Month: December 2021

Recently I am researching about NEDD8-ACTIVATING ENZYME-INHIBITOR; PROTEIN NEDDYLATION; IDENTIFICATION; PATHWAY; DEGRADATION; DISCOVERY; APOPTOSIS; LIGASES, Saw an article supported by the Chinese Minister of Science and Technology grant [2016YFA0501800]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81872747, 21702061, 81625018, 81820108022]; Innovative Research Team of High-level Local Universities in Shanghai; National Special Fund for State Key Laboratory of Bioreactor Engineering [2060204]; National Key R&D Programof China [2017YFB0202600]; Innovation Program of Shanghai Municipal Education CommissionInnovation Program of Shanghai Municipal Education Commission [2019-01-07-00-10-E00056]; Program of Shanghai Academic/Technology Research Leader [18XD1403800]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Chen, X; Yang, X; Mao, F; Wei, JL; Xu, YX; Li, BL; Zhu, J; Ni, SS; Jia, LJ; Li, J. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. Name: Diphenylmethanamine

Ubiquitin-like protein neddylation is overactivated in various human cancers and correlates with disease progression, and targeting this pathway represents a valuable therapeutic strategy. Our previous work disclosed an antihypertensive agent, candesartan cilexetic (CDC), serves as a novel neddylation inhibitor for suppressing tumor growth by targeting Nedd8-activating enzyme (NAE). In this study, 42 benzimidazole derivatives were designed and synthesized based on lead compound CDC to improve the neddylation inhibition and anticancer efficacy. Optimal benzimidazole-derived 35 displayed superior neddylation inhibition in enzyme assay compared to CDC (IC50 = 5.51 mu M vs 16.43 mu M), along with promising target inhibitory activity and killing selectivity in cancer cell. The results of cellular mechanism research combined with tumor growth suppression in human lung cancer cell A549 in vivo, accompanied with docking model, revealed that 35 has the potential to be developed as a promising neddylation inhibitor for anticancer therapy. (C) 2020 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 91-00-9, If you have any questions, you can contact Chen, X; Yang, X; Mao, F; Wei, JL; Xu, YX; Li, BL; Zhu, J; Ni, SS; Jia, LJ; Li, J or send Email.. Name: Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about ONE-POT SYNTHESIS; FLUORESCENT-PROBES; SULFONYL; REARRANGEMENT; TACHYKININ; ALKYNES; ACCESS; FUNCTIONALIZATION; 1,2,3-TRIAZOLES; ANNULATION, Saw an article supported by the NSFCNational Natural Science Foundation of China (NSFC) [21871296, 21907111]; Guangdong Natural Science Funds for Distinguished Young Scholars [2017A030306017]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [19ykpy128]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Li, GF; Zhao, M; Xie, JQ; Yao, Y; Mou, LY; Zhang, XW; Guo, XM; Sun, WS; Wang, Z; Xu, JC; Xue, JZ; Hu, T; Zhang, M; Li, M; Hong, L. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol. Application In Synthesis of 2-(4-Aminophenyl)ethanol

Novel 10 pi-electron cyclic amidines with excellent fluorescence properties were synthesized by a general and efficient 6 pi-electrocyclic ring closure of ketenimine and imine starting from N-sulfonyl triazoles and arylamines. The photophysical properties of cyclic amidine fluorophores have been studied in detail and have shown good properties of a large Stokes shift, pH insensitivity, low cytotoxicity and higher photostability, which have great potential for biological imaging. Furthermore, this novel fluorophore was successfully applied to the localization of the NK-1 receptor in living systems.

Application In Synthesis of 2-(4-Aminophenyl)ethanol. Welcome to talk about 104-10-9, If you have any questions, you can contact Li, GF; Zhao, M; Xie, JQ; Yao, Y; Mou, LY; Zhang, XW; Guo, XM; Sun, WS; Wang, Z; Xu, JC; Xue, JZ; Hu, T; Zhang, M; Li, M; Hong, L or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2021 GREEN CHEM published article about ALKYNE INSERTION; LIGANDS; ACIDS; ANNULATION; 1,2,3-BENZOTRIAZIN-4(3H)-ONES in [Tang, Guo] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China; Xiamen Univ, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Fujian, Peoples R China in 2021, Cited 54. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4. Name: Benzo[d][1,2,3]triazin-4(3H)-one

Metal-free, visible-light-induced denitrogenative phosphorylation of 1,2,3-benzotriazinones was achieved. With the use of eosin Y as a photoredox catalyst, N,N-diisopropylethylamine as a base, CH3CN-H2O as a solvent and sunlight or a blue LED as a light source, a variety of aryl-phosphonates, aryl-phosphinates, and aryl-phosphine oxides were efficiently prepared. In addition, B(2)pin(2) instead of P-nucleophiles as a radical acceptor was also demonstrated. The key advantages of this newly developed method are the clean reaction profile, use of a low-cost organic-dye catalyst, energy efficiency, broad substrate scope, good to excellent yields and large-scale synthetic applicability. The gram-scale synthesised compounds could be isolated in pure form just upon extraction, followed by re-crystallisation; no tedious chromatographic purification was required.

Welcome to talk about 90-16-4, If you have any questions, you can contact Chen, FS; Hu, SS; Li, SP; Tang, G; Zhao, YF or send Email.. Name: Benzo[d][1,2,3]triazin-4(3H)-one

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocks. Authors Wu, JL; Liu, SH; Huang, JL; Cui, Y; Ma, PW; Wu, DC; Matyjaszewski, K in AMER CHEMICAL SOC published article about in [Wu, Jinlun; Liu, Shaohong; Huang, Junlong; Cui, Yin; Ma, Pengwei; Wu, Dingcai] Sun Yat Sen Univ, Sch Chem, Key Lab Polymer Composite & Funct Mat, Minist Educ, Guangzhou 510275, Peoples R China; [Matyjaszewski, Krzysztof] Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA in 2021.0, Cited 57.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

Porous polymers have attracted tremendous interest in lithium-sulfur batteries due to the combination of good physical confinement and chemical immobilization to suppress the polysulfide shuttle. Currently, the development of facile and effective methods for fabrication of porous polymers with hierarchical porous structures, strong polar species, and efficient charge-transfer pathways is significant yet challenging, which is crucial for high-performance sulfur cathodes. Herein, for the first time, we present the successful development of a novel class of advanced hierarchical porous polymer nanosheets (AHPPNs) based on a union of surface-initiated atom transfer radical polymerization and a cross-linking-induced coassembly strategy. Due to their well-defined nanoarchitectures, AHPPNs are capable of providing a commendable shuttle-suppressing shield for polysulfides via strong chemisorption, hierarchical porous structures for immobilizing sulfur and relieving volume change, and shortened pathways for ions and electrons. Benefiting from these synergistic effects, the lithium-sulfur batteries assembled with S@AHPPNs cathodes exhibit greatly enhanced rate performance and long stable cycle capability.

Bye, fridends, I hope you can learn more about C8H11NO, If you have any questions, you can browse other blog as well. See you lster.. Category: amides-buliding-blocks

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein WOS:000505633400021 published article about E3 UBIQUITIN LIGASE; 2 SH2 DOMAIN; SIGNAL TRANSDUCER; PEPTIDOMIMETIC INHIBITORS; SMALL MOLECULES; DESIGN; DEGRADATION; ACTIVATOR; OPTIMIZATION; VALIDATION in [Zhou, Haibin; Bai, Longchuan; Xu, Renqi; Zhao, Yujun; Chen, Jianyong; McEachern, Donna; Yang, Chao-Yie; Liu, Zhaomin; Wang, Mi; Liu, Liu; Yi, Han; Wang, Shaomeng] Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI 48109 USA; [Zhou, Haibin; Bai, Longchuan; Xu, Renqi; Zhao, Yujun; Chen, Jianyong; McEachern, Donna; Yang, Chao-Yie; Liu, Zhaomin; Wang, Mi; Liu, Liu; Yi, Han; Wang, Shaomeng] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA; [Wang, Shaomeng] Univ Michigan, Dept Pharmacol, Med Sch, Ann Arbor, MI 48109 USA; [Wang, Shaomeng] Univ Michigan, Coll Pharm, Med Chem, 428 Church St, Ann Arbor, MI 48109 USA; [Chinnaswamy, Krishnapriya; Meagher, Jennifer L.; Stuckey, Jeanne A.] Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA; [Wen, Bo; Dai, Lipeng; Kumar, Praveen; Sun, Duxin] Univ Michigan, Coll Pharm, Dept Pharmaceut Sci, 428 Church St, Ann Arbor, MI 48109 USA in 2019.0, Cited 43.0. Computed Properties of C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor and an attractive therapeutic target for cancer and other human diseases. Despite 20 years of persistent research efforts, targeting STAT3 has been very challenging. We report herein the structure-based discovery of potent small-molecule STAT3 degraders based upon the proteolysis targeting chimera (PROTAC) concept. We first designed SI-109 as a potent, small-molecule inhibitor of the STAT3 SH2 domain. Employing ligands for cereblon/cullin 4A E3 ligase and SI-109, we obtained a series of potent PROTAC STAT3 degraders, exemplified by SD-36. SD-36 induces rapid STAT3 degradation at low nanomolar concentrations in cells and fails to degrade other STAT proteins. SD-36 achieves nanomolar cell growth inhibitory activity in leukemia and lymphoma cell lines with high levels of phosphorylated STAT3. A single dose of SD-36 results in complete STAT3 protein degradation in xenograft tumor tissue and normal mouse tissues. SD-36 achieves complete and long-lasting tumor regression in the Molm-16 xenograft tumor model at well-tolerated dose-schedules. SD-36 is a potent, selective, and efficacious STAT3 degrader.

Computed Properties of C13H13N. Welcome to talk about 91-00-9, If you have any questions, you can contact Zhou, HB; Bai, LC; Xu, RQ; Zhao, YJ; Chen, JY; McEachern, D; Chinnaswamy, K; Wen, B; Dai, LP; Kumar, P; Yang, CY; Liu, ZM; Wang, M; Liu, L; Meagher, JL; Yi, H; Sun, DX; Stuckey, JA; Wang, SM or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Salamoun, JM; Garcia, CJ; Hargett, SR; Murray, JH; Chen, SY; Beretta, M; Alexopoulos, SJ; Shah, DP; Olzomer, EM; Tucker, SP; Hoehn, KL; Santos, WL in AMER CHEMICAL SOC published article about FATTY LIVER-DISEASE; DIET-INDUCED OBESITY; OXIDATIVE-PHOSPHORYLATION; METABOLIC-INHIBITORS; INSULIN-RESISTANCE; CANCER-CELLS; DINITROPHENOL; PROTON; MECHANISM; BIOENERGETICS in [Hargett, Stefan R.; Hoehn, Kyle L.] Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USA; [Hargett, Stefan R.; Hoehn, Kyle L.] Univ Virginia, Dept Med, Charlottesville, VA 22908 USA; [Chen, Sing-Young; Beretta, Martina; Alexopoulos, Stephanie J.; Shah, Divya P.; Olzomer, Ellen M.; Hoehn, Kyle L.] Univ New South Wales, Sch Biotechnol & Biomol Sci, Kensington, NSW 2033, Australia; [Salamoun, Joseph M.; Garcia, Christopher J.; Murray, Jacob H.; Santos, Webster L.] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA; [Salamoun, Joseph M.; Garcia, Christopher J.; Murray, Jacob H.; Santos, Webster L.] Virginia Tech, Virginia Tech Ctr Drug Discovery, Blacksburg, VA 24061 USA; [Tucker, Simon P.] Continuum Biosci Pty Ltd, Sydney, NSW 2035, Australia; [Tucker, Simon P.] Continuum Biosci Inc, Boston, MA 02116 USA in 2020.0, Cited 93.0. Name: 2-(4-Aminophenyl)ethanol. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

Small molecule mitochondrial uncouplers have recently garnered great interest for their potential in treating nonalcoholic steatohepatitis (NASH). In this study, we report the structure-activity relationship profiling of a 6-amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol core, which utilizes the hydroxy moiety as the proton transporter across the mitochondrial inner membrane. We demonstrate that a wide array of substituents is tolerated with this novel scaffold that increased cellular metabolic rates in vitro using changes in oxygen consumption rate as a readout. In particular, compound SHS4121705 (12i) displayed an EC50 of 4.3 mu M in L6 myoblast cells and excellent oral bioavailability and liver exposure in mice. In the STAM mouse model of NASH, administration of 12i at 25 mg kg(-1) day(-1) lowered liver triglyceride levels and improved liver markers such as alanine aminotransferase, NAFLD activity score, and fibrosis. Importantly, no changes in body temperature or food intake were observed. As potential treatment of NASH, mitochondrial uncouplers show promise for future development.

Name: 2-(4-Aminophenyl)ethanol. Welcome to talk about 104-10-9, If you have any questions, you can contact Salamoun, JM; Garcia, CJ; Hargett, SR; Murray, JH; Chen, SY; Beretta, M; Alexopoulos, SJ; Shah, DP; Olzomer, EM; Tucker, SP; Hoehn, KL; Santos, WL or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Evaluation of Synthesized Ester or Amide Coumarin Derivatives on Aromatase Inhibitory Activity published in 2020.0. Category: amides-buliding-blocks, Reprint Addresses Yamaguchi, Y; Nishizono, N (corresponding author), Hlth Sci Univ Hokkaido, Sch Pharmaceut Sci, Ishikari, Hokkaido 0610293, Japan.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Aromatase inhibitors are effective for the treatment of diseases such as breast cancer, which has led to an increase in their demand. However, only a limited number of aromatase inhibitor drugs are currently being marketed. In addition, considering the important aspect of drug resistance, the development of newer drug types is required. We have been developing inhibitors with backbone structures that differ from existing aromatase inhibitors. In this regard, we previously reported that diethylaminocoumarin dimers and thiazolyl coumarin derivatives possess strong aromatase inhibiting capabilities. In this study, we further examined the structure activity relationships of coumarin derivatives synthesized from thiazolyl coumarin derivatives and their aromatase inhibiting capabilities. Consequently, amide coumarin N-benzhydry1-7-(diethylamino)2-oxo-2H-chromene-3-carboxamide (IC50 values 4.5 mu M) is inhibitor of aromatase. This inhibitor was found to be comparable aromatase inhibitory activity to the 1st generation aromatase inhibitor aminoglutethimide (3.2 mu M). Substitution of the amide group on the amide coumarin derivative affects the aromatase inhibiting activity. Our findings suggest that the structure of each substituent changes the orientation of the compound in the active site of aromatase, thus creating a difference in their activities.

Welcome to talk about 91-00-9, If you have any questions, you can contact Yamaguchi, Y; Nishizono, N; Oda, K or send Email.. Category: amides-buliding-blocks

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Synthesis and nematicidal evaluation of 1,2,3-benzotriazin-4-one derivatives containing piperazine as linker against Meloidogyne incognita WOS:000474501100016 published article about BIOLOGICAL-ACTIVITIES; MANNICH-BASES; DESIGN; ANTIFUNGAL; FLUORINE; PRODUCT; ANALOGS in [Chen, Xiulei; Jia, Haowu; Li, Zhong; Xu, Xiaoyong] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China; [Li, Zhong; Xu, Xiaoyong] Shanghai Collaborat Innovat Ctr Biomfg Technol, Shanghai 200237, Peoples R China in 2019, Cited 24. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4. Product Details of 90-16-4

To explore new skeleton with nematicidal activity, a series of novel 1,2,3-benzotriazin-4-one derivatives containing piperazine as linker were synthesized and varied fragments were also introduced to increase structure diversity of the new skeleton. Their inhibitory activities in vivo were evaluated against Meloidogyne incognita. The newly prepared compounds A6, A8, A21, A28 and A38 exhibited more than 50% inhibition at the concentration of 20 mg/L. Especially compound A6 displayed 71.4% inhibition against Meloidogyne incognita at the concentration of 20 mg/L. The nematicidal activities varied significantly depending on the types and positions of the substituents, which provided guidance for further structure modification. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Product Details of 90-16-4. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Chen, XL; Jia, HW; Li, Z; Xu, XY or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Authors Zhang, ZG; Dai, SW; Li, L; Jia, CY; Zhang, Y; Li, H in PERGAMON-ELSEVIER SCIENCE LTD published article about ALLYLIC SUBSTITUTION; FUNCTIONALIZATION; HYDROAMINATION; HETEROCYCLES; 2-PYRIDONES; ALKYLATION; DISCOVERY in [Zhang, Zhiguang; Dai, Siwei; Li, Ling; Jia, Chenyu; Zhang, Yong] Hebei Univ Sci & Technol, Coll Chem & Pharmaceut Engn, 26 Yuxiang Rd, Shijiazhuang 050018, Hebei, Peoples R China; [Li, Hao] East China Univ Sci & Technol, State Key Lab Bioengn Reactor, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China; [Li, Hao] East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China in 2020, Cited 35. Recommanded Product: Benzo[d][1,2,3]triazin-4(3H)-one. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4

We described a novel scandium-catalyzed selective Michael addition of quinazolinones and vinylazaarenes. The protocol proceeds smoothly to give diverse quinazolinone derivatives in moderate to excellent yields. The high practicality of this protocol was proved by excellent chemo selectivity and broad substrate and functional group compatibility. (C) 2020 Elsevier Ltd. All rights reserved.

Recommanded Product: Benzo[d][1,2,3]triazin-4(3H)-one. Bye, fridends, I hope you can learn more about C7H5N3O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: Benzo[d][1,2,3]triazin-4(3H)-one. In 2021 GREEN CHEM published article about ALKYNE INSERTION; LIGANDS; ACIDS; ANNULATION; 1,2,3-BENZOTRIAZIN-4(3H)-ONES in [Tang, Guo] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China; Xiamen Univ, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Fujian, Peoples R China in 2021, Cited 54. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4.

Metal-free, visible-light-induced denitrogenative phosphorylation of 1,2,3-benzotriazinones was achieved. With the use of eosin Y as a photoredox catalyst, N,N-diisopropylethylamine as a base, CH3CN-H2O as a solvent and sunlight or a blue LED as a light source, a variety of aryl-phosphonates, aryl-phosphinates, and aryl-phosphine oxides were efficiently prepared. In addition, B(2)pin(2) instead of P-nucleophiles as a radical acceptor was also demonstrated. The key advantages of this newly developed method are the clean reaction profile, use of a low-cost organic-dye catalyst, energy efficiency, broad substrate scope, good to excellent yields and large-scale synthetic applicability. The gram-scale synthesised compounds could be isolated in pure form just upon extraction, followed by re-crystallisation; no tedious chromatographic purification was required.

Recommanded Product: Benzo[d][1,2,3]triazin-4(3H)-one. Bye, fridends, I hope you can learn more about C7H5N3O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics