Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 84547-64-8, is researched, SMILESS is CN1N=C(CCl)C=C1, Molecular C5H7ClN2Journal, Chungnam Kwahak Yonguchi called Synthesis of new proton-pump inhibitors (2) and tests for it’s biological activity, Author is Kim, Hyo-Jeong; Kwon, Tae-Ik; Park, Il-Hyun, the main research direction is antiulcer agent omeprazole analog preparation.SDS of cas: 84547-64-8.
For development new anti-ulcer agents, we synthesized proton-pump (H+/K+-ATPase) inhibitors which inhibit gastric acid secretion at the last step in the parietal cell. These are omeprazole analogs, in which pyridine group is replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and we also synthesized substituted benzimidazole rings. The structure of the compounds was identified with 1H-NMR, M.S. and I.R. The compounds with 5-substituted benzimidazoles showed good activity in the following order MeO > Cl > H, and also, 1-benzyl group of pyrazole substituted compounds has enhanced activity.
As far as I know, this compound(84547-64-8)SDS of cas: 84547-64-8 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics