (Hpyhy) that has never been tested in metal complexes with catalytic applications. In particular, the Ir derivatives, [(Cp*)IrX(pyhy)] (X = Cl or H), exhibit high activity along with good selectivity in the process. Indeed, the scope of the optimized protocol has been proved in the benzylation of several primary and secondary amines. The selectivity towards monoalkylated or dialkylated amines has been tuned by adjusting the amine:alcohol ratio and the reaction time. Experimental results support a mechanism consisting of three consecutive steps, two of which are Ir catalyzed, and a favorable condensation step without the assistance of the catalyst. Moreover, an unproductive competitive pathway can operate when the reaction is performed in open-air vessels, due to the irreversible release of H-2. This route is hampered when the reaction is carried out in close vessels, likely because the release of H(2)is reversed through metal-based heterolytic cleavage. From our viewpoint, these results show the potential of the new catalysts in a very attractive and promising methodology for the synthesis of amines.

Category: amides-buliding-blocks. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Chen, DH; Sun, WT; Zhu, CJ; Lu, GS; Wu, DP; Wang, AE; Huang, PQ in WILEY-V C H VERLAG GMBH published article about in [Chen, Dong-Huang; Sun, Wei-Ting; Zhu, Cheng-Jie; Lu, Guang-Sheng; Wu, Dong-Ping; Wang, Ai-E; Huang, Pei-Qiang] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China; [Chen, Dong-Huang; Sun, Wei-Ting; Zhu, Cheng-Jie; Lu, Guang-Sheng; Wu, Dong-Ping; Wang, Ai-E; Huang, Pei-Qiang] Xiamen Univ, Fujian Prov Key Lab Chem Biol, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China; [Wang, Ai-E; Huang, Pei-Qiang] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China in 2021.0, Cited 89.0. Quality Control of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

The combination of transition-metal catalysis and organocatalysis increasingly offers chemists opportunities to realize diverse unprecedented chemical transformations. By combining iridium with chiral thiourea catalysis, direct enantioselective reductive cyanation and phosphonylation of secondary amides have been accomplished for the first time for the synthesis of enantioenriched chiral alpha-aminonitriles and alpha-aminophosphonates. The protocol is highly efficient and enantioselective, providing a novel route to the synthesis of optically active alpha-functionalized amines from the simple, readily available feedstocks. In addition, the reactions are scalable and the thiourea catalyst can be recycled and reused.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics