Recently I am researching about BINDING; MECHANISMS; INSIGHTS; ACID, Saw an article supported by the University of Chieti G. d’Annunzio local grants; grant Combattere la resistenza tumorale: piattaforma integrata multidisciplinare per un approccio tecnologico innovativo alle oncoterapie – CAMPANIA ONCOTERAPIE of Regione Campania (Italy). Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Giampietro, L; Laghezza, A; Cerchia, C; Florio, R; Recinella, L; Capone, F; Ammazzalorso, A; Bruno, I; De Filippis, B; Fantacuzzi, M; Ferrante, C; Maccallini, C; Tortorella, P; Verginelli, F; Brunetti, L; Cama, A; Amoroso, R; Loiodice, F; Lavecchia, A. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol. Computed Properties of C8H11NO
The development of PPAR alpha/gamma dual or PPAR alpha/gamma/S pan-agonists could represent an efficacious approach for a simultaneous pharmacological intervention on carbohydrate and lipid metabolism. Two series of new phenyldiazenyl fibrate derivatives of GL479, a previously reported PPAR alpha/gamma dual agonist, were synthesized and tested. Compound 12a was identified as a PPAR pan-agonist with moderate and balanced activity on the three PPAR isoforms (alpha, gamma, delta). Moreover, docking experiments showed that 12a adopts a different binding mode in PPARy compared to PPARa or PPARS, providing a structural basis for further structure-guided design of PPAR pan-agonists. The beneficial effects of 12a were evaluated both in vitro, on the expression of PPAR target key metabolic genes, and ex vivo in two rat tissue inflammatory models. The obtained results allow considering this compound as an interesting lead for the development of a new class of PPAR pan-agonists endowed with an activation profile exploitable for therapy of metabolic syndrome.
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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics