The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of new proton-pump inhibitors》. Authors are Kim, Hyo-Jeong; Park, Il-Hyun.The article about the compound:3-(Chloromethyl)-1-methyl-1H-pyrazolecas:84547-64-8,SMILESS:CN1N=C(CCl)C=C1).Application In Synthesis of 3-(Chloromethyl)-1-methyl-1H-pyrazole. Through the article, more information about this compound (cas:84547-64-8) is conveyed.
For development new anti-ulcer agents, we synthesized omeprazole analogs, in which pyridine group was replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and also synthesize substituted benzimidazole rings.
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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics